[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574801":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":29,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":29,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":29,"studyType":74,"phases":75,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":83,"whyStopped":29,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"TC Erciyes University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Stem cell group","EXPERIMENTAL","Human umbilical cord stem cells will be used.",[13],"Genetic: Stem Cell Product",{"label":15,"type":10,"description":16,"interventionNames":17},"Exosome group","Exosomes obtained from umbilical cord stem cells will be used.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Bleeding group","A clot will be formed by bleeding in the periapical region of the root canals.",[22],"Biological: Bleeding and clots",[24,30],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"GENETIC","Stem Cell Product","Human umbilical cord stem cells and exosomes will be used.",[15,9],null,{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":29},"BIOLOGICAL","Bleeding and clots","Exosomes obtained from human umbilical cord stem cells will be used",[19],[36],{"name":37,"role":38,"phone":39,"phoneExt":29,"email":40},"İpek ERASLAN AKYÜZ","CONTACT","+9 5385591409","ipekemamak@hotmail.com",[42],{"facility":43,"status":29,"city":44,"state":45,"zip":29,"country":46,"countryCode":29,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Erciyes University","Melikgazi","Kayseri","Turkey (Türkiye)",{"type":48,"coordinates":49},"Point",[50,51],36.21708,38.72455,{"lat":51,"lon":50},[54],{"name":29,"role":38,"phone":55,"phoneExt":29,"email":56},"+9 352 438 06 57","dent@erciyes.edu.tr",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Ipek Eraslan Akyuz","Dentist","100574801","phase-1-the-effect-of-human-umbilical-cord-mesenchymal-stem-cells-and-exosomes-on-the-healing-of-postoperative-pain-and-periapical-lesions-in-the-treatment-of-apical-periodontitis-randomized-controlled-clinical-study-100574801",false,"NCT06764004","The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study","Inclusion Criteria:\n\n1. Molar teeth with open apex\n2. Teeth with apical periodontitis\n3. Teeth for which prosthetic restoration is not planned\n4. Patients between the ages of 9-15 without any significant health problems\n5. Patients who are not accompanied by periodontal problems and whose oral hygiene is in good condition\n\nExclusion Criteria:\n\n1. Individuals with systemic diseases and allergic reactions\n2. Severely damaged teeth\n3. Previous root canal treatment has been performed on the tooth.\n4. Use of antibiotics, anti-inflammatory, and painkillers in the last two weeks\n5. Teeth with cracks and broken lines",true,"ALL","9 Years","15 Years",{"count":72,"type":73},45,"ESTIMATED","INTERVENTIONAL",[76,77],"PHASE1","PHASE2","The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic treatment of necrotic open apex molar teeth.\n\nRegenerative endodontic treatment aims to disinfect root canals and revascularize pulp tissue. Our goals in this study are; obtaining umbilical cord-derived MSCs, obtaining exosomes derived from umbilical cord MSCs, selecting patients with molar teeth with necrotic open apex and periapical lesion, initiation of regenerative endodontic treatment and disinfection of root canals, induction of bleeding in the periapical region and formation of a blood clot in the root canal in the 1st patient group, in the 2nd patient group, umbilical cord-derived MSCs were placed in the root canals without bleeding in the periapical region, in the 3rd patient group, placement of exosomes from umbilical cord-derived MSCs into the root canals without causing bleeding in the periapical region, it is the follow-up of patients at regular intervals for up to 1 year after treatment is completed.",[80],"Apical Periodontitis",[82],"Regenerative endodontics, rejeneration, stem cell","NOT_YET_RECRUITING","2025-01-07",{"date":86,"type":87},"2025-01-08","ACTUAL",{"date":89,"type":73},"2025-01-01",{"date":91,"type":73},"2025-05-01",{"name":5,"class":6},1]