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268684","Meldola","Forlì-Cesena","47014","Italy","IT",{"type":81,"coordinates":656},[657,658],12.0626,44.12775,{"lat":658,"lon":657},{"facility":661,"status":88,"city":662,"state":663,"zip":664,"country":653,"countryCode":654,"cosmosGeoPoint":665,"geoPoint":669,"contacts":49},"Istituto Europeo Di Oncologia \u002FId# 268670","Milan","Milano","20121",{"type":81,"coordinates":666},[667,668],9.18951,45.46427,{"lat":668,"lon":667},{"facility":671,"status":88,"city":672,"state":673,"zip":674,"country":653,"countryCode":654,"cosmosGeoPoint":675,"geoPoint":679,"contacts":49},"IRCCS Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena \u002FID# 268626","Rome","Roma","00144",{"type":81,"coordinates":676},[677,678],12.51133,41.89193,{"lat":678,"lon":677},{"facility":681,"status":88,"city":682,"state":683,"zip":684,"country":653,"countryCode":654,"cosmosGeoPoint":685,"geoPoint":689,"contacts":49},"Azienda Ospedaliero Universitaria San Luigi Gonzaga \u002FID# 268641","Orbassano","Torino","10043",{"type":81,"coordinates":686},[687,688],7.53813,45.00547,{"lat":688,"lon":687},{"facility":691,"status":88,"city":692,"state":49,"zip":693,"country":653,"countryCode":654,"cosmosGeoPoint":694,"geoPoint":698,"contacts":49},"Azienda Ospedaliero Universitaria delle Marche \u002FID# 268667","Ancona","60126",{"type":81,"coordinates":695},[696,697],13.5103,43.60717,{"lat":697,"lon":696},{"facility":700,"status":88,"city":701,"state":49,"zip":702,"country":653,"countryCode":654,"cosmosGeoPoint":703,"geoPoint":707,"contacts":49},"IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi \u002FID# 268675","Bologna","40138",{"type":81,"coordinates":704},[705,706],11.33875,44.49381,{"lat":706,"lon":705},{"facility":709,"status":88,"city":710,"state":711,"zip":712,"country":713,"countryCode":714,"cosmosGeoPoint":715,"geoPoint":719,"contacts":49},"NHO Nagoya Medical Center \u002FID# 272515","Nagoya","Aichi-ken","460-0001","Japan","JP",{"type":81,"coordinates":716},[717,718],136.90641,35.18147,{"lat":718,"lon":717},{"facility":721,"status":88,"city":710,"state":711,"zip":722,"country":713,"countryCode":714,"cosmosGeoPoint":723,"geoPoint":725,"contacts":49},"Aichi Cancer Center \u002FID# 271978","464-8681",{"type":81,"coordinates":724},[717,718],{"lat":718,"lon":717},{"facility":727,"status":88,"city":728,"state":729,"zip":730,"country":713,"countryCode":714,"cosmosGeoPoint":731,"geoPoint":735,"contacts":49},"Hirosaki University Hospital \u002FID# 274410","Hirosaki","Aomori","036-8563",{"type":81,"coordinates":732},[733,734],140.4725,40.59306,{"lat":734,"lon":733},{"facility":737,"status":88,"city":738,"state":739,"zip":740,"country":713,"countryCode":714,"cosmosGeoPoint":741,"geoPoint":745,"contacts":49},"Yokohama Municipal Citizen's Hospital \u002FID# 271979","Yokohama","Kanagawa","221-0855",{"type":81,"coordinates":742},[743,744],139.65,35.43333,{"lat":744,"lon":743},{"facility":747,"status":88,"city":748,"state":748,"zip":749,"country":713,"countryCode":714,"cosmosGeoPoint":750,"geoPoint":754,"contacts":49},"Kyoto University Hospital \u002FID# 272312","Kyoto","606-8507",{"type":81,"coordinates":751},[752,753],135.75385,35.02107,{"lat":753,"lon":752},{"facility":756,"status":88,"city":757,"state":757,"zip":758,"country":713,"countryCode":714,"cosmosGeoPoint":759,"geoPoint":763,"contacts":49},"Niigata University Medical and Dental Hospital \u002FID# 