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Focal high grade neuroendocrine features are permitted.\n* Measurable PSA ≥ 1 μg\u002FL (≥ 1 ng\u002FmL).\n* Surgically or medically castrated with serum testosterone levels ≤ 50 ng\u002FdL (≤ 1.75 nmol\u002FL) within ≤ 28 days before treatment allocation. 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PSA progression defined by a minimum of 3 rising PSA levels with an interval of ≥ 1 week between each determination. The PSA value at the screening visit should be ≥ 1 μg\u002FL (1 ng\u002FmL).\n  2. Radiographic disease progression in soft tissue based on response evaluation criteria in solid tumors (RECIST) v1.1 criteria with or without PSA progression as per prostate cancer working group 3 (PCWG3).\n  3. 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