[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100433886":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":32,"locations":33,"responsibleParty":61,"collaborators":32,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":32,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":32,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":32,"overallStatus":35,"whyStopped":32,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MFAT (Micro Fragmented Adipose Tissue)","EXPERIMENTAL","Intra-articular shoulder injection of autologous Micro Fragmented Adipose Tissue harvested from the thigh using tumescent lipoaspiration and processing with minimal manipulation. This harvested tissue will then be injected into the patient's shoulder.",[13],"Biological: Micro Fragmented Adipose Tissue",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Therapy","ACTIVE_COMPARATOR","Intra-articular injection of corticosteroid (Triamcinolone 40mg)",[19],"Biological: Corticosteroid injection",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Micro Fragmented Adipose Tissue","Harvesting of Micro Fragmented Adipose Tissue with intra-articular injection",[9],[27],"MFAT",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Corticosteroid injection","Sham harvesting of adipose tissue without intra-articular injection. Intra-articular injection of corticosteroid.",[15],null,[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Stanford","California","94305","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-122.16608,37.42411,{"lat":45,"lon":44},[48,53,56,59],{"name":49,"role":50,"phone":51,"phoneExt":32,"email":52},"Jessica Nguyen, BS","CONTACT","(650)723-0003","jessn16@stanford.edu",{"name":54,"role":50,"phone":51,"phoneExt":32,"email":55},"Elizabeth(Telsie) Jameiro, MD","ejameiro@stanford.edu",{"name":57,"role":58,"phone":32,"phoneExt":32,"email":32},"Eugene Y Roh, MD","PRINCIPAL_INVESTIGATOR",{"name":60,"role":58,"phone":32,"phoneExt":32,"email":32},"Geoffrey D Abrams, MD",{"type":58,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Eugene Roh","Clinical Associate Professor","100433886","phase-1-the-effect-of-micro-fragmented-adipose-tissue-mfat-on-shoulder-osteoarthritis-100433886",false,"NCT04929951","The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis","Inclusion Criteria:\n\n* Age between 25 and 75 years-old\n* Diagnosis of pre-existing osteoarthritis of the glenohumeral joint\n* Working understanding of the English language and able to fully understand the procedure\n* Capable of providing informed consent\n* Able to complete online, in-person or phone surveys for the purposes of follow-up\n* Capable of understanding pre- and post-procedure care instructions\n* Ambulatory at baseline\n* Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy and trial of anti-inflammatory medications if not contraindicated, with or without concomitant bracing and\u002For injections.\n\nExclusion Criteria:\n\n* Age \\\u003C 25 or \\> 75 years old\n* Radiographs demonstrating either no, little osteoarthritis, severe(bone on bone) osteoarthritis\n* Prior total or partial joint replacement surgery or surgery involving cartilage regeneration\n* Previous cortisone, PRP or Hyaluronic acid intra-articular injection within the last 3 months\n* Co-morbidity with the rheumatologic condition, inflammatory arthritis\n* Currently undergoing immunomodulatory therapy\n* Uncontrolled endocrine disorder\n* BMI \\>40 or joint space not visible by ultrasound\n* Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and\u002For hepatitis C (HCV), infection, and poorly controlled diabetes (HgA1C \\>7.0)\n* Pregnancy or planned pregnancy\n* previous stem cell injection into treatment joint\n* Patient scheduled to undergo any concomitant shoulder surgical procedures or other surgery which may affect outcomes.\n* Coagulopathy or anticoagulant treatment\n* Chronic pain involving multiple body parts or opioid medication management\n* Diagnosis of fibromyalgia\n* Concomitant massive(2 tendons with retraction), complete rotator cuff tendon tear","ALL","25 Years","75 Years",{"count":74,"type":75},48,"ESTIMATED","INTERVENTIONAL",[78],"PHASE1","This is a non-surgical trial comparing the clinical and functional outcomes of patients with osteoarthritis treated with Intra-articular injection of Micro Fragmented Adipose Tissue versus conventional therapy of intra-articular injection of corticosteroid.",[81,82],"Osteoarthritis Shoulder","Shoulder Pain","2025-10-28",{"date":85,"type":86},"2025-10-30","ACTUAL",{"date":88,"type":86},"2022-07-28",{"date":90,"type":75},"2027-12-31",{"name":5,"class":6},1]