274448","Niigata","951-8520",{"type":81,"coordinates":760},[761,762],139.04125,37.92259,{"lat":762,"lon":761},{"facility":765,"status":88,"city":766,"state":767,"zip":768,"country":713,"countryCode":714,"cosmosGeoPoint":769,"geoPoint":773,"contacts":49},"Osaka Medical And Pharmaceutical University Hospital \u002FID# 273309","Takatsuki","Osaka","569-8686",{"type":81,"coordinates":770},[771,772],135.61678,34.84833,{"lat":772,"lon":771},{"facility":775,"status":88,"city":776,"state":777,"zip":778,"country":713,"countryCode":714,"cosmosGeoPoint":49,"geoPoint":49,"contacts":49},"National Cancer Center Hospital \u002FID# 273192","Chuo-Ku","Tokyo","104-0045",{"facility":780,"status":88,"city":781,"state":777,"zip":782,"country":713,"countryCode":714,"cosmosGeoPoint":49,"geoPoint":49,"contacts":49},"The Cancer Institute Hospital Of JFCR \u002FID# 271989","Koto-ku","135-8550",{"facility":784,"status":88,"city":785,"state":49,"zip":786,"country":713,"countryCode":714,"cosmosGeoPoint":787,"geoPoint":791,"contacts":49},"Nagasaki University Hospital \u002FID# 273310","Nagasaki","852-8501",{"type":81,"coordinates":788},[789,790],129.88333,32.75,{"lat":790,"lon":789},{"facility":793,"status":88,"city":794,"state":795,"zip":796,"country":797,"countryCode":798,"cosmosGeoPoint":799,"geoPoint":803,"contacts":49},"Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie \u002FID# 273170","Lublin","Lublin Voivodeship","20-090","Poland","PL",{"type":81,"coordinates":800},[801,802],22.57009,51.25058,{"lat":802,"lon":801},{"facility":805,"status":88,"city":806,"state":807,"zip":808,"country":797,"countryCode":798,"cosmosGeoPoint":809,"geoPoint":813,"contacts":49},"Uniwersytecki Szpital Kliniczny w Bialymstoku \u002FID# 276848","Bialystok","Podlaskie Voivodeship","15-540",{"type":81,"coordinates":810},[811,812],23.16433,53.13333,{"lat":812,"lon":811},{"facility":815,"status":88,"city":816,"state":817,"zip":818,"country":797,"countryCode":798,"cosmosGeoPoint":819,"geoPoint":823,"contacts":49},"Uniwersyteckie Centrum Kliniczne \u002FID# 272418","Gdansk","Pomeranian Voivodeship","80-214",{"type":81,"coordinates":820},[821,822],18.64912,54.35227,{"lat":822,"lon":821},{"facility":825,"status":88,"city":826,"state":827,"zip":828,"country":797,"countryCode":798,"cosmosGeoPoint":829,"geoPoint":833,"contacts":49},"Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej \u002FID# 274549","Kielce","Świętokrzyskie Voivodeship","25-734",{"type":81,"coordinates":830},[831,832],20.62752,50.87033,{"lat":832,"lon":831},{"facility":835,"status":88,"city":836,"state":49,"zip":837,"country":838,"countryCode":839,"cosmosGeoPoint":840,"geoPoint":844,"contacts":49},"Pan American Center for Oncology Trials - Rio Piedras \u002FID# 268827","Rio Piedras","00935","Puerto Rico","PR",{"type":81,"coordinates":841},[842,843],-66.04989,18.39745,{"lat":843,"lon":842},{"facility":846,"status":88,"city":847,"state":848,"zip":849,"country":850,"countryCode":851,"cosmosGeoPoint":852,"geoPoint":856,"contacts":49},"Complejo Hospitalario Universitario A Coruña \u002FID# 271456","A Coruña","A Coruna","15006","Spain","ES",{"type":81,"coordinates":853},[854,855],-8.396,43.37135,{"lat":855,"lon":854},{"facility":858,"status":88,"city":859,"state":860,"zip":861,"country":850,"countryCode":851,"cosmosGeoPoint":862,"geoPoint":866,"contacts":49},"Hospital Universitario Marques de Valdecilla \u002FID# 