[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580354":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":69,"collaborators":25,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":25,"enrollmentInfo":82,"targetDuration":25,"studyType":85,"phases":86,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Abu Dhabi Health Services Company","OTHER_GOV",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"Treatment A: 30g powdered GA in 100ml water, consumed daily","EXPERIMENTAL",[12],"Dietary Supplement: Gum Arabic",{"label":14,"type":15,"description":16,"interventionNames":17},"Treatment B: 100ml water, consumed daily.","OTHER","Treatment B: 100ml water, consumed daily. Participants will follow their usual medications and lifestyle, randomized into two sequences (AB or BA).",[18],"Other: Water",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Gum Arabic","Gum Arabic (Acacia seyal and Acacia senegal) 30g powdered GA in 100ml water, consumed daily.",[9],null,{"type":15,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Water","100ml water, consumed daily",[14],[31],{"name":32,"affiliation":33,"role":34},"Stephen G Holt, MD","Abu Dhabi Health Services Co. -SEHA","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+971 2 711 7444","sholt@seha.ae",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Edward R Smith, PhD","esmith@seha.ae",[44],{"facility":45,"status":46,"city":47,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"SEHA Kidney Care (SKC)","RECRUITING","Abu Dhabi","United Arab Emirates","AE",{"type":51,"coordinates":52},"Point",[53,54],54.39696,24.45118,{"lat":54,"lon":53},[57,61,65,67],{"name":58,"role":37,"phone":59,"phoneExt":25,"email":60},"Ayman I Allaham, MS","+971 2 711 7472","aibrahim@seha.ae",{"name":62,"role":37,"phone":25,"phoneExt":63,"email":64},"Alina Naeem, MBBS","+971 2 4102534","alnaeem@seha.ae",{"name":41,"role":66,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":68,"role":34,"phone":25,"phoneExt":25,"email":25},"Stephen G Holt, MD PhD",{"type":34,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Stephen Geoffrey Holt","SEHA Kidney Care (SKC) Professor Director","100580354","phase-1-the-effect-of-gum-arabic-ga-on-residual-renal-function-in-adult-dialysis-patients-in-abu-dhabi-100580354",false,"NCT06836206","The Effect of Gum Arabic (GA) on Residual Renal Function in Adult Dialysis Patients in Abu Dhabi","The Effect of Gum Arabic (GA) on Adult Dialysis Patients in Abu Dhabi: A Prospective Randomized-controlled Trial (The GADAD Study)","GAESRD","Inclusion Criteria:\n\nTo be eligible to participate in this trial, an individual must meet all the following criteria:\n\n1. Men and women ≥18 years of age with diagnosed ESRD and prescribed regular dialysis at least once a week, weekly at least for past two weeks.\n2. For past two weeks including women of childbearing potential who are currently adopting any method of contraception or have completed the family and undergone sterilization procedures and women of non-childbearing potential.\n3. Patients with residual renal function - Patients who produce a minimum of 200 ml of urine during a full day of collection (A full day collection: the patient discards the first urine sample on the day of collection then collects all urine for the entire day and night and collects the first urine sample of the next day) r on a non-dialysis long break day.\n4. Able and willing to complete the whole period of the study (maximum of 266 days from enrolment).\n5. With the ability to understand the study procedures, the informed consent \\& voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.\n\nExclusion Criteria:\n\n1. Women of childbearing potential not adopting any methods of contraception, have not undergone sterilization.\n2. Women Pregnant or lactating\n3. Patients who plan to conceive (or for their partners to conceive) within 12 months of randomization.\n4. Patient presenting with serum K+levels ≥ 6mmol\u002FL based on the last two reports as per medical records.\n5. Patients who produce less than 200 ml of urine during 24 hours urine collection at baseline assessment.\n6. Peritoneal dialysis.\n7. Kidney transplant or booked for a live transplant within 259 days of randomization.\n8. Patients gaining \\>4 kg between dialysis sessions in the past 2 weeks.\n9. People with known allergies to quillaja bark or similar tree bark.\n10. Patients are already participating in another clinical trial (excluding COVID-19 vaccine or COVID-19 drug trials).\n11. Patients on immunosuppression for kidney transplant.\n\nAdditional exclusion criteria for follow-up visits.\n\n1. Patient informs of pregnancy.\n2. Severe adverse reaction to the interventional product.","ALL","18 Years",{"count":83,"type":84},40,"ESTIMATED","INTERVENTIONAL",[87,88],"PHASE1","PHASE2","Gum Arabic (GA), derived from Acacia trees, has shown potential benefits in metabolic, renal, and inflammatory conditions. This study explores the impact of GA on residual renal function in end-stage renal disease (ESRD) patients undergoing dialysis, as current evidence is limited.",[91],"End Stage Renal Disease (ESRD)",[22,93,94],"ESRD","Acacia seyal and Acacia senegal","2025-02-14",{"date":97,"type":98},"2025-02-20","ACTUAL",{"date":100,"type":98},"2025-02-03",{"date":102,"type":84},"2026-04-30",{"name":5,"class":6},1]