[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525962":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":35,"centralContacts":38,"locations":44,"responsibleParty":522,"collaborators":42,"id":524,"slug":525,"hasResults":526,"nctId":527,"briefTitle":528,"officialTitle":529,"acronym":42,"eligibilityCriteria":530,"healthyVolunteers":526,"sex":531,"minAge":532,"maxAge":42,"enrollmentInfo":533,"targetDuration":42,"studyType":536,"phases":537,"briefSummary":540,"conditions":541,"keywords":545,"overallStatus":61,"whyStopped":42,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":592},{"fullName":5,"class":6},"Revolution Medicines, Inc.","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Elironrasib Monotherapy","EXPERIMENTAL","Phase 2 only",[13],"Drug: Elironrasib",{"label":15,"type":10,"description":11,"interventionNames":16},"Daraxonrasib Monotherapy",[17],"Drug: Daraxonrasib",{"label":19,"type":10,"description":20,"interventionNames":21},"Daraxonrasib + Elironrasib Combination","Phase 1b and 2",[13,17],[23,30],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Elironrasib","oral tablets",[19,9],[29],"RMC-6291",{"type":24,"name":31,"description":26,"armGroupLabels":32,"otherNames":33},"Daraxonrasib",[19,15],[34],"RMC-6236",[36],{"name":5,"affiliation":5,"role":37},"STUDY_DIRECTOR",[39],{"name":5,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","1-844-2-REVMED",null,"medinfo@revmed.com",[45,59,69,78,87,97,107,116,126,136,145,154,159,165,175,185,196,205,214,223,228,238,249,258,267,276,285,294,303,312,323,332,341,350,361,370,379,388,397,406,415,426,437,448,454,463,469,475,481,487,495,504,513],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":42},"City of Hope","WITHDRAWN","Duarte","California","91010","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-117.97729,34.13945,{"lat":57,"lon":56},{"facility":60,"status":61,"city":62,"state":49,"zip":63,"country":51,"countryCode":52,"cosmosGeoPoint":64,"geoPoint":68,"contacts":42},"UC IRVINE Health","RECRUITING","Orange","92868",{"type":54,"coordinates":65},[66,67],-117.85311,33.78779,{"lat":67,"lon":66},{"facility":70,"status":61,"city":71,"state":49,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":73,"geoPoint":77,"contacts":42},"UC Davis Comprehensive Cancer Center","Sacramento","95817",{"type":54,"coordinates":74},[75,76],-121.4944,38.58157,{"lat":76,"lon":75},{"facility":79,"status":61,"city":80,"state":49,"zip":81,"country":51,"countryCode":52,"cosmosGeoPoint":82,"geoPoint":86,"contacts":42},"Stanford Cancer Institute","Stanford","94305",{"type":54,"coordinates":83},[84,85],-122.16608,37.42411,{"lat":85,"lon":84},{"facility":88,"status":61,"city":89,"state":90,"zip":91,"country":51,"countryCode":52,"cosmosGeoPoint":92,"geoPoint":96,"contacts":42},"University of Colorado Cancer Center","Aurora","Colorado","80045",{"type":54,"coordinates":93},[94,95],-104.83192,39.72943,{"lat":95,"lon":94},{"facility":98,"status":61,"city":99,"state":100,"zip":101,"country":51,"countryCode":52,"cosmosGeoPoint":102,"geoPoint":106,"contacts":42},"Florida Cancer Specialists","Sarasota","Florida","34232",{"type":54,"coordinates":103},[104,105],-82.53065,27.33643,{"lat":105,"lon":104},{"facility":108,"status":61,"city":109,"state":100,"zip":110,"country":51,"countryCode":52,"cosmosGeoPoint":111,"geoPoint":115,"contacts":42},"Moffitt Cancer Center and Research Institute","Tampa","33612",{"type":54,"coordinates":112},[113,114],-82.45843,27.94752,{"lat":114,"lon":113},{"facility":117,"status":61,"city":118,"state":119,"zip":120,"country":51,"countryCode":52,"cosmosGeoPoint":121,"geoPoint":125,"contacts":42},"Dana Farber Cancer