[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644455":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hyaluronic acid mouthwah","EXPERIMENTAL","Participants in the experimental group will use a hyaluronic acid mouthwash (Q-Afta®, CIRA Pharma, Egypt). The principle investigator will instruct each participant to rinse with 10 mL of the mouthwash for 30-60 seconds twice daily after toothbrushing for a period of 14 days. And also not to swallow the mouthwash and to avoid eating or drinking for 30 minutes after rinsing",[13],"Drug: Hyaluronic Acid mouthwash",{"label":15,"type":16,"description":17,"interventionNames":18},"Chlorohexidine mouthwash","ACTIVE_COMPARATOR","Participants in the control group will use a chlorohexidine mouthwash (Hexitol). The principle investigator will instruct each participant to rinse with 10 mL of the mouthwash for 30-60 seconds twice daily after toothbrushing for a period of 14 day and not to swallow the mouthwash and to avoid eating or drinking for 30 minutes after rinsing.",[19],"Drug: Chlorohexidine 0.12% mouthwash",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Hyaluronic Acid mouthwash","Q-Afta®, CIRA Pharma, Egypt",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Chlorohexidine 0.12% mouthwash","Hexitol®, 0.12% chlorhexidine gluconate; Arab Drug Company",[15],[32],{"name":33,"affiliation":5,"role":34},"Ola M Omar, Professor","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Yasmeen AS Abdelqader, Bachelors","CONTACT","+201018727929","Yasmeen.saleh@dentistry.cu.edu.eg",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":45,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":26},"Faculty of dentistry, Cairo university","Cairo","Egypt","11411","EG",{"type":49,"coordinates":50},"Point",[51,52],31.24967,30.06263,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Yasmeen Abdullah Saleh Abdelqader","Principal investigator","100644455","phase-1-taste-acceptance-and-effectiveness-of-hyaluronic-acid-and-chlorhexidine-mouthwashes-in-children-with-gingivitis-100644455",false,"NCT07662226","Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis","Taste Acceptance and Clinical Effectiveness of Hyaluronic Acid Versus Chlorhexidine Mouthwashes in Children With Plaque-Induced Gingivitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged from 8-12 years of both sexes.\n* Children with a history of bleeding on brushing typical signs and symptoms of gingivitis.\n* Healthy child (ASA I).\n* Eruption of upper and lower permanent central and lateral incisors.\n* Parent's agreement to sign the informed consent.\n* Parent's ability for attending follow up visits.\n\nExclusion Criteria:\n\n* Children -allergic to Chlorhexidine or Hyaluronic acid.\n* Children with special health care needs or having a history of serious systemic disease that may affect the gingival health.\n* Use of Systemic NSAIDs, steroids, or antibiotics within a month before the study.\n* Children undergoing orthodontic treatment or having an intra-oral prosthesis.",true,"ALL","8 Years","10 Years",{"count":70,"type":71},32,"ESTIMATED","INTERVENTIONAL",[74],"PHASE1","This randomized controlled clinical trial aims to compare the taste acceptance and clinical effectiveness of hyaluronic mouthwash and chlorhexidine mouthwash in children with plaque-induced gingivitis. Clinical outcomes will be assessed using gingival and plaque indices, while taste acceptance will be evaluated using a validated hedonic scale. The findings may help identify a mouthwash that is both effective and acceptable to children, thereby improving adherence to oral hygiene practices.",[77],"Plaque Induced Gingival Disease",[79,80,81,82,83,84,85],"gingivitis","Chlorohexidine","Hyaluronic acid","Mouthwashe","Children","Taste acceptance","Palatability","NOT_YET_RECRUITING","2026-06-18",{"date":89,"type":90},"2026-06-23","ACTUAL",{"date":92,"type":71},"2026-08-01",{"date":94,"type":71},"2027-05-01",{"name":5,"class":6},1]