271314","Santander","Cantabria","39008",{"type":81,"coordinates":863},[864,865],-3.80493,43.46589,{"lat":865,"lon":864},{"facility":868,"status":88,"city":869,"state":870,"zip":871,"country":850,"countryCode":851,"cosmosGeoPoint":872,"geoPoint":876,"contacts":49},"Hospital Universitario Virgen Macarena \u002FID# 271447","Seville","Sevilla","41009",{"type":81,"coordinates":873},[874,875],-5.97317,37.38283,{"lat":875,"lon":874},{"facility":878,"status":88,"city":879,"state":49,"zip":880,"country":850,"countryCode":851,"cosmosGeoPoint":881,"geoPoint":885,"contacts":49},"Hospital General Universitario de Alicante Doctor Balmis \u002FID# 271316","Alicante","03010",{"type":81,"coordinates":882},[883,884],-0.48149,38.34517,{"lat":884,"lon":883},{"facility":887,"status":88,"city":888,"state":49,"zip":889,"country":850,"countryCode":851,"cosmosGeoPoint":890,"geoPoint":894,"contacts":49},"Parc de Salut Mar - Hospital del Mar \u002FID# 271310","Barcelona","08003",{"type":81,"coordinates":891},[892,893],2.15899,41.38879,{"lat":893,"lon":892},{"facility":896,"status":88,"city":888,"state":49,"zip":897,"country":850,"countryCode":851,"cosmosGeoPoint":898,"geoPoint":900,"contacts":49},"Hospital Clinic de Barcelona \u002FID# 271452","08036",{"type":81,"coordinates":899},[892,893],{"lat":893,"lon":892},{"facility":902,"status":88,"city":888,"state":49,"zip":903,"country":850,"countryCode":851,"cosmosGeoPoint":904,"geoPoint":906,"contacts":49},"Hospital Santa Creu i Sant Pau \u002FID# 271311","08041",{"type":81,"coordinates":905},[892,893],{"lat":893,"lon":892},{"facility":908,"status":88,"city":909,"state":49,"zip":910,"country":850,"countryCode":851,"cosmosGeoPoint":911,"geoPoint":915,"contacts":49},"Hospital Universitario Virgen de la Victoria \u002FID# 271312","Málaga","29010",{"type":81,"coordinates":912},[913,914],-4.42034,36.72016,{"lat":914,"lon":913},{"facility":917,"status":88,"city":918,"state":49,"zip":919,"country":920,"countryCode":921,"cosmosGeoPoint":922,"geoPoint":926,"contacts":49},"Changhua Christian Hospital \u002FID# 280139","Changhua","500","Taiwan","TW",{"type":81,"coordinates":923},[924,925],120.5512,24.0692,{"lat":925,"lon":924},{"facility":928,"status":88,"city":929,"state":49,"zip":930,"country":920,"countryCode":921,"cosmosGeoPoint":931,"geoPoint":935,"contacts":49},"Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation \u002FID# 268789","Chiayi City","62247",{"type":81,"coordinates":932},[933,934],120.44889,23.47917,{"lat":934,"lon":933},{"facility":937,"status":88,"city":938,"state":49,"zip":939,"country":920,"countryCode":921,"cosmosGeoPoint":940,"geoPoint":944,"contacts":49},"Kaohsiung Medical University Chung-Ho Memorial Hospital \u002FID# 268139","Kaohsiung City","807",{"type":81,"coordinates":941},[942,943],120.31333,22.61626,{"lat":943,"lon":942},{"facility":946,"status":88,"city":938,"state":49,"zip":947,"country":920,"countryCode":921,"cosmosGeoPoint":948,"geoPoint":950,"contacts":49},"Kaohsiung Chang Gung Memorial Hospital \u002FID# 268138","833",{"type":81,"coordinates":949},[942,943],{"lat":943,"lon":942},{"facility":952,"status":88,"city":953,"state":49,"zip":954,"country":920,"countryCode":921,"cosmosGeoPoint":955,"geoPoint":959,"contacts":49},"National Taiwan University Cancer Center (Ntucc) \u002FID# 271586","Taipei","106",{"type":81,"coordinates":956},[957,958],121.52639,25.05306,{"lat":958,"lon":957},{"facility":961,"status":88,"city":953,"state":49,"zip":962,"country":920,"countryCode":921,"cosmosGeoPoint":963,"geoPoint":965,"contacts":49},"Taipei Veterans General