[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628525":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Louisiana State University Health Sciences Center in New Orleans","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence A: Probiotic then Blueberry Extract","EXPERIMENTAL","Participants receive probiotic for 4 weeks, washout 6 weeks, then blueberry extract for 4 weeks.",[13,14],"Dietary Supplement: Limosilactobacillus reuteri","Dietary Supplement: Blueberry extract",{"label":16,"type":10,"description":17,"interventionNames":18},"Sequence B: Blueberry Extract then Probiotic","Participants receive blueberry extract for 4 weeks, washout 6 weeks, then probiotic for 4 weeks.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Limosilactobacillus reuteri","Administered as 6 capsules daily (3 twice daily) for 4 weeks. Each daily dose contains 1×10\\^10 CFU total in a 1:1 ratio of two strains. This is a GRAS dietary supplement and not an FDA-regulated investigational product.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Blueberry extract","Administered as 6 capsules daily (3 twice daily) for 4 weeks, providing 500 mg anthocyanins per day. This is a GRAS dietary supplement and not an FDA-regulated investigational product.",[9,16],[31],{"name":32,"affiliation":33,"role":34},"David A Welsh, MD","LSU Health New Orleans","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","United States","5045684634","dwelsh@lsuhsc.edu",[42],{"facility":43,"status":25,"city":44,"state":45,"zip":46,"country":38,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"LSU Health","New Orleans","Louisiana","70112","US",{"type":49,"coordinates":50},"Point",[51,52],-90.07507,29.95465,{"lat":52,"lon":51},[55],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},{"type":34,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"David Welsh","Professor","100628525","phase-1-precision-microbiota-interventions-for-senoreduction-trial-100628525",false,"NCT07462767","Precision Microbiota Interventions for Senoreduction Trial","Geroprotective Precision Medicine Strategies in PWH That Use Alcohol","PreMIS","Inclusion Criteria:\n\n* Age ≥40 years\n* People with HIV\n* Recent alcohol use defined as ≥42 grams in the prior week and positive urine ethyl glucuronide (EtG)\n\nExclusion Criteria:\n\n* Probiotic use in past 3 months\n* Recent antibiotics or immunosuppressives\n* Allergy to study products\n* Pregnancy or breastfeeding\n* Inability to comply","ALL","40 Years",{"count":70,"type":71},160,"ESTIMATED","INTERVENTIONAL",[74,75],"PHASE1","PHASE2","People with HIV who drink alcohol are at increased risk for accelerated aging biology, including increased immune senescence. This randomized, double-blind, crossover clinical trial evaluates two generally recognized as safe (GRAS) microbiota-targeted interventions on immune senescence biomarkers.",[78,79,80,81],"HIV Infections","Alcohol Drinking","Aging","Immunosenescence",[83,84,81,85,86,87,27,88],"People with HIV","Alcohol use","Senescence","Microbiome","Probiotic","Crossover trial","NOT_YET_RECRUITING","2026-03-05",{"date":92,"type":93},"2026-03-10","ACTUAL",{"date":95,"type":71},"2026-04-01",{"date":97,"type":71},"2029-12-01",{"name":5,"class":6},1]