[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549158":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":27,"locations":33,"responsibleParty":49,"collaborators":21,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":21,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":21,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":21,"overallStatus":35,"whyStopped":21,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Institute of Automation, Chinese Academy of Sciences","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Bev-ICG NIR-II Endoscopy","EXPERIMENTAL","The patients will receive a topical administration of probe (Bev-ICG) during the endoscopy. Then fluorescence imaging will be performed to guide the detection.",[13,14],"Drug: Bev-ICG","Device: NIR-II fluorescence endoscopy platform",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Bev-ICG","Probe targeting VEGF-A that is topically administrated during the endoscopy",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DEVICE","NIR-II fluorescence endoscopy platform","An endoscopic detection device which can detect and visualize NIR-II fluorescent signal during the endoscopy",[9],[28],{"name":29,"role":30,"phone":31,"phoneExt":21,"email":32},"Lidan Fu","CONTACT","17754927702","fulidan2021@ia.ac.cn",[34],{"facility":29,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Beijing","Beijing Municipality","100190","China","CN",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},[48],{"name":29,"role":30,"phone":31,"phoneExt":21,"email":32},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Zhenhua Hu","Professor","100549158","phase-1-study-of-vegf-a-targeting-nir-ii-fluorescence-endoscopy-in-the-gastrointestinal-tract-100549158",false,"NCT06430372","Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract","Study of Vascular Endothelial Growth Factor A Targeting NIR-II Fluorescence in the Endoscopy of Gastrointestinal Tract","Inclusion Criteria:\n\n* Known or suspected gastrointestinal lesions.\n* Scheduled for a clinically-indicated endoscopy.\n* Mentally competent person, 18 years or older.\n* Approved to sign the informed consent.\n* Adequate potential for follow-up.\n\nExclusion Criteria:\n\n* Subjects with known allergy or negative reaction to ICG or derivatives.\n* Undesirable function of heart, lung, kidney, or any other organs.\n* Enrolled in other trials in the past 3 months.\n* Pregnant or trying to conceive.\n* Unable to tolerate an endoscopy.\n* Medical or psychiatric conditions that compromise the patient's ability to give informed consent.\n* The researchers considered inappropriate to be included.","ALL","18 Years","75 Years",{"count":64,"type":65},30,"ESTIMATED","INTERVENTIONAL",[68],"PHASE1","In this study, the investigators are studying new ways to look for abnormal tissues of the gastrointestinal tract during an endoscopy. We are using a VEGF-A targeting fluorescent probe and a NIR-II fluorescent endoscope to help detect abnormal tissues that are hard to see by the naked eye.\n\nThe main purposes of this study include:\n\n1. To translate the NIR-II approach into the endoscopy, and understand its advantages and limitations on detecting abnormal tissues in gastrointestinal.\n2. To validate whether topical administration of a targeting probe can stick to abnormal tissues and be detected by the NIR-II endoscope.\n3. To validate the safety and effectiveness of the topical administration of VEGF-A targeting probes for clinical application.",[71,72,73],"Gastrointestinal Carcinoma","Dysplasia","Gastrointestinal Polyp","2025-05-08",{"date":76,"type":77},"2025-05-13","ACTUAL",{"date":79,"type":77},"2023-07-20",{"date":81,"type":65},"2026-05-30",{"name":5,"class":6},1]