Institute","Boston","Massachusetts","02215",{"type":54,"coordinates":122},[123,124],-71.05977,42.35843,{"lat":124,"lon":123},{"facility":127,"status":47,"city":128,"state":129,"zip":130,"country":51,"countryCode":52,"cosmosGeoPoint":131,"geoPoint":135,"contacts":42},"Henry Ford Cancer","Detroit","Michigan","48202",{"type":54,"coordinates":132},[133,134],-83.04575,42.33143,{"lat":134,"lon":133},{"facility":137,"status":61,"city":138,"state":129,"zip":139,"country":51,"countryCode":52,"cosmosGeoPoint":140,"geoPoint":144,"contacts":42},"START Midwest","Grand Rapids","49546",{"type":54,"coordinates":141},[142,143],-85.66809,42.96336,{"lat":143,"lon":142},{"facility":146,"status":61,"city":147,"state":147,"zip":148,"country":51,"countryCode":52,"cosmosGeoPoint":149,"geoPoint":153,"contacts":42},"Columbia University","New York","10032",{"type":54,"coordinates":150},[151,152],-74.00597,40.71427,{"lat":152,"lon":151},{"facility":155,"status":61,"city":147,"state":147,"zip":148,"country":51,"countryCode":52,"cosmosGeoPoint":156,"geoPoint":158,"contacts":42},"NYU Langone Health",{"type":54,"coordinates":157},[151,152],{"lat":152,"lon":151},{"facility":160,"status":61,"city":147,"state":147,"zip":161,"country":51,"countryCode":52,"cosmosGeoPoint":162,"geoPoint":164,"contacts":42},"Memorial Sloan Kettering Cancer Center","10065",{"type":54,"coordinates":163},[151,152],{"lat":152,"lon":151},{"facility":166,"status":61,"city":167,"state":168,"zip":169,"country":51,"countryCode":52,"cosmosGeoPoint":170,"geoPoint":174,"contacts":42},"University of Oklahoma","Oklahoma City","Oklahoma","73104",{"type":54,"coordinates":171},[172,173],-97.51643,35.46756,{"lat":173,"lon":172},{"facility":176,"status":61,"city":177,"state":178,"zip":179,"country":51,"countryCode":52,"cosmosGeoPoint":180,"geoPoint":184,"contacts":42},"Sarah Cannon Research Institue","Nashville","Tennessee","37203",{"type":54,"coordinates":181},[182,183],-86.78444,36.16589,{"lat":183,"lon":182},{"facility":186,"status":187,"city":188,"state":189,"zip":190,"country":51,"countryCode":52,"cosmosGeoPoint":191,"geoPoint":195,"contacts":42},"Mary Crowley Cancer Research","COMPLETED","Dallas","Texas","75230",{"type":54,"coordinates":192},[193,194],-96.80667,32.78306,{"lat":194,"lon":193},{"facility":197,"status":61,"city":198,"state":189,"zip":199,"country":51,"countryCode":52,"cosmosGeoPoint":200,"geoPoint":204,"contacts":42},"MD Anderson","Houston","77030",{"type":54,"coordinates":201},[202,203],-95.36327,29.76328,{"lat":203,"lon":202},{"facility":206,"status":61,"city":207,"state":189,"zip":208,"country":51,"countryCode":52,"cosmosGeoPoint":209,"geoPoint":213,"contacts":42},"NEXT Dallas","Irving","75039",{"type":54,"coordinates":210},[211,212],-96.94889,32.81402,{"lat":212,"lon":211},{"facility":215,"status":61,"city":216,"state":189,"zip":217,"country":51,"countryCode":52,"cosmosGeoPoint":218,"geoPoint":222,"contacts":42},"NEXT Oncology San Antonio","San Antonio","78229",{"type":54,"coordinates":219},[220,221],-98.49363,29.42412,{"lat":221,"lon":220},{"facility":224,"status":61,"city":216,"state":189,"zip":217,"country":51,"countryCode":52,"cosmosGeoPoint":225,"geoPoint":227,"contacts":42},"START Texas",{"type":54,"coordinates":226},[220,221],{"lat":221,"lon":220},{"facility":229,"status":61,"city":230,"state":231,"zip":232,"country":51,"countryCode":52,"cosmosGeoPoint":233,"geoPoint":237,"contacts":42},"NEXT Oncology Virginia","Fairfax","Virginia","22031",{"type":54,"coordinates":234},[235,236],-77.30637,38.84622,{"lat":236,"lon":235},{"facility":239,"status":61,"city":240,"state":42,"zip":241,"country":242,"countryCode":243,"cosmosGeoPoint":244,"geoPoint":248,"contacts":42},"West Cancer