[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586629":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":12,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":12,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":12,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":32,"whyStopped":12,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","NO_INTERVENTION","(Placebo group \u002F Control group) will receive normal saline as a placebo after the induction of anesthesia and before initiating CPB.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Methylprednisolone group","ACTIVE_COMPARATOR","(Methylprednisolone group ) receive a single intra-venous dose of methylprednisolone (2 mg\u002Fkg) after the induction of anesthesia, and before the initiation of CPB.",[18],"Drug: Methylprednisolone group",[20],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":12},"DRUG","In this study patients will be given a single intra-venous dose of methylprednisolone (2 mg\u002Fkg) after the induction of anesthesia, and before the initiation of CPB.",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Abdelrahman Atef Atef, M.B., B.Ch Faculty of Medicine","CONTACT","+201091541157","abdelrahman.atef@med.asu.edu.eg",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Cairo","Abbasia","00202","Egypt","EG",{"type":39,"coordinates":40},"Point",[41,42],31.24967,30.06263,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":47,"phoneExt":12,"email":29},"Abdelrahman Atef Dr.Abdelrahman, M.B., B.Ch Faculty of Medicine","01091541157",{"type":49,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100586629","phase-1-prophylactic-methylprednisolone-for-renal-protection-in-cardiac-surgeries-with-cardiopulmonary-bypass-100586629",false,"NCT06917859","Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass","Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass: A Randomized Double-Blinded Clinical Study","Inclusion Criteria:\n\n1. Age 18-65 years.\n2. Sex: Both sexes.\n3. Patients with American Society of Anesthesiologists (ASA) score III-IV.\n4. Patients scheduled for any kind of elective cardiac surgical procedure requiring cardiopulmonary bypass (e.g., coronary artery bypass grafting (CABG), valve repair\u002Freplacement, or combined procedures (\n\nExclusion Criteria:\n\n1. Declining to give written informed consent.\n2. History of allergy to the medications used in the study.\n3. Diabetic patients with HbA1C \\>6.5\n4. Moderate to severe hepatic diseases (Child B-C)\n5. Hepatic dysfunction: INR \\> 1.5, serum albumin \\\u003C 2.9 g%.\n6. Renal dysfunction (serum Creatinine level \\>1.3 mg\u002Fdl, or GFR \\\u003C 80 ml\u002Fmin.\u002F1.73\u002Fm2\n7. Patients with a recent history of AKI.\n8. Patients undergoing urgent cardiac surgery.\n9. Patients undergoing cardiac surgeries with deep hypothermic total circulatory arrest.\n10. Planned off-pump procedure.\n11. Any cardiac surgery exceeds 45 minutes on Aortic cross clamp.\n12. Patients requiring high doses of inotropes and\u002For vasopressors intraoperative or postoperative (high-dose dopamine is defined as peak doses of \\>15 μg\u002Fkg\u002Fmin, high-dose norepinephrine is defined as peak dose \\>0.1 μg\u002Fkg\u002Fmin, high-dose epinephrine is defined as peak dose \\>0.1 μg\u002Fkg\u002Fmin)\n13. Delayed extubation for more than 6 hours postoperative.\n14. Patients developed postoperative complications as (septic shock and bleeding)","ALL","18 Years","65 Years",{"count":61,"type":62},170,"ESTIMATED","INTERVENTIONAL",[65],"PHASE1","The aim of the planned study is to assess the prophylactic effect of intraoperative administration of a single dose of methylprednisolone 2 (mg\u002Fkg) in decreasing the incidence of postoperative acute kidney injury after cardiac surgeries with cardiopulmonary bypass.",[68,69],"Cardiopulmonary Bypass","AKI - Acute Kidney Injury",[71,72],"AKI","CPB","2025-04-04",{"date":75,"type":76},"2025-04-09","ACTUAL",{"date":78,"type":76},"2025-02-01",{"date":80,"type":62},"2026-12-01",{"name":5,"class":6},1]