[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468454":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":24,"locations":29,"responsibleParty":229,"collaborators":20,"id":231,"slug":232,"hasResults":233,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":20,"eligibilityCriteria":237,"healthyVolunteers":233,"sex":238,"minAge":239,"maxAge":20,"enrollmentInfo":240,"targetDuration":20,"studyType":243,"phases":244,"briefSummary":247,"conditions":248,"keywords":253,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":288},{"fullName":5,"class":6},"Revolution Medicines, Inc.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: RMC-6236","EXPERIMENTAL","Enrollment into dose exploration may be from any advanced solid tumor type with KRAS p.G12 mutations.\n\nEnrollment into dose expansion\u002Foptimization may be from groups consisting of patients with a single histotype\u002Fgenotype (for example, KRAS G12-mutated NSCLC, PDAC, CRC, RAS mutant NSCLC, Melanoma, gynecological cancer or other solid tumors not previously specified).\n\nRAS mutant is defined as any nonsynonymous mutation of KRAS, NRAS, or HRAS at codons 12, 13, or 61 (G12, G13, or Q61)",[13],"Drug: RMC-6236",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","RMC-6236","Oral Tablets",[9],null,[22],{"name":5,"affiliation":5,"role":23},"STUDY_DIRECTOR",[25],{"name":5,"role":26,"phone":27,"phoneExt":20,"email":28},"CONTACT","1-844-273-8633","medinfo@revmed.com",[30,44,53,63,73,83,93,103,112,118,124,134,143,153,162,172,181,190,199,209,219],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":20},"UC Irvine\u002FChao Family Comprehensive Cancer Center","RECRUITING","Orange","California","92868","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-117.85311,33.78779,{"lat":42,"lon":41},{"facility":45,"status":32,"city":46,"state":34,"zip":47,"country":36,"countryCode":37,"cosmosGeoPoint":48,"geoPoint":52,"contacts":20},"UCLA","Santa Monica","90404",{"type":39,"coordinates":49},[50,51],-118.49138,34.01949,{"lat":51,"lon":50},{"facility":54,"status":32,"city":55,"state":56,"zip":57,"country":36,"countryCode":37,"cosmosGeoPoint":58,"geoPoint":62,"contacts":20},"Moffitt Cancer Center","Tampa","Florida","33612",{"type":39,"coordinates":59},[60,61],-82.45843,27.94752,{"lat":61,"lon":60},{"facility":64,"status":32,"city":65,"state":66,"zip":67,"country":36,"countryCode":37,"cosmosGeoPoint":68,"geoPoint":72,"contacts":20},"Piedmont Healthcare","Atlanta","Georgia","30318",{"type":39,"coordinates":69},[70,71],-84.38798,33.749,{"lat":71,"lon":70},{"facility":74,"status":32,"city":75,"state":76,"zip":77,"country":36,"countryCode":37,"cosmosGeoPoint":78,"geoPoint":82,"contacts":20},"Mary Bird Perkins Cancer Center","Baton Rouge","Louisiana","70809",{"type":39,"coordinates":79},[80,81],-91.18747,30.44332,{"lat":81,"lon":80},{"facility":84,"status":32,"city":85,"state":86,"zip":87,"country":36,"countryCode":37,"cosmosGeoPoint":88,"geoPoint":92,"contacts":20},"Johns Hopkins University","Baltimore","Maryland","21287",{"type":39,"coordinates":89},[90,91],-76.61219,39.29038,{"lat":91,"lon":90},{"facility":94,"status":32,"city":95,"state":96,"zip":97,"country":36,"countryCode":37,"cosmosGeoPoint":98,"geoPoint":102,"contacts":20},"Dana Farber Cancer Institute","Boston","Massachusetts","02215",{"type":39,"coordinates":99},[100,101],-71.05977,42.35843,{"lat":101,"lon":100},{"facility":104,"status":32,"city":105,"state":105,"zip":106,"country":36,"countryCode":37,"cosmosGeoPoint":107,"geoPoint":111,"contacts":20},"Perlmutter Cancer Center at NYU Langone Health","New York","10016",{"type":39,"coordinates":108},[109,110],-74.00597,40.71427,{"lat":110,"lon":109},{"facility":113,"status":32,"city":105,"state":105,"zip":114,"country":36,"countryCode":37,"cosmosGeoPoint":115,"geoPoint":117,"contacts":20},"Memorial Sloan-Kettering Cancer Center","10021",{"type":39,"coordinates":116},[109,110],{"lat":110,"lon":109},{"facility":119,"status":32,"city":105,"state":105,"zip":120,"country":36,"countryCode":37,"cosmosGeoPoint":121,"geoPoint":123,"contacts":20},"Columbia University","10032",{"type":39,"coordinates":122},[109,110],{"lat":110,"lon":109},{"facility":125,"status":32,"city":126,"state":127,"zip":128,"country":36,"countryCode":37,"cosmosGeoPoint":129,"geoPoint":133,"contacts":20},"Christ Hospital Cancer Center","Cincinnati","Ohio","45219",{"type":39,"coordinates":130},[131,132],-84.51439,39.12711,{"lat":132,"lon":131},{"facility":135,"status":32,"city":136,"state":127,"zip":137,"country":36,"countryCode":37,"cosmosGeoPoint":138,"geoPoint":142,"contacts":20},"Taylor Cancer Research Center","Maumee","43537",{"type":39,"coordinates":139},[140,141],-83.65382,41.56283,{"lat":141,"lon":140},{"facility":144,"status":32,"city":145,"state":146,"zip":147,"country":36,"countryCode":37,"cosmosGeoPoint":148,"geoPoint":152,"contacts":20},"Tennessee