Hospital \u002FID# 268787","112",{"type":81,"coordinates":964},[957,958],{"lat":958,"lon":957},{"facility":967,"status":88,"city":953,"state":49,"zip":968,"country":920,"countryCode":921,"cosmosGeoPoint":969,"geoPoint":971,"contacts":49},"Tri-Service General Hospital \u002FID# 269211","114",{"type":81,"coordinates":970},[957,958],{"lat":958,"lon":957},{"facility":973,"status":88,"city":974,"state":49,"zip":975,"country":920,"countryCode":921,"cosmosGeoPoint":976,"geoPoint":980,"contacts":49},"Linkou Chang Gung Memorial Hospital \u002FID# 268137","Taoyuan City","333",{"type":81,"coordinates":977},[978,979],121.29696,24.99368,{"lat":979,"lon":978},{"facility":982,"status":88,"city":983,"state":984,"zip":985,"country":986,"countryCode":49,"cosmosGeoPoint":987,"geoPoint":991,"contacts":49},"Sakarya Egitim ve Arastirma Hastanesi \u002FID# 272878","Adapazarı","Sakarya","54290","Turkey (Türkiye)",{"type":81,"coordinates":988},[989,990],30.40333,40.78056,{"lat":990,"lon":989},{"facility":993,"status":88,"city":994,"state":49,"zip":995,"country":986,"countryCode":49,"cosmosGeoPoint":996,"geoPoint":1000,"contacts":49},"Adana Medical Park Seyhan Hastanesi \u002FID# 272875","Adana","01140",{"type":81,"coordinates":997},[998,999],35.32531,36.98615,{"lat":999,"lon":998},{"facility":1002,"status":88,"city":1003,"state":49,"zip":1004,"country":986,"countryCode":49,"cosmosGeoPoint":1005,"geoPoint":1009,"contacts":49},"Ankara Universitesi Tip Fakultesi Cebeci Hastanesi \u002FID# 272873","Ankara","06620",{"type":81,"coordinates":1006},[1007,1008],32.85427,39.91987,{"lat":1008,"lon":1007},{"facility":1011,"status":88,"city":1012,"state":49,"zip":1013,"country":986,"countryCode":49,"cosmosGeoPoint":1014,"geoPoint":1018,"contacts":49},"Pamukkale Universitesi \u002FID# 272893","Denizli","20070",{"type":81,"coordinates":1015},[1016,1017],29.0875,37.77417,{"lat":1017,"lon":1016},{"facility":1020,"status":88,"city":1021,"state":49,"zip":1022,"country":986,"countryCode":49,"cosmosGeoPoint":1023,"geoPoint":1027,"contacts":49},"Necmettin Erbakan Universitesi Meram Tip Fakultesi - Eski Hastane \u002FID# 272882","Konya","42080",{"type":81,"coordinates":1024},[1025,1026],32.48464,37.87135,{"lat":1026,"lon":1025},{"facility":1029,"status":88,"city":1030,"state":49,"zip":1031,"country":986,"countryCode":49,"cosmosGeoPoint":1032,"geoPoint":1036,"contacts":49},"Ondokuz Mayis Universitesi \u002FID# 272899","Samsun","55139",{"type":81,"coordinates":1033},[1034,1035],36.3361,41.27976,{"lat":1035,"lon":1034},{"facility":1038,"status":88,"city":1039,"state":1040,"zip":1041,"country":1042,"countryCode":1043,"cosmosGeoPoint":1044,"geoPoint":1048,"contacts":49},"Leicester Royal Infirmary \u002FID# 276035","Leicester","Leicestershire","LE1 5WW","United Kingdom","UK",{"type":81,"coordinates":1045},[1046,1047],-1.13169,52.6386,{"lat":1047,"lon":1046},{"facility":1050,"status":88,"city":1051,"state":49,"zip":1052,"country":1042,"countryCode":1043,"cosmosGeoPoint":1053,"geoPoint":1057,"contacts":49},"Velindre Cancer Centre \u002FID# 271840","Cardiff","CF14 2TL",{"type":81,"coordinates":1054},[1055,1056],-3.18,51.48,{"lat":1056,"lon":1055},{"type":1059,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR","100575464",false,"NCT06772623","Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations","An Open-label Multi-Cohort Phase 1b\u002F2 Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease and No Actionable Genomic Alterations","Inclusion Criteria:\n\n* Must have histologically documented non-squamous (NSq) non small cell lung carcinoma (NSCLC) that is locally advanced or metastatic will be enrolled into the study.