[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524696":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":41,"centralContacts":45,"locations":50,"responsibleParty":67,"collaborators":40,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":40,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":40,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":53,"whyStopped":40,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"State University of New York - Upstate Medical University","OTHER",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate-dose rTMS","ACTIVE_COMPARATOR","12 sessions (1 session\u002Fday, 3 days\u002Fweek for 4 weeks) of active rTMS",[13],"Device: Repetitive Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS","SHAM_COMPARATOR","12 sessions (1 session\u002Fday, 3 days\u002Fweek for 4 weeks) of sham rTMS will be administered at the same location and duration as the Moderate-rTMS protocol. After the study is completed, participants will be offered an opportunity to receive active rTMS.",[19],"Device: Sham Repetitive Transcranial Magnetic Stimulation",{"label":21,"type":10,"description":22,"interventionNames":23},"High-dose rTMS","24 sessions (4 sessions\u002Fday, 3 days\u002Fweek for 2 weeks) of active rTMS",[13],{"label":25,"type":10,"description":26,"interventionNames":27},"Low-dose rTMS","6 sessions (1 session\u002Fday, 3 days\u002Fweek for 2 weeks) of active rTMS",[13],[29,36],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Repetitive Transcranial Magnetic Stimulation","rTMS will be used to regulate the motor cortex to reduce headaches and post-concussion symptoms.",[21,25,9],[35],"Transcranial magnetic stimulation",{"type":30,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Sham Repetitive Transcranial Magnetic Stimulation","Sham rTMS will be delivered by a sham coil as a comparator to the (active) rTMS. Sham rTMS will not change the brain function of the control group.",[15],null,[42],{"name":43,"affiliation":5,"role":44},"Yi-Ling Kuo, PT, PhD","PRINCIPAL_INVESTIGATOR",[46],{"name":43,"role":47,"phone":48,"phoneExt":40,"email":49},"CONTACT","3154646911","kuoy@upstate.edu",[51],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"SUNY Upstate Medical University","RECRUITING","Syracuse","New York","13210","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-76.14742,43.04812,{"lat":63,"lon":62},[66],{"name":43,"role":47,"phone":48,"phoneExt":40,"email":49},{"type":44,"investigatorFullName":43,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"Assistant Professor","100524696","phase-1-repetitive-transcranial-magnetic-stimulation-for-post-concussion-headaches-100524696",false,"NCT06112093","Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches","Using Repetitive Transcranial Magnetic Stimulation to Manage Headaches and Improve Rehabilitation Outcomes in Mild Traumatic Brain Injury: A Longitudinal Study","Inclusion Criteria:\n\n* 18 - 55 years old\n* mTBI with loss of consciousness for less than 30 min, initial Glasgow Coma Scale between 13 and 15, or post-traumatic amnesia for ≤ 24 hours\n* diagnosis of persistent post-traumatic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria\n* headache develops within 7 days after head trauma\n* headache persists for \\>=3 months after head trauma despite receiving standard care\n* average persistent headache intensity is \\>= 3\u002F10 of the numerical rating scale (NRS) on \\>=3days\u002Fweek\n* no evidence of radiculopathy or peripheral neuropathy on electromyography or clinical evaluation\n* no evidence of other possible causes of headaches\n\nExclusion Criteria:\n\n* history of chronic headache diagnoses such as migraine, tension, or cluster headaches prior to the incidence of mTBI\n* history of other neurologic conditions with medications affecting the central nervous system\n* contraindications of receiving TMS (e.g., a history of epileptic seizure and having implants like a cardiac pacemaker or intracerebral vascular clip",true,"ALL","18 Years","55 Years",{"count":81,"type":82},60,"ESTIMATED","INTERVENTIONAL",[85],"PHASE1","This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. This study uses rTMS to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. This project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mTBI.",[88,89,90,91],"Brain Concussion","Mild Traumatic Brain Injury","Headache","Post-Concussion Symptoms",[93,94,95,96,97],"Repetitive transcranial magnetic stimulation","Non-invasive brain stimulation","Neuromodulation","Chronic pain","Biomarkers","2025-10-08",{"date":100,"type":101},"2025-10-10","ACTUAL",{"date":103,"type":101},"2023-10-23",{"date":105,"type":82},"2027-10-23",{"name":5,"class":6},1]