[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100407137":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":45,"responsibleParty":105,"collaborators":26,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":26,"eligibilityCriteria":113,"healthyVolunteers":109,"sex":114,"minAge":115,"maxAge":26,"enrollmentInfo":116,"targetDuration":26,"studyType":119,"phases":120,"briefSummary":123,"conditions":124,"keywords":26,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Ellipses Pharma","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Module 1 EP0042","EXPERIMENTAL","Establishing the safety of EP0042 as a monotherapy and establishing an appropriate dose to take forward into subsequent modules.",[13],"Drug: EP0042",{"label":15,"type":10,"description":16,"interventionNames":17},"Module 2 EP0042","* Part A: To evaluate the safety, tolerability, of EP0042 + a Bcl-2 inhibitor (venetoclax) in patients with R\u002FR FLT3 wildtype (WT) AML.\n* Part B: To evaluate the safety, tolerability, of EP0042 in combination with a Bcl 2 inhibitor (venetoclax) + a hypomethylating agent (azacitidine) in patients with R\u002FR FLT3 WT or newly diagnosed AML.",[13,18,19],"Drug: Venetoclax","Drug: Azacitidine (AZA)",[21,27,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","EP0042","EP0042 Oral 20 mg 50 mg capsules",[9,15],null,{"type":22,"name":28,"description":28,"armGroupLabels":29,"otherNames":26},"Venetoclax",[15],{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":26},"Azacitidine (AZA)","Azacitidine",[15],[35],{"name":36,"affiliation":37,"role":38},"David Taussig","The Royal Marsden, UK","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Clinical Trials Team","CONTACT","+44 20 3743 0992","Enquiries@ellipses.life",[46,60,71,80,90,96],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":26},"Royal Perth Hospital","RECRUITING","Perth","Western Australia","6000","Australia","AU",{"type":55,"coordinates":56},"Point",[57,58],115.8614,-31.95224,{"lat":58,"lon":57},{"facility":61,"status":48,"city":62,"state":26,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":70,"contacts":26},"Amsterdam UMC","Amsterdam","1081HV Amsterdam","Netherlands","NL",{"type":55,"coordinates":67},[68,69],4.88969,52.37403,{"lat":69,"lon":68},{"facility":72,"status":48,"city":73,"state":26,"zip":74,"country":64,"countryCode":65,"cosmosGeoPoint":75,"geoPoint":79,"contacts":26},"Erasmus MC","Rotterdam","3000 CA Rotterdam",{"type":55,"coordinates":76},[77,78],4.47917,51.9225,{"lat":78,"lon":77},{"facility":81,"status":48,"city":82,"state":83,"zip":26,"country":84,"countryCode":83,"cosmosGeoPoint":85,"geoPoint":89,"contacts":26},"The Royal Marsden","London","UK","United Kingdom",{"type":55,"coordinates":86},[87,88],-0.12574,51.50853,{"lat":88,"lon":87},{"facility":91,"status":48,"city":82,"state":26,"zip":92,"country":84,"countryCode":83,"cosmosGeoPoint":93,"geoPoint":95,"contacts":26},"University College London Hospital","W1T 7HA",{"type":55,"coordinates":94},[87,88],{"lat":88,"lon":87},{"facility":97,"status":48,"city":98,"state":26,"zip":99,"country":84,"countryCode":83,"cosmosGeoPoint":100,"geoPoint":104,"contacts":26},"The Christie Hospital","Manchester","M204BX",{"type":55,"coordinates":101},[102,103],-2.23743,53.48095,{"lat":103,"lon":102},{"type":106,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100407137","phase-1-study-to-evaluate-the-safety-and-tolerability-of-ep0042-100407137",false,"NCT04581512","Study to Evaluate the Safety and Tolerability of EP0042","A Modular, Multipart, Multi-arm, Open-label, Phase I\u002FIIa Study to Evaluate the Safety and Tolerability of EP0042 Alone and in Combination With Anti-cancer Treatments in Patients With Advanced Malignancies","General\n\n1. Male or female patients aged ≥ 18 years of age, at the time of informed consent, with histological or cytological confirmation of AML\n2. Ability to understand and provide written informed consent before any study-specific procedures, sampling, or analyses, including access to archival tumor tissue\n3. Ability to swallow and retain oral medication\n4. Sufficient life expectancy to allow the patient to complete at least 1 cycle (28 days) of the treatment period.