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Lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.\n* Subjects who have relapsed and refractory ccRCC, pRCC, NSCLC, and CRC with evidence of disease progression on standard-of-care therapies\n* ECOG performance status of 0 or 1.\n* All subjects must have adequate tumor sample available (slides or archival FFPE blocks)\n\nExclusion Criteria:\n\n* Prior treatment with an investigational anti-ENPP3\u002FCD203c therapy\n* History of serious allergic or anaphylactic\u002Fhypersensitivity reaction to monoclonal antibody therapy\n* Systemic antineoplastic therapy within 5 half-lives on the first dose of study treatment.\n* Failure to recover from any clinically significant toxicity related to previous anticancer treatment\n* Have known active central nervous system metastases and\u002For carcinomatous meningitis. Subjects with previously treated brain metastases may participate provided they are radiologically stable,\n* Active known autoimmune disease (except that subjects are permitted to enroll if they have vitiligo; type 1 diabetes mellitus; residual hypothyroidism due to an autoimmune condition that is treatable with hormone replacement therapy only; psoriasis, atopic dermatitis, or another autoimmune skin condition that is managed without systemic therapy; or arthritis that is managed without systemic therapy beyond oral acetaminophen and nonsteroidal anti-inflammatory drugs)\n* Evidence of any serious infection requiring IV anti-infective treatment within 14 days prior to the first dose of study drug\n* Have a known additional malignancy that is progressing or has required active treatment within the past 2 years","ALL","18 Years",{"count":274,"type":275},307,"ESTIMATED","INTERVENTIONAL",[278],"PHASE1","The purpose of this study is to assess the safety and tolerability of XmAb®819 administered intravenous (IV) or subcutaneous (SC) in subjects with relapsed or refractory clear cell renal cell carcinoma and to identify the minimum safe and biologically active dose and the recommended dose (RD).",[281],"Clear Cell Renal Cell Carcinoma",[283,284,285,286,287,288],"Clear cell Papillary","RCC","Renal Cell Cancer","Kidney Cancer","Lung Cancer","Colon Cancer","2026-06-09",{"date":291,"type":292},"2026-06-11","ACTUAL",{"date":294,"type":292},"2022-06-13",{"date":296,"type":275},"2028-12",{"name":5,"class":6},26]