[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609607":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":61,"collaborators":20,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":20,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":20,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Minicircle","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Schedule of Administration and Sample Selection","EXPERIMENTAL","This arm includes cognitive and health battery at multiple intervals pre- and post-administration of Klotho",[13],"Genetic: Injectable Plasmid Klotho Gene Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","Injectable Plasmid Klotho Gene Therapy","Injection of plasmid-delivered Klotho gene therapy",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Mac Davis","CONTACT","512-630-0882","mac@minicircle.io",[28,44],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Apeiron Center","RECRUITING","Austin","Texas","78701","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-97.74306,30.26715,{"lat":40,"lon":39},[43],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"facility":45,"status":46,"city":47,"state":48,"zip":20,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"GARM Clinic","NOT_YET_RECRUITING","Roatán","Bay Islands","Honduras","HN",{"type":37,"coordinates":52},[53,54],-86.53605,16.3229,{"lat":54,"lon":53},[57],{"name":58,"role":24,"phone":59,"phoneExt":20,"email":60},"Mayra Hoch","+504 2408-3544","mayra@garmclinic.com",{"type":62,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100609607","phase-1-safety-and-efficacy-of-injectable-klotho-plasmid-gene-therapy-in-humans-100609607",false,"NCT07216781","Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans","Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study","Inclusion Criteria:\n\n* Participant is open to morphological change\n* If female, participant agrees to maintain contraception\n* If female, participant agrees to take a pregnancy test\n* If female, participant agrees to a pregnancy waiver\n\nExclusion Criteria:\n\n* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study\n* History of cancer diagnosis\n* Preexisting medical issues that may be exacerbated by the treatment\n* Has received any gene therapy within the past 12 months\n* Unwilling or unable to provide written informed consent",true,"ALL","23 Years","90 Years",{"count":75,"type":76},24,"ESTIMATED","INTERVENTIONAL",[79],"PHASE1","The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.",[82],"Healthy Adults",[84,85,86],"Klotho","plasmid","gene therapy","2026-02-15",{"date":89,"type":90},"2026-02-17","ACTUAL",{"date":92,"type":90},"2025-10-06",{"date":94,"type":76},"2026-08",{"name":5,"class":6},2]