\n* Must have measurable disease per response evaluation criteria in solid tumors (RECIST) v1.1.\n* For Part 1, participants must have had no more than 1 systemic therapy for advanced disease including platinum-based chemotherapy or an immune checkpoint inhibitor (as monotherapy or in combination with chemotherapy), or appropriate targeted therapy for an actionable gene alteration, if applicable, for epidermal growth factor receptor (EGFR) wild-type (WT) NSq NSCLC.\n* For Part 2, participants must have no prior systemic therapy for advanced disease, no known actionable genomic alteration.\n* Must have documented programmed death ligand 1 (PD-L1) status.\n* For Part 2, participant must have evaluable c-Met immunohistochemistry (IHC) result per central testing prior to randomization.\n* Must have adequate organ function.\n\nExclusion Criteria:\n\n* Known uncontrolled metastases to the central nervous system.\n* History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any evidence of active ILD or pneumonitis on screening chest computed tomography (CT) scan.","ALL","18 Years",{"count":1069,"type":1070},252,"ESTIMATED","INTERVENTIONAL",[1073,1074],"PHASE1","PHASE2","Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide. The purpose of this study is to assess adverse events and change in disease activity when Telisotuzumab Adizutecan (ABBV-400) is given in combination with a programmed cell death receptor 1 (PD1) immune checkpoint inhibitor to adult participants to treat NSCLC.\n\nTelisotuzumab Adizutecan (ABBV-400) and budigalimab are investigational drugs being developed for the treatment of NSCLC. This study will be divided into two stages, with the first stage treating participants with several doses of telisotuzumab adizutecan in combination with budigalimab within the dose escalation regimen until the dose reached is tolerable and expected to be efficacious. In Stage 2 there will be 3 treatment groups. Two groups will receive pembrolizumab with different optimized doses of telisotuzumab adizutecan (to allow for the best dose to be studied in the future). One group will receive the standard of care (SOC) - pembrolizumab, pemetrexed, and investigator's choice of carboplatin or cisplatin, followed by pembrolizumab and pemetrexed. Approximately 252 adult participants with NSCLC will be enrolled in the study in 132 sites worldwide.\n\nIn the dose escalation stage participants will be treated with increasing intravenous (IV) doses of Telisotuzumab Adizutecan in combination with budigalimab until the dose of Telisotuzumab Adizutecan reached is tolerable and expected to be efficacious. In the dose optimization stage participants will be receive IV optimized doses of Telisotuzumab Adizutecan in combination with IV pembrolizumab, or IV SOC - pembrolizumab, pemetrexed, and investigator's choice of carboplatin or cisplatin, followed by pembrolizumab and pemetrexed. The study will run for a duration of approximately 33 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[1077],"Non Small Cell Lung Carcinoma",[1077,46,56,53,59,34,38,44,40,1079],"AndroMETa-Lung-536","2026-06-26",{"date":1082,"type":1083},"2026-06-30","ACTUAL",{"date":1085,"type":1083},"2025-03-06",{"date":1087,"type":1070},"2027-11",{"name":5,"class":6},103]