[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536933":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":116,"collaborators":25,"id":118,"slug":119,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":25,"eligibilityCriteria":124,"healthyVolunteers":120,"sex":125,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":25,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Pacira Pharmaceuticals, Inc","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EXPAREL","EXPERIMENTAL","A total of approximately 24 subjects (8 subjects per Part) will be enrolled. Subjects in this arm will receive EXPAREL",[13],"Drug: EXPAREL",{"label":15,"type":16,"description":17,"interventionNames":18},"bupivacaine","ACTIVE_COMPARATOR","A total of approximately 24 subjects (8 subjects per Part) will be enrolled. Subjects in this arm will receive bupivacaine",[19],"Drug: bupivacaine",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","A single dose of EXPAREL Injectable Product via LIA",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"A single dose of 0.25% bupivacaine via LIA",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Sarah Shaffer","CONTACT","973-451-4071","sarah.shaffer@pacira.com",[36,55,70,85,101],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Indiana University Health, Riley Hospital For Children","RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-86.15804,39.76838,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":53,"phoneExt":25,"email":54},"Stephanie Creamean","7657208423","stephac1@iu.edu",{"facility":56,"status":38,"city":57,"state":58,"zip":59,"country":42,"countryCode":43,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"St. Louis Children's Hospital (SLCH)","St Louis","Missouri","63110",{"type":45,"coordinates":61},[62,63],-90.19789,38.62727,{"lat":63,"lon":62},[66],{"name":67,"role":32,"phone":68,"phoneExt":25,"email":69},"Kyle Stumbaugh","314-747-0707","kyles@wustl.edu",{"facility":71,"status":38,"city":72,"state":73,"zip":74,"country":42,"countryCode":43,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Duke University Health System","Durham","North Carolina","27710",{"type":45,"coordinates":76},[77,78],-78.89862,35.99403,{"lat":78,"lon":77},[81],{"name":82,"role":32,"phone":83,"phoneExt":25,"email":84},"Amy Patrylick","919-681-2217","amy.petrylick@duke.edu",{"facility":86,"status":38,"city":87,"state":88,"zip":89,"country":42,"countryCode":43,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"University of Oklahoma (OU) - Medical Center - The Children's Hospital","Oklahoma City","Oklahoma","73104",{"type":45,"coordinates":91},[92,93],-97.51643,35.46756,{"lat":93,"lon":92},[96],{"name":97,"role":32,"phone":98,"phoneExt":99,"email":100},"Amir L Butt, MD, MPH","(405) 271-8001","36017","abutt@ouhsc.edu",{"facility":102,"status":38,"city":103,"state":104,"zip":105,"country":42,"countryCode":43,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"The University of Texas Health Science Center at Houston (UTHSC-H) - McGovern Medical School","Houston","Texas","77030",{"type":45,"coordinates":107},[108,109],-95.36327,29.76328,{"lat":109,"lon":108},[112],{"name":113,"role":32,"phone":114,"phoneExt":25,"email":115},"Emad Sorial","713-500-6186","Emad.M.Sorial@uth.tmc.edu",{"type":117,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100536933","phase-1-study-to-evaluate-the-pharmacokinetics-and-safety-of-exparel-for-postoperative-analgesia-in-subjects-undergoing-cardiac-surgery-100536933",false,"NCT06271265","Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery","A Multicenter, Open-label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 Years Undergoing Cardiac Surgery","Inclusion Criteria:\n\nAll of the following inclusion criteria must be met for eligibility:\n\n1. Pediatric participants with congenital heart defects planned to undergo cardiac surgery with cardiopulmonary bypass\n2. Male or female participants from 0 to less than 6 years of age on the day of surgery: 2 years to less than 6 years of age for Part 1; 6 months to less than 2 years of age for Part 2; 0 to less than 6 months of age for Part 3\n3. American Society of Anesthesiologists (ASA) Classes 1 through 4.\n4. Parent\u002Fguardian is able to speak, read, and understand the language of the ICF and provide informed consent for the participant.\n5. Parent\u002Fguardian is able to adhere to the study visit schedule and complete all study assessments for the participant.\n\nExclusion Criteria:\n\nExclusion Criteria:\n\nA participant will not be eligible for the study if any of the following exclusion criteria are met:\n\n1. History of hypersensitivity or idiosyncratic reactions or contradictions to EXPAREL, bupivacaine HCl, or other amide-type local anesthetics or to opioid medications\n2. Administration of EXPAREL or bupivacaine HCl within 30 days prior to IP administration\n3. Administration of an IP within 30 days or 5 elimination half-lives of such IP, whichever is longer, prior to IP administration, or planned administration of another IP or procedure during participation in this study\n4. History of preterm birth (before 35 weeks of pregnancy)\n5. History of coagulopathies or immunodeficiency disorders\n6. Disease or condition that, in the opinion of the Investigator, indicates an increased vulnerability to IPs and\u002For procedures\n7. Recent or potential exposure to COVID-19\n8. Cardiac surgery has been canceled and cannot be rescheduled within 30 days of signing the ICF because of any reason.\n9. Necessity in delayed wound closure\n10. Informed consent withdrawn before randomization","ALL","0 Years","6 Years",{"count":129,"type":130},48,"ESTIMATED","INTERVENTIONAL",[133],"PHASE1","This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 to less than 6 years of age undergoing cardiac surgery, utilizing local infiltration analgesia (LIA).",[136],"Postoperative Pain",[138,139,140],"Analgesia","Cardiac Surgery","Pediatric","2025-12-19",{"date":143,"type":144},"2025-12-29","ACTUAL",{"date":146,"type":144},"2024-03-29",{"date":148,"type":130},"2027-01",{"name":5,"class":6},5]