Oncology","Chattanooga","Tennessee","37404",{"type":39,"coordinates":149},[150,151],-85.30968,35.04563,{"lat":151,"lon":150},{"facility":154,"status":32,"city":155,"state":146,"zip":156,"country":36,"countryCode":37,"cosmosGeoPoint":157,"geoPoint":161,"contacts":20},"Sarah Cannon Research Institute","Nashville","37203",{"type":39,"coordinates":158},[159,160],-86.78444,36.16589,{"lat":160,"lon":159},{"facility":163,"status":32,"city":164,"state":165,"zip":166,"country":36,"countryCode":37,"cosmosGeoPoint":167,"geoPoint":171,"contacts":20},"University of Texas at Austin","Austin","Texas","78712",{"type":39,"coordinates":168},[169,170],-97.74306,30.26715,{"lat":170,"lon":169},{"facility":173,"status":32,"city":174,"state":165,"zip":175,"country":36,"countryCode":37,"cosmosGeoPoint":176,"geoPoint":180,"contacts":20},"Mary Crowley Cancer Research","Dallas","75230",{"type":39,"coordinates":177},[178,179],-96.80667,32.78306,{"lat":179,"lon":178},{"facility":182,"status":32,"city":183,"state":165,"zip":184,"country":36,"countryCode":37,"cosmosGeoPoint":185,"geoPoint":189,"contacts":20},"The University of Texas MD Anderson Cancer Center","Houston","77030",{"type":39,"coordinates":186},[187,188],-95.36327,29.76328,{"lat":188,"lon":187},{"facility":191,"status":32,"city":192,"state":165,"zip":193,"country":36,"countryCode":37,"cosmosGeoPoint":194,"geoPoint":198,"contacts":20},"Next Oncology","San Antonio","78229",{"type":39,"coordinates":195},[196,197],-98.49363,29.42412,{"lat":197,"lon":196},{"facility":200,"status":32,"city":201,"state":202,"zip":203,"country":36,"countryCode":37,"cosmosGeoPoint":204,"geoPoint":208,"contacts":20},"Huntsman Cancer Institute","Salt Lake City","Utah","84112",{"type":39,"coordinates":205},[206,207],-111.89105,40.76078,{"lat":207,"lon":206},{"facility":210,"status":32,"city":211,"state":212,"zip":213,"country":36,"countryCode":37,"cosmosGeoPoint":214,"geoPoint":218,"contacts":20},"Next Oncology Virginia","Fairfax","Virginia","22031",{"type":39,"coordinates":215},[216,217],-77.30637,38.84622,{"lat":217,"lon":216},{"facility":220,"status":32,"city":221,"state":222,"zip":223,"country":36,"countryCode":37,"cosmosGeoPoint":224,"geoPoint":228,"contacts":20},"Virginia Mason Medical Center","Seattle","Washington","98101",{"type":39,"coordinates":225},[226,227],-122.33207,47.60621,{"lat":227,"lon":226},{"type":230,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100468454","phase-1-study-of-rmc-6236-in-patients-with-advanced-solid-tumors-harboring-specific-mutations-in-ras-100468454",false,"NCT05379985","Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS","A Multicenter Open-Label Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS","Inclusion Criteria:\n\n* Histologically confirmed advanced solid tumor with specific KRAS G12 mutations (dose escalation) or RAS mutations (dose optimization\u002Fexpansion) identified through deoxyribonucleic acid (DNA) sequencing. PDAC with wild-type RAS (expansion).\n* Treatment naive or have received prior standard therapy appropriate for tumor type and stage\n* Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1\n* Adequate organ function\n\nExclusion Criteria:\n\n* Primary central nervous system (CNS) tumors\n* Active, untreated brain metastases\n* Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication\n* History of any other unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the safety of a participant, impact their expected survival through the end of the study participation, and\u002For impact their ability to comply with the protocol prior\u002Fconcomitant therapy\n\nOther inclusion\u002Fexclusion criteria may apply.","ALL","18 Years",{"count":241,"type":242},754,"ESTIMATED","INTERVENTIONAL",[245,246],"PHASE1","PHASE2","Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors.",[249,250,251,252],"Non-small Cell Lung Cancer (NSCLC)","Colorectal Cancer (CRC)","Pancreatic Ductal Adenocarcinoma (PDAC)","Advanced Solid Tumors",[254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278],"KRAS","Non-small Cell Lung Cancer","Lung Cancer","Colorectal Cancer","Colon Cancer","Metastatic Cancer","Pancreatic Cancer","Pancreatic Ductal Adenocarcinoma","NSCLC","CRC","PDAC","Pancreatic Neoplasms","Carcinoma, Pancreatic Ductal","Colorectal Neoplasms","Colonic Neoplasms","Intestinal Neoplasms","Gastrointestinal Neoplasms","Lung Neoplasms","Carcinoma, Non-Small-Cell Lung","Neoplastic Processes","Thoracic Neoplasms","Antineoplastic Agents","Melanoma","Gynecological Cancers","RAS","2026-05-12",{"date":281,"type":282},"2026-05-15","ACTUAL",{"date":284,"type":282},"2022-05-31",{"date":286,"type":242},"2027-07-26",{"name":5,"class":6},21]