[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420907":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":64,"collaborators":32,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":32,"studyType":82,"phases":83,"briefSummary":86,"conditions":87,"keywords":32,"overallStatus":89,"whyStopped":32,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Iowa","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Control Arm","PLACEBO_COMPARATOR","Participants in this arm will receive placebo during the trial for 15 weeks, the placebo will follow the same schedule as the Terazosin group; the placebo capsules will have the same appearance as the Terazosin capsules.",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Terazosin Arm","EXPERIMENTAL","Participants in this arm will receive Terazosin during the trial for 15 weeks. Participants will start at 1mg daily for the first 6 week, then the dosage will be increased to 5mg daily over 3 weeks, and continued for the last 6 weeks.",[19],"Drug: Terazosin Hydrochloride",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Terazosin Hydrochloride","In this double blind, randomized, placebo controlled phase I clinical trial, subjects randomized into the Terazosin group will receive Terazosin hydrochloride treatment for 15 weeks. Participants will start at 1mg daily for the first 6 week, then the dosage will be increased to 5mg daily over 3 weeks, and continued for the last 6 weeks.",[15],[27],"Terazosin, Hytrin",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","In this double blind, randomized, placebo controlled phase I clinical trial, subjects randomized into the control group will receive placebo for 15 weeks.",[9],null,[34],{"name":35,"affiliation":5,"role":36},"Nandakumar Narayanan, MD, PhD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"qiang zhang, MD","CONTACT","4154251369","qiang-zhang@uiowa.edu",{"name":44,"role":40,"phone":32,"phoneExt":32,"email":45},"Jordan Schultz, Pharm D","jordan-schultz@uiowa.edu",[47],{"facility":5,"status":32,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Iowa City","Iowa","52252","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-91.53017,41.66113,{"lat":57,"lon":56},[60,61,63],{"name":39,"role":40,"phone":32,"phoneExt":32,"email":42},{"name":62,"role":40,"phone":32,"phoneExt":32,"email":45},"Jordan Schultz, PharmD",{"name":35,"role":36,"phone":32,"phoneExt":32,"email":32},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"SPONSOR_INVESTIGATOR","Qiang Zhang","Associate of Neurology","100420907","phase-1-terazosin-for-dementia-with-lewy-bodies-100420907",false,"NCT04760860","Terazosin for Dementia With Lewy Bodies","a Randomized, Double Blind, Placebo Controlled Clinical Trial Exploring the Target Engagement and Tolerability of Terazosin Hydrochloride in Patients With Dementia With Lewy Bodies","TZ-DLB","Inclusion Criteria:\n\n* Men or women with the diagnosis of dementia with Lewy Bodies per 2017 DLB Consortium criteria.\n* Baseline MOCA 18 or above. On stable AChEI and\u002For memantine treatment regimen for ≥4 weeks prior to baseline.\n\nExclusion Criteria:\n\n* Subjects unwilling or unable to give informed consent\n* No confounding acute or unstable medical, psychiatric, orthopedic condition. Subjects who have hypertension, diabetes mellitus, depression, or other common age-related illness will be included if their disease under control with stable treatment regimen for at least 30 days.\n* Orthostatic hypotension defined as symptomatic decrease in BP \\> 20mmHg systolic or \\> 10mmHg diastolic on supine to sitting or standing, or a sitting blood pressure of ≤90\u002F60.\n* Clinically significant traumatic brain injury or post-traumatic stress disorder\n* Presence of other known medical comorbidities that in the investigator's opinion would compromise participation in the study\n* Psychiatric comorbidities including major depression, bipolar affective disorder, or other mental health disorders that are sufficiently severe to increase adverse event risk or impact neurology assessment in the opinion of the responsible site principal investigator. Subjects with clinically significant depression as determined by a Beck Depression Inventory score greater than 21 at the screening visit. Current suicidal ideation within one year prior to the baseline visit as evidenced by answering \"yes\" to Questions 4 or 5 on the suicidal ideation portion of the Columbia-Suicide Severity Rating Scale (C-SSRS) If the participant has a Beck Anxiety Score greater than 22 at the initial screening visit.\n* Use of investigational drugs within 30 days before screening\n* Subjects have to be on a stable regimen of central nervous system acting medications (benzodiazepines, antidepressants, hypnotics) for 30 days prior to the baseline visit\n* Use of doxazosin, alfuzosin, prazosin, or tamsulosin\n* For female participant, pregnancy, or plans for child-bearing during study period\n* Participant is restricted from traveling to and from the study site","ALL","0 Years","90 Years",{"count":80,"type":81},40,"ESTIMATED","INTERVENTIONAL",[84,85],"PHASE1","PHASE2","The TZ-DLB trial will be a 3:2 (active:placebo) randomized, double-blind, placebo-controlled Pilot trial to evaluate the tolerability of terazosin for the treatment of dementia with Lewy bodies.",[88],"Dementia With Lewy Bodies","NOT_YET_RECRUITING","2026-03-10",{"date":92,"type":93},"2026-03-12","ACTUAL",{"date":95,"type":81},"2027-10",{"date":97,"type":81},"2030-12",{"name":66,"class":6},1]