[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564211":3},{"organization":4,"armGroups":7,"interventions":42,"overallOfficials":51,"centralContacts":55,"locations":61,"responsibleParty":85,"collaborators":59,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":59,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":59,"enrollmentInfo":99,"targetDuration":59,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":64,"whyStopped":59,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Emory University","OTHER",[8,14,18,22,26,30,34,38],{"label":9,"type":10,"description":11,"interventionNames":12},"Dose Level 1","EXPERIMENTAL","Participants will receive a supply of curcumin gelatin capsules to insert 500 mg intra-anally every day for a 14-day treatment period",[13],"Drug: Curcuminoid Capsules",{"label":15,"type":10,"description":16,"interventionNames":17},"Dose Level 2","Participants will receive a supply of curcumin gelatin capsules to insert 1000 mg intra-anally every day for a 14-day treatment period",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Dose Level 3","Participants will receive a supply of curcumin gelatin capsules to insert 1500 mg intra-anally every day for a 14-day treatment period",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Dose Level 4","Participants will receive a supply of curcumin gelatin capsules to insert 2000 mg intra-anally every day for a 14-day treatment period",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Dose Level 5","Participants will receive a supply of curcumin gelatin capsules to insert 2500 mg intra-anally every day for a 14-day treatment period",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Dose Level 6","Participants will receive a supply of curcumin gelatin capsules to insert 3000 mg intra-anally every day for a 14-day treatment period",[13],{"label":35,"type":10,"description":36,"interventionNames":37},"Dose Level 7","Participants will receive a supply of curcumin gelatin capsules to insert 3500 mg intra-anally every day for a 14-day treatment period",[13],{"label":39,"type":10,"description":40,"interventionNames":41},"Dose Level 8","Participants will receive a supply of curcumin gelatin capsules to insert 4000 mg intra-anally every day for a 14-day treatment period",[13],[43],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DRUG","Curcuminoid Capsules","500 mg curcuminoids from C3 Complex capsule. Curcuma longa (Turmeric), a constituent of the spice turmeric, is considered a low-toxicity, dietary-derived agent with chemopreventive and therapeutic benefits Study participants will be instructed to insert the curcumin capsules gelatin intra-anally every day for a 14-day treatment period.\n\nEscalating doses",[9,15,19,23,27,31,35,39],[49,50],"Curcumin C3 Complex","Curcuma longa (Turmeric)",[52],{"name":53,"affiliation":5,"role":54},"Lisa Flowers, MD, MPH","PRINCIPAL_INVESTIGATOR",[56],{"name":53,"role":57,"phone":58,"phoneExt":59,"email":60},"CONTACT","404-251-8931",null,"lflowe2@emory.edu",[62,76],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":59},"Grady Memorial Hospital","RECRUITING","Atlanta","Georgia","30303","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-84.38798,33.749,{"lat":74,"lon":73},{"facility":77,"status":64,"city":65,"state":66,"zip":78,"country":68,"countryCode":69,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"Grady Hospital - Ponce De Leon Clinic","30308",{"type":71,"coordinates":80},[73,74],{"lat":74,"lon":73},[83],{"name":84,"role":54,"phone":59,"phoneExt":59,"email":59},"Lisa Flowers, MD",{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":59,"oldOrganization":59},"SPONSOR_INVESTIGATOR","Lisa Flowers","Professor","100564211","phase-1-safety-of-anal-curcumin-100564211",false,"NCT06626230","Safety of Anal Curcumin","An Incremental Dose Escalation Trial of Safety and Tolerability of Curcumin","Major Inclusion Criteria:\n\n* 30 and older\n* Have biopsy-proven anal intraepithelial neoplasia (AIN) 2, AIN 3 without previous treatment\n* Or cytology results for ASC-H or HSIL\n* Able and willing to complete Study Diary\n* Other inclusion criteria apply\n\nExclusion Criteria:\n\n* Have a clinically significant chronic medical condition that is considered progressive, such as but not limited to coronary disease, congestive heart failure, chronic obstructive lung disease, and diabetes mellitus. Chronic nonprogressive or intermittent syndromes are not excluded, including migraine headaches, mild reactive airway disease, controlled hypertension, stable pain syndromes, or benign gastric reflux.\n* Have any history of anal cancer malignancy.\n* Pregnant or planning to become pregnant in the next three months.\n* Have a history of sensitivity or allergy to any compound used in this study.\n* Have Grade 2 or higher renal or hematology abnormality,\n* Are currently using, or in the last year have used intravenous drugs (except for therapeutic use), recreational drugs, or alcohol abuse.\n* Other exclusion criteria apply",true,"ALL","30 Years",{"count":100,"type":101},48,"ESTIMATED","INTERVENTIONAL",[104],"PHASE1","The purpose of this study is to see if curcumin can reverse anal high-grade squamous intraepithelial lesions (aHSIL) (high-grade anal precancerous cells or high-grade abnormal cells) in people living with HIV to avoid current treatments such as ablation (destroying abnormal cells with heat or surgical excision (cutting out the abnormal cells)), which have potential short- and long-term side effects.",[107],"Anal High Grade Squamous Intraepithelial Lesion",[109,110,111,112,113,114],"HSIL\u002FAIN 2-3","Curcumin","Cancer","Human Papillomavirus (HPV)","HIV","Curcuminoids","2026-05-15",{"date":117,"type":118},"2026-05-18","ACTUAL",{"date":120,"type":118},"2025-03-17",{"date":122,"type":101},"2026-07",{"name":87,"class":6},2]