[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589359":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":58,"collaborators":25,"id":62,"slug":25,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":87,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Wayne State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active taVNS","EXPERIMENTAL","Active transcutaneous auricular vagus nerve stimulation",[13],"Device: transcutaneous auricular vagus nerve stimulation",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham taVNS","SHAM_COMPARATOR",[18],"Device: sham transcutaneous auricular vagus nerve stimulation",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","transcutaneous auricular vagus nerve stimulation","FDA-cleared Digitimer DS7A Constant Current Stimulator (Digitimer Ltd., USA) will deliver electrical stimulation for 60 mins. Active stimulation will consist of direct electrical stimulation to the inner side of the left tragus (anode on the cymba concha, cathode on the surface of the tragus), thereby stimulating the ABVN. Stimulation parameters will consist of 500μs pulse width, 25Hz frequency, delivered at 200% of each participant's individual perceptual threshold (PT) in 60sec on\u002Foff trains.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"sham transcutaneous auricular vagus nerve stimulation","FDA-cleared Digitimer DS7A Constant Current Stimulator (Digitimer Ltd., USA) will deliver electrical stimulation for 60 mins. Sham will be delivered to the ear lobe. Stimulation parameters will consist of 500μs pulse width, 25Hz frequency, delivered at 200% of each participant's individual perceptual threshold (PT) in 60sec on\u002Foff trains.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Danielle Taylor, PhD","CONTACT","313-774-3606","dtaylo@med.wayne.edu",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},"Study Coordinator","wsu.spark.study@gmail.com",[40],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Tolan Park Research Clinic, Wayne State University","Detroit","Michigan","48201","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-83.04575,42.33143,{"lat":51,"lon":50},[54],{"name":55,"role":33,"phone":56,"phoneExt":25,"email":57},"Executive Assistant Dept of Psych. & Behav. Neurosciences","(313) 577-9510","mcaton@med.wayne.edu",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Danielle Taylor","Assistant Professor","100589359",false,"NCT06953388","Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD","SPARK-VNS: Facilitating Adaptive Posttraumatic Processing With Non-Invasive Vagus Nerve Stimulation","SPARK-VNS","Inclusion Criteria:\n\n1. Ages 18-80\n2. Fluent in English\n3. Experience with a DSM-5 Criterion A trauma (LEC-5)\n4. Probable PTSD (PCL-5 ≥ 32)\n\nExclusion Criteria:\n\n1. Visual or Auditory impairment\n2. Major injury at time of screen or study procedures\n3. Taking ≥20 mg morphine per day\n4. Current substance use or intoxication (12-panel drug test)\n5. Intellectual disability (MoCA)\n6. Self-inflicted injury\n7. Occupational injury\n8. Prisoner\n9. Ongoing domestic violence\n10. Pregnant or breastfeeding\n11. Contraindications for taVNS","ALL","18 Years","80 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"PHASE1","The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle) and questionnaires. The main questions it aims to answer are:\n\nDoes non-invasive vagus nerve stimulation help reduce anxious arousal? Does non-invasive vagus nerve stimulation help dampen learned fear?",[80],"PTSD - Post Traumatic Stress Disorder",[82,83,84,85,86],"PTSD","brain stimulation","fear learning","autonomics","fear potentiated startle","NOT_YET_RECRUITING","2025-05-13",{"date":90,"type":91},"2025-05-18","ACTUAL",{"date":93,"type":74},"2026-02-01",{"date":95,"type":74},"2032-12",{"name":5,"class":6},1]