[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100304218":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":51,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":20,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":36,"whyStopped":20,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Guangzhou 8th People's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CAR-T therapy","EXPERIMENTAL","Transfusing CAR-T cells at least 1 million clone every time (once or twice) based on cART after attaining plasma HIV suppression (plasma HIV RNA \\\u003C50 cp\u002Fml) and CD4+ cell count more than 350 cells\u002Ful over 1 year by cART without active HCV or HBV infection or opportunistic infections. If the candidates reach the criteria of discontinuing cART, they will stop cART and receive close observation. Once the plasma HIV viral load rebound to over 1000 cp\u002Fml, they will restart cART immediately.",[13],"Biological: CAR-T cells",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","CAR-T cells","HIV-1 specific chimeric antigen receptor cells",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Cai Weiping, Bachelor","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Li Linghua, Doctor","CONTACT","020-83710825","llheliza@126.com",{"name":23,"role":28,"phone":32,"phoneExt":20,"email":33},"020-83710816","gz8hcwp@126.com",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Guangzhou","Guangdong","510060","China","CN",{"type":43,"coordinates":44},"Point",[45,46],113.25,23.11667,{"lat":46,"lon":45},[49],{"name":50,"role":28,"phone":29,"phoneExt":20,"email":30},"Linghua LI, doctor",{"type":24,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Linghua LI","Vice Chief physician",[55],{"name":56,"class":6},"Sun Yat-sen University","100304218","phase-1-the-effect-of-chimeric-antigen-receptor-car-t-cell-therapy-on-the-reconstitution-of-hiv-specific-immune-function-100304218",false,"NCT03240328","The Effect of Chimeric Antigen Receptor (CAR)-T Cell Therapy on the Reconstitution of HIV-specific Immune Function","The Effect of CAR-T Cell Therapy on the Reconstitution of HIV-specific Immune Function","Inclusion Criteria:\n\n1. HIV infection confirmed.\n2. Receiving cART more than 12 months.\n3. HIV viral-load \\\u003C 50 copies\u002Fml and CD4 cell count more than 350 cells\u002Ful.\n4. Without serious liver, heart, liver and kidney diseases.\n5. The subjects know about the study and volunteer to attend the research and sign the informed consent.\n\nExclusion Criteria:\n\n1. With active HBV or HCV infection, or serious opportunistic infections.\n2. With serious chronic disease such like diabetes, the mental illness,et al\n3. History of suffering from pancreatitis during cART.\n4. Pregnant or breast-fed.\n5. With poor adherence.\n6. Unable to complete follow up.","ALL","18 Years","60 Years",{"count":68,"type":69},40,"ESTIMATED","INTERVENTIONAL",[72],"PHASE1","To study the safety and effectiveness of CAR-T Cell therapy on HIV patients whose plasma HIV has been successfully suppressed after cART, which is expected to enhance the res-constitution of HIV-specific immune function to assist the eradication of HIV reservoir.",[75],"HIV\u002FAIDS",[77,78,79],"CAR-T HIV therapy","immunotherapy","function cure","2022-09-13",{"date":82,"type":83},"2022-09-14","ACTUAL",{"date":85,"type":83},"2017-10-04",{"date":87,"type":69},"2030-12-31",{"name":5,"class":6},1]