[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601502":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":26,"centralContacts":26,"locations":40,"responsibleParty":61,"collaborators":26,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":26,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Shanghai 6th People's Hospital","OTHER",[8,15,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"iEV-high","EXPERIMENTAL","1X10\\^10\u002Fml",[13,14],"Biological: iEV","Other: immobilization",{"label":16,"type":10,"description":17,"interventionNames":18},"iEV-Low","1X10\\^9\u002Fml",[13,14],{"label":20,"type":21,"description":20,"interventionNames":22},"PRP","ACTIVE_COMPARATOR",[23,14],"Biological: PRP",{"label":25,"type":6,"description":26,"interventionNames":27},"Control",null,[14],[29,34,37],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":26},"BIOLOGICAL","iEV","induced pluripotent stem cell-derived extracellular vesicles",[16,9],{"type":30,"name":20,"description":35,"armGroupLabels":36,"otherNames":26},"PRP injection",[20],{"type":6,"name":38,"description":38,"armGroupLabels":39,"otherNames":26},"immobilization",[25,20,16,9],[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Shanghai Sixth hospital","RECRUITING","Shanghai","Shanghai Municipality","200000","China","CN",{"type":50,"coordinates":51},"Point",[52,53],121.45806,31.22222,{"lat":53,"lon":52},[56],{"name":57,"role":58,"phone":59,"phoneExt":26,"email":60},"Jian Ding, Dr.","CONTACT","+86 021 64369181","liuyuanec@163.com",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Jian Ding","Doctor","100601502","phase-1-safety-and-preliminary-efficacy-of-ievs-injection-in-treating-lateral-epicondylitis-of-humerus-100601502",false,"NCT07111325","Safety and Preliminary Efficacy of iEVs Injection in Treating Lateral Epicondylitis of Humerus","A Clinical Trial Study Evaluating the Safety and Preliminary Efficacy of Human Induced Pluripotent Stem Cell-derived Extracellular Vesicles (iEVs) Injection for the Treatment of Lateral Epicondylitis of the Humerus","iEVs","Inclusion Criteria:\n\n* Diagnosed with lateral epicondylitis by clinical symptom examination and MRI or ultrasound, without obvious tendon tear;\n* Unilateral lateral elbow pain lasting for more than 12 weeks;\n* Pain is provoked by at least 2 of the following methods, with a pain VAS score exceeding 3: maximum grip strength, palpation of the lateral epicondyle of the elbow and surrounding area, resisted dorsiflexion of the wrist or middle finger, or stretching of the forearm extensor muscles under a pain-free grip state;\n* Having received physical therapy or non-steroidal anti-inflammatory drug treatment with poor efficacy;\n* Individuals with independent behavioral capacity, who have signed the informed consent form themselves.\n\nExclusion Criteria:\n\n* Complaints of ipsilateral muscle pain caused by other reasons in the past 6 months;\n* Presence of ipsilateral neurogenic, inflammatory, or systemic joint diseases;\n* A history of previous lateral epicondylitis (LET) surgery in the past 6 months;\n* Subjects deemed unsuitable for participating in the trial due to other conditions, as judged by the researcher;\n* MRI showing that the injury has involved the lateral collateral ligament, with concurrent cartilage damage.","ALL","18 Years",{"count":76,"type":77},24,"ESTIMATED","INTERVENTIONAL",[80,81],"PHASE1","PHASE2","Evaluate the safety and preliminary efficacy of human induced pluripotent stem cell-derived extracellular vesicle (iEV) injection in the treatment of lateral epicondylitis of the humerus.",[84],"Lateral Epicondylitis",[86,87,88,89],"lateral epicondylitis","tennis elbow","induced pluripotent stem cell","extracellularvesicles","2025-08-07",{"date":92,"type":93},"2025-08-08","ACTUAL",{"date":95,"type":93},"2023-07-01",{"date":97,"type":77},"2025-12-31",{"name":5,"class":6},1]