[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551086":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":55,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"NYU Langone Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Magnesium Sulfate","EXPERIMENTAL","Treatment of initial magnesium sulfate bolus followed by a continuous drip.",[13],"Drug: Magnesium Sulfate",{"label":15,"type":16,"description":17,"interventionNames":18},"Saline solution","PLACEBO_COMPARATOR","Treatment of equivalent volume of normal saline.",[19],"Drug: Saline",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","4 g of magnesium sulfate intravenously within 2 hours of Return of Spontaneous Circulation (ROSC), followed by a continuous drip (16 g) over 24 hours",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Saline","Control subjects will receive an equivalent volume of normal saline intravenously.",[15],[31],{"name":32,"affiliation":5,"role":33},"Sam Parnia","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Anelly Gonzales","CONTACT","646-501-6923","resuscitationlab@nyulangone.org",{"name":41,"role":37,"phone":38,"phoneExt":25,"email":39},"Natalia Leontovich",[43],{"facility":5,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"RECRUITING","New York","10016","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-74.00597,40.71427,{"lat":53,"lon":52},{"type":56,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[58],{"name":59,"class":60},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100551086","phase-1-post-ca-neuroprotection-with-magnesium-100551086",false,"NCT06455514","Post-CA Neuroprotection With Magnesium","Neuroprotection Following Cardiac Arrest: A Randomized Control Trial of Magnesium","Inclusion Criteria:\n\n* Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \\\u003C2 hours prior to recruitment\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 85 years\n* Traumatic cardiac arrests\n* Unsustained ROSC (\\\u003C20 minutes)\n* Patient who is responsive\u002Fable to follow motor commands within 1 hour of achieving ROSC\n* Plan for withdrawal of life support within 72 hours of ROSC\n* Known pregnant women at the time of the cardiac arrest\n* Known prisoners at the time of the cardiac arrest\n* Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.","ALL","18 Years","85 Years",{"count":72,"type":73},178,"ESTIMATED","INTERVENTIONAL",[76],"PHASE1","The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.",[79,80],"Cardiac Arrest","Return of Spontaneous Circulation","2026-04-01",{"date":83,"type":84},"2026-04-07","ACTUAL",{"date":86,"type":84},"2025-03-25",{"date":88,"type":73},"2026-06-30",{"name":5,"class":6},1]