[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574057":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":12,"responsibleParty":36,"collaborators":12,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":12,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":12,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":12,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":12},{"fullName":5,"class":6},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Expectant treatment","NO_INTERVENTION","The POl patients undergo transvaginal ultrasound to observe follicular growth every 1-2 weeks, with a monitoring period of 3 months.",null,{"label":14,"type":6,"description":15,"interventionNames":16},"In vitro fertilization - Embryo transfer","Embryo vitrification and freezing were performed after fertilization of oocytes.",[17],"Drug: human chorionic gonadotropin",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","human chorionic gonadotropin","The POI patients receive a single intramuscular injection of 10,000 units of human chorionic gonadotropin.",[14],[25],"HCG",[27],{"name":28,"affiliation":29,"role":30},"Xiao Chen, Master","The Fourth Affiliated Hospital Zhejiang University School of Medicine","PRINCIPAL_INVESTIGATOR",[32],{"name":28,"role":33,"phone":34,"phoneExt":12,"email":35},"CONTACT","13868903230","30395478@qq.com",{"type":37,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100574057","phase-1-the-study-of-human-chorionic-gonadotropin-hcg-activating-the-dormant-follicles--100574057",false,"NCT06754332","The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles .","The Research on the Role of Human Chorionic Gonadotropin (HCG) Activation in Vivo on the Dormant Follicles in Patients With Premature Ovarian Insufficiency (POI).","Inclusion Criteria:\n\n1. Females under 40 years of age with amenorrhea or oligomenorrhea for at least four months, and elevated follicle-stimulating hormone (FSH) levels \\> 25 IU\u002Fl on two separate occasions (with a 4-week interval);\n2. Ultrasound (B-mode) indicating no antral follicle development in both ovaries for at least 3 months prior to study participation;\n3. Those who agree to participate in this study and voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n1. Individuals over 40 years of age, or under 40 years of age with regular menstruation, normal ovulation, amenorrhea or oligomenorrhea for less than 4 months, and elevated follicle-stimulating hormone (FSH) levels \\\u003C 25 IU\u002Fl on two or more separate occasions (with a 4-week interval);\n2. Those with contraindications to the use of injectable human chorionic gonadotropin (HCG);\n3. Those with asthma, epilepsy, heart disease, migraines, renal impairment, hypertension, or other diseases;\n4. Patients deemed by the researcher as otherwise unsuitable for participation in this study.\"","FEMALE","20 Years","39 Years",{"count":49,"type":50},60,"ESTIMATED","INTERVENTIONAL",[53],"PHASE1","This project aims to activate dormant follicles in patients with premature ovarian insufficiency by injecting human chorionic gonadotropin (hCG) to explore the feasibility of a treatment plan that stimulates the growth of dormant follicles, not visible to the naked eye, to antral follicles visible under ultrasound, without visible follicle growth. The project also seeks to enable patients to conceive offspring carrying their own genetic material through in vitro fertilization (IVF) technology.",[56],"Premature Ovarian Insufficiency",[58,25,59],"POI","dormant follicles","NOT_YET_RECRUITING","2025-03-11",{"date":63,"type":64},"2025-03-12","ACTUAL",{"date":66,"type":50},"2025-04-01",{"date":68,"type":50},"2029-08-31",{"name":5,"class":6}]