Institute","Angers","49055","France","FR",{"type":54,"coordinates":245},[246,247],-0.55202,47.47156,{"lat":247,"lon":246},{"facility":250,"status":61,"city":251,"state":42,"zip":252,"country":242,"countryCode":243,"cosmosGeoPoint":253,"geoPoint":257,"contacts":42},"Institut Bergonie","Bordeaux","33000",{"type":54,"coordinates":254},[255,256],-0.58046,44.84124,{"lat":256,"lon":255},{"facility":259,"status":61,"city":260,"state":42,"zip":261,"country":242,"countryCode":243,"cosmosGeoPoint":262,"geoPoint":266,"contacts":42},"Hospital Louise Pradel","Bron","69500",{"type":54,"coordinates":263},[264,265],4.91303,45.73865,{"lat":265,"lon":264},{"facility":268,"status":61,"city":269,"state":42,"zip":270,"country":242,"countryCode":243,"cosmosGeoPoint":271,"geoPoint":275,"contacts":42},"Oscar Lambret Center of Lillle","Lille","59000",{"type":54,"coordinates":272},[273,274],3.05512,50.63391,{"lat":274,"lon":273},{"facility":277,"status":61,"city":278,"state":42,"zip":279,"country":242,"countryCode":243,"cosmosGeoPoint":280,"geoPoint":284,"contacts":42},"Centre Leon Berard","Lyon","69373",{"type":54,"coordinates":281},[282,283],4.84789,45.74906,{"lat":283,"lon":282},{"facility":286,"status":61,"city":287,"state":42,"zip":288,"country":242,"countryCode":243,"cosmosGeoPoint":289,"geoPoint":293,"contacts":42},"Cancer Institute of Montpellier","Montpellier","34298",{"type":54,"coordinates":290},[291,292],3.87635,43.61093,{"lat":292,"lon":291},{"facility":295,"status":61,"city":296,"state":42,"zip":297,"country":242,"countryCode":243,"cosmosGeoPoint":298,"geoPoint":302,"contacts":42},"CHU Nantes","Nantes","44093",{"type":54,"coordinates":299},[300,301],-1.55336,47.21725,{"lat":301,"lon":300},{"facility":304,"status":47,"city":305,"state":42,"zip":306,"country":242,"countryCode":243,"cosmosGeoPoint":307,"geoPoint":311,"contacts":42},"Institute of Cancer of Strasbourg","Strasbourg","67033",{"type":54,"coordinates":308},[309,310],7.74553,48.58392,{"lat":310,"lon":309},{"facility":313,"status":61,"city":314,"state":42,"zip":315,"country":316,"countryCode":317,"cosmosGeoPoint":318,"geoPoint":322,"contacts":42},"Universitäts Klinikum Köln","Cologne","80937","Germany","DE",{"type":54,"coordinates":319},[320,321],6.95,50.93333,{"lat":321,"lon":320},{"facility":324,"status":61,"city":325,"state":42,"zip":326,"country":316,"countryCode":317,"cosmosGeoPoint":327,"geoPoint":331,"contacts":42},"Klinikum Esslingen GmbH","Esslingen am Neckar","73730",{"type":54,"coordinates":328},[329,330],9.30473,48.73961,{"lat":330,"lon":329},{"facility":333,"status":61,"city":334,"state":42,"zip":335,"country":316,"countryCode":317,"cosmosGeoPoint":336,"geoPoint":340,"contacts":42},"Krankenhaus Bethanien Moers","Moers","47441",{"type":54,"coordinates":337},[338,339],6.6326,51.45342,{"lat":339,"lon":338},{"facility":342,"status":61,"city":343,"state":42,"zip":344,"country":316,"countryCode":317,"cosmosGeoPoint":345,"geoPoint":349,"contacts":42},"Klinkum Nurnberg Paracelsus Medical Unviersity","Nuremberg","90419",{"type":54,"coordinates":346},[347,348],11.07752,49.45421,{"lat":348,"lon":347},{"facility":351,"status":61,"city":352,"state":42,"zip":353,"country":354,"countryCode":355,"cosmosGeoPoint":356,"geoPoint":360,"contacts":42},"Department of Medical Oncology - Azienda Ospedaliero Uniersitaria delle Marche","Ancona","60126","Italy","IT",{"type":54,"coordinates":357},[358,359],13.5103,43.60717,{"lat":359,"lon":358},{"facility":362,"status":61,"city":363,"state":42,"zip":364,"country":354,"countryCode":355,"cosmosGeoPoint":365,"geoPoint":369,"contacts":42},"Centro Di Riferimento Oncologico","Aviano","33081",{"type":54,"coordinates":366},[367,368],12.59472,46.07056,{"lat":368,"lon":367},{"facility":371,"status":61,"city":372,"state":42,"zip":373,"country":354,"countryCode":355,"cosmosGeoPoint":374,"geoPoint":378,"contacts":42},"Institute