[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624318":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":112,"collaborators":115,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":128,"acronym":25,"eligibilityCriteria":129,"healthyVolunteers":126,"sex":130,"minAge":131,"maxAge":25,"enrollmentInfo":132,"targetDuration":25,"studyType":135,"phases":136,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":151,"whyStopped":25,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sodium Bicarbonate -> Potassium Citrate","EXPERIMENTAL","Receives 1 week of sodium bicarbonate, then 1 week of potassium citrate after washout.",[13,14],"Drug: Potassium Citrate","Drug: Sodium Bicarbonate",{"label":16,"type":10,"description":17,"interventionNames":18},"Potassium Citrate -> Sodium Bicarbonate","1 week of potassium citrate first, then sodium bicarbonate after a washout.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Potassium Citrate","20 mEq Kcit twice a day (40 mEq daily",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sodium Bicarbonate","650 mg sodium bicarbonate twice a day (35.2 mEq daily)",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Kymora B Scotland, MD, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":25,"phoneExt":25,"email":38},"Janelly B Jimenez","CONTACT","JBJimenez@mednet.ucla.edu",[40,52,64,76,89,99],{"facility":5,"status":25,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"Los Angeles","California","90095","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-118.24368,34.05223,{"lat":50,"lon":49},{"facility":53,"status":25,"city":54,"state":42,"zip":55,"country":44,"countryCode":45,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"University of California, Davis","Sacramento","95817",{"type":47,"coordinates":57},[58,59],-121.4944,38.58157,{"lat":59,"lon":58},[62],{"name":63,"role":37,"phone":25,"phoneExt":25,"email":25},"Noah Canvasser",{"facility":65,"status":25,"city":66,"state":42,"zip":67,"country":44,"countryCode":45,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"University of California, San Diego","San Diego","92103",{"type":47,"coordinates":69},[70,71],-117.16472,32.71571,{"lat":71,"lon":70},[74],{"name":75,"role":37,"phone":25,"phoneExt":25,"email":25},"Seth Bechis",{"facility":77,"status":25,"city":78,"state":79,"zip":80,"country":44,"countryCode":45,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Brigham & Women's","Boston","Massachusetts","02115",{"type":47,"coordinates":82},[83,84],-71.05977,42.35843,{"lat":84,"lon":83},[87],{"name":88,"role":37,"phone":25,"phoneExt":25,"email":25},"Daniel Wolen",{"facility":90,"status":25,"city":91,"state":25,"zip":25,"country":92,"countryCode":93,"cosmosGeoPoint":94,"geoPoint":98,"contacts":25},"CHUM","Montreal","Canada","CA",{"type":47,"coordinates":95},[96,97],-73.58781,45.50884,{"lat":97,"lon":96},{"facility":100,"status":25,"city":101,"state":25,"zip":25,"country":102,"countryCode":103,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Landspitali- National University Hospital of Iceland","Reykjavik","Iceland","IS",{"type":47,"coordinates":105},[106,107],-21.89541,64.13548,{"lat":107,"lon":106},[110],{"name":111,"role":37,"phone":25,"phoneExt":25,"email":25},"Johann Ingimarsson",{"type":33,"investigatorFullName":113,"investigatorTitle":114,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Kymora Scotland, MD, PhD","MD, PhD",[116,117,119,121,122],{"name":53,"class":6},{"name":118,"class":6},"Brigham and Women's Hospital",{"name":120,"class":6},"Landspitali University Hospital",{"name":65,"class":6},{"name":123,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","100624318","phase-1-sodium-bicarbonate-as-an-alternative-to-potassium-citrate-for-kidney-stones-100624318",false,"NCT07408076","Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones","Inclusion Criteria:\n\n* Adult \\>18 years of age\n* History of nephrolithiasis\n* One 24h urine collections within one year of enrollment with hypocitraturia.\n* Patients currently utilizing or considering use of Kcit for stone prevention\n\nExclusion Criteria:\n\n* Individuals with known metabolic disorders\n* Individuals with other known causes of nephrolithiasis\n* Anyone who, in the opinion of the PI, is unfit or unsuitable to participate in the study","ALL","18 Years",{"count":133,"type":134},30,"ESTIMATED","INTERVENTIONAL",[137,138],"PHASE1","PHASE2","Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications.\n\nPrescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and\u002For decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied.\n\nThis study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.",[141,142],"Kidney Stones, Urolithiasis, Hypocitraturia","Nephrolithiasis",[144,145,146,147,148,149,150],"kidney stone","stone","calcium oxalate","calcium phosphate","potassium citrate","sodium bicarbonate","nephrolithiasis","NOT_YET_RECRUITING","2026-02-05",{"date":154,"type":155},"2026-02-12","ACTUAL",{"date":157,"type":134},"2026-02-01",{"date":159,"type":134},"2028-02-01",{"name":5,"class":6},6]