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brainstem, meningeal, or spinal cord metastases or compression\n* Active autoimmune diseases requiring systemic treatment within the past 2 years\n* Participation in another investigational study within 30 days or 5 half-lives of the investigational product.\n* Pregnant or breastfeeding individuals.\n* Inability or unwillingness to comply with study requirements.\n* Study staff or their immediate family members directly involved in the conduct of the study.","ALL","18 Years",{"count":484,"type":485},132,"ESTIMATED","INTERVENTIONAL",[488,489],"PHASE1","PHASE2","This study is being done to learn more about a new medicine called PF-08634404. 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The study will also look at how the medicine may change certain markers in the body that are linked to cancer.\n\nTo join the study, participants must:\n\n* Be adults (18 years or older) and\n* Have locally advanced or metastatic urothelial cancer,\n\nThe study has two groups:\n\n* Cohort A: People who have already received treatment for their cancer will get the study medicine ( PF-08634404) alone.\n* Cohort B: People who have not had treatment before will get the study medicine along with another cancer medicine called enfortumab vedotin.\n\nEveryone in the study will get the study medicine through a vein (IV infusion) with or without enfortumab vedotin. Treatment will continue as long as it helps and side effects are manageable.\n\nBefore starting, participants will go through a screening period to check if they are eligible. During the study, they will have regular visits for treatment, health checks, and tests to see how the cancer is responding. 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