Romagnolo per lo Studio Tumori","Meldola","47014",{"type":54,"coordinates":375},[376,377],12.0626,44.12775,{"lat":377,"lon":376},{"facility":380,"status":61,"city":381,"state":42,"zip":382,"country":354,"countryCode":355,"cosmosGeoPoint":383,"geoPoint":387,"contacts":42},"Niguarda Cancer Center","Milan","20162",{"type":54,"coordinates":384},[385,386],12.59836,42.78235,{"lat":386,"lon":385},{"facility":389,"status":61,"city":390,"state":42,"zip":391,"country":354,"countryCode":355,"cosmosGeoPoint":392,"geoPoint":396,"contacts":42},"Istituto Nazionale Tumori IRCCS Fondazione \"G. Pascale\"","Naples","80131",{"type":54,"coordinates":393},[394,395],14.26811,40.85216,{"lat":395,"lon":394},{"facility":398,"status":61,"city":399,"state":42,"zip":400,"country":354,"countryCode":355,"cosmosGeoPoint":401,"geoPoint":405,"contacts":42},"San Luigi Hospital","Orbassano","10043",{"type":54,"coordinates":402},[403,404],7.53813,45.00547,{"lat":404,"lon":403},{"facility":407,"status":61,"city":408,"state":42,"zip":409,"country":354,"countryCode":355,"cosmosGeoPoint":410,"geoPoint":414,"contacts":42},"AUSL Romagna - S.M. delle Croci Hospital","Ravenna","48121",{"type":54,"coordinates":411},[412,413],12.20121,44.41344,{"lat":413,"lon":412},{"facility":416,"status":61,"city":417,"state":42,"zip":418,"country":419,"countryCode":420,"cosmosGeoPoint":421,"geoPoint":425,"contacts":42},"Netherlands Cancer Institute Antoni van Leeuwenhoek","Amsterdam","1066CX","Netherlands","NL",{"type":54,"coordinates":422},[423,424],4.88969,52.37403,{"lat":424,"lon":423},{"facility":427,"status":61,"city":428,"state":42,"zip":429,"country":430,"countryCode":431,"cosmosGeoPoint":432,"geoPoint":436,"contacts":42},"Pan American Center for Oncology Trials","San Juan","00935","Puerto Rico","PR",{"type":54,"coordinates":433},[434,435],-66.10572,18.46633,{"lat":435,"lon":434},{"facility":438,"status":61,"city":439,"state":42,"zip":440,"country":441,"countryCode":442,"cosmosGeoPoint":443,"geoPoint":447,"contacts":42},"START Barcelona - Hospital HM Nou Delfos","Barcelona","08023","Spain","ES",{"type":54,"coordinates":444},[445,446],2.15899,41.38879,{"lat":446,"lon":445},{"facility":449,"status":61,"city":439,"state":42,"zip":450,"country":441,"countryCode":442,"cosmosGeoPoint":451,"geoPoint":453,"contacts":42},"Institut Catala d'Oncologia Hospital","08908",{"type":54,"coordinates":452},[445,446],{"lat":446,"lon":445},{"facility":455,"status":61,"city":456,"state":42,"zip":457,"country":441,"countryCode":442,"cosmosGeoPoint":458,"geoPoint":462,"contacts":42},"University Clinic of Navarra","Madrid","28027",{"type":54,"coordinates":459},[460,461],-3.70256,40.4165,{"lat":461,"lon":460},{"facility":464,"status":61,"city":456,"state":42,"zip":465,"country":441,"countryCode":442,"cosmosGeoPoint":466,"geoPoint":468,"contacts":42},"Fundacion MD Anderson Cancer Center","28033",{"type":54,"coordinates":467},[460,461],{"lat":461,"lon":460},{"facility":470,"status":61,"city":456,"state":42,"zip":471,"country":441,"countryCode":442,"cosmosGeoPoint":472,"geoPoint":474,"contacts":42},"START Madrid","28040",{"type":54,"coordinates":473},[460,461],{"lat":461,"lon":460},{"facility":476,"status":61,"city":456,"state":42,"zip":477,"country":441,"countryCode":442,"cosmosGeoPoint":478,"geoPoint":480,"contacts":42},"Hospital Universitario 12 de Octubre","28041",{"type":54,"coordinates":479},[460,461],{"lat":461,"lon":460},{"facility":482,"status":61,"city":456,"state":42,"zip":483,"country":441,"countryCode":442,"cosmosGeoPoint":484,"geoPoint":486,"contacts":42},"NEXT Oncology - Quirónsalud Madrid University