\n5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2 at screening\n6. In the opinion of the investigator, all other relevant medical conditions must be well-managed and stable for at least 28 days prior to first administration of study drug\n7. Patients with pathologically confirmed\u002Fdocumented AML or MDS, as defined by the 2022 European LeukaemiaNet (ELN) recommendations, or CMML, as defined by World Health Organization (WHO) criteria, who have relapsed from or are refractory to previous therapy and have failed all (or are not eligible for\u002Fintolerant to) available approved therapies for their disease.\n8. Patients with relapsed\u002Frefractory FLT3 WT AML.\n9. Previous exposure to venetoclax, hypomethylating agent and\u002For FLT3 inhibitors (gilteritinib, midostaurin, quizartinib, sorafenib) is allowed for relapsed\u002Frefractory AML patients.\n10. Mutation status of patients must be known at trial entry.\n11. Female patients should either be of non-child-bearing potential or must agree to use highly effective methods of contraception from Screening until 6 months following administration of the last dose of study drug\n12. Male patients must use double barrier contraception from enrolment through treatment and for 6 months following administration of the last dose of study drug\n\n5.2 Core Exclusion Criteria\n\nPatients with any of the following will not be included in the study:\n\nDisease Under Study and Prior Anticancer Treatment\n\n1. Suspected brain and\u002For leptomeningeal metastases that are symptomatic or untreated or that require current therapy\n2. Acute promyelocytic leukemia (FAB:M3)\n3. Systemic anti-cancer therapy for the disease under study within 2 weeks of the first dose of study treatment. If the previous anti-cancer therapy has a very long half-life and may interact with EP0042, e.g. a strong CYP3A4 inhibitor, the washout period may need to be increased for safety reasons but will be no longer than 3 weeks (Concomitant hydroxyurea is acceptable and will be permitted throughout the screening period and during first 6 cycles of study treatment)\n4. Ongoing toxic manifestations of previous treatments that have not reduced to at least CTCAE Grade 1. Exceptions to this are alopecia or certain Grade 2 treatment related toxicities, which in the opinion of the Investigator should not exclude the patient.\n5. Transplantation (allogeneic or autologous) within last 90 days, or on active immunosuppressive therapy for graft versus host disease in last 2 weeks\n\n   Laboratory Parameters\n6. Patient with any out-of-range laboratory values defined as shown below.\n\n   • Creatinine clearance (calculated using Cockcroft-Gault formula, or measured) \\\u003C 50 mL\u002F min\n7. Inadequate liver function as demonstrated by\n\n   * total serum bilirubin ≥ 1.5 times the upper limits of normal range (ULN) or\n   * ALT ≥3 times the ULN or\n   * AST ≥3 times the ULN or\n   * AST or ALT ≥5 times the ULN in the presence of liver involvement by leukemia","ALL","18 Years",{"count":117,"type":118},70,"ESTIMATED","INTERVENTIONAL",[121,122],"PHASE1","PHASE2","A research study looking at a new treatment for patients with advanced cancer, to investigate different doses of the experimental study drug, EP0042, in order to determine a dose, which is safe, well-tolerated and likely to be effective in treating AML (acute myeloid leukaemia).",[125,126,127],"Acute Myeloid Leukemia","Chronic Myelomonocytic Leukemia","Myelodysplastic Syndromes","2026-06-18",{"date":130,"type":131},"2026-06-22","ACTUAL",{"date":133,"type":131},"2020-11-02",{"date":135,"type":118},"2027-12",{"name":5,"class":6},6]