Hospital","28223",{"type":54,"coordinates":485},[460,461],{"lat":461,"lon":460},{"facility":455,"status":61,"city":488,"state":42,"zip":489,"country":441,"countryCode":442,"cosmosGeoPoint":490,"geoPoint":494,"contacts":42},"Pamplona","31008",{"type":54,"coordinates":491},[492,493],-1.64323,42.81687,{"lat":493,"lon":492},{"facility":496,"status":61,"city":497,"state":42,"zip":498,"country":441,"countryCode":442,"cosmosGeoPoint":499,"geoPoint":503,"contacts":42},"Hospital Universitario Virgen Macarena","Seville","41009",{"type":54,"coordinates":500},[501,502],-5.97317,37.38283,{"lat":502,"lon":501},{"facility":505,"status":61,"city":506,"state":42,"zip":507,"country":441,"countryCode":442,"cosmosGeoPoint":508,"geoPoint":512,"contacts":42},"La Fe University and Polytechnic Hospital","Valencia","46026",{"type":54,"coordinates":509},[510,511],-0.37966,39.47391,{"lat":511,"lon":510},{"facility":514,"status":61,"city":515,"state":42,"zip":516,"country":441,"countryCode":442,"cosmosGeoPoint":517,"geoPoint":521,"contacts":42},"Hospital Universitario Miguel Servet","Zaragoza","50009",{"type":54,"coordinates":518},[519,520],-0.87734,41.65606,{"lat":520,"lon":519},{"type":523,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100525962","phase-1-study-of-elironrasib-and-daraxonrasib-as-monotherapies-and-combination-therapy-in-participants-with-advanced-kras-g12c-mutant-solid-tumors-100525962",false,"NCT06128551","Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors","Phase 1b\u002F2, Multicenter, Open-label, Dose Escalation and Dose Expansion Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Patients With Advanced KRAS G12C-Mutated Solid Tumors","Inclusion Criteria:\n\n* 18 years of age\n* Histology: pathologically documented, KRAS G12C-mutated, advanced or metastatic solid tumors not amendable to curative therapy\n\n  1. Phase 1b Dose Escalation: solid tumors, previously treated\n  2. Phase 1b Dose Expansion and Phase 2:\n\n  i. NSCLC, previously treated with immunotherapy, chemotherapy, and KRAS G12C (OFF) inhibitors ii. Solid tumors, previously treated, naïve to KRAS G12C (OFF) inhibitors.\n* ECOG performance status 0 or 1\n* Adequate organ function\n\nExclusion Criteria:\n\n* Primary central nervous system (CNS) tumors\n* Active brain metastases\n* Known impairment of GI function that would alter the absorption\n* Major surgical procedures within 28 days or non-study related minor procedures within 7 days of treatment","ALL","18 Years",{"count":534,"type":535},534,"ESTIMATED","INTERVENTIONAL",[538,539],"PHASE1","PHASE2","This study is to evaluate the safety, tolerability, and PK profiles of Elironrasib and Daraxonrasib as monotherapies and combination therapy in patients with KRAS G12C-mutated solid tumors.",[542,543,544],"Non-Small Cell Lung Cancer (NSCLC)","Colorectal Cancer","Pancreatic Ductal Adenocarcinoma",[29,546,547,548,549,550,551,552,553,554,555,556,557,543,558,559,560,561,562,563,564,565,566,567,568,569,570,571,572,573,574,575,576,577,578,579,580,581,582,34,25,31],"RAS (ON)","KRAS","KRASG12C","KRASG12C (ON)","Targeted therapy","Metastatic Cancer","Lung Cancer","Lung Neoplasms","Thoracic Neoplasms","Non-small Cell Lung Cancer","Carcinoma, Non-Small Cell Lung","NSCLC","Colonic Neoplasms","CRC","Appendiceal Cancer","KRAS mutation","STK11\u002FLKB1","KEAP1","Bronchial neoplasms","Respiratory tract neoplasms","Neoplasms by site","Neoplasms","Colon Cancer","Rectal Cancer","Lung disease","Respiratory tract diseases","Pancreatic Cancer","Carcinoma, Pancreatic Ductal","PDAC","Gastrointestinal Neoplasms","Intestinal Neoplasms","Esophageal Cancer","Ampullary Cancer","Gastric Cancer","Gynecological Cancer","Ovarian Cancer","Endometrial Cancer","2026-04-20",{"date":585,"type":586},"2026-04-23","ACTUAL",{"date":588,"type":586},"2023-11-14",{"date":590,"type":535},"2029-06",{"name":5,"class":6},53]