[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588141":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":34,"responsibleParty":51,"collaborators":55,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":22,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":22,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":37,"whyStopped":22,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Jordan","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Extracellular vesicles (EV)","EXPERIMENTAL","Intra-articular Extracellular vesicles injection will be given to each patient in 2 doses",[13],"Biological: Extracellular vesicles",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","Extracellular vesicles","Intra-articular extravascular vesicles injection.",[9],[21],"EV",null,[24,29],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Hanan Jafar, PhD","CONTACT","00962798871087","hanan.jafar@gmail.com",{"name":30,"role":26,"phone":31,"phoneExt":32,"email":33},"Abdallah Awidi, MD","0096265355000","23960","abdalla.awidi@gmail.com",[35],{"facility":36,"status":37,"city":38,"state":22,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Cell Therapy Center","RECRUITING","Amman","00962","Jordan","JO",{"type":43,"coordinates":44},"Point",[45,46],35.94503,31.95522,{"lat":46,"lon":45},[49,50],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},{"name":30,"role":26,"phone":31,"phoneExt":32,"email":33},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Hanan Jafar","Principal Investigator",[56,59],{"name":57,"class":58},"Abdalla Awidi Abbadi, MD","UNKNOWN",{"name":60,"class":58},"The University of Jordan","100588141","phase-1-use-of-extracellular-vesicles-ev-for-knee-osteoarthrosis-100588141",false,"NCT06937528","Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis","Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Extracellular Vesicles (EV) for Advanced Stage III and IV KOA","Inclusion Criteria:\n\n* Severe KOA stage III or IV by Laurance \\& Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint.\n* Willing to participate by signing the informed consent\n\nExclusion Criteria:\n\n* Sublaxation beyond 20 degrees of the bones of the knee joint\n* Oral anticoagulants or heparin therapy\n* Heart failure or arrhythmia\n* Body Mass Index \\> 35\n* Uncontrolled Diabetes Mellitus.\n* Evidence of Infectious Diseases.\n* Active infection\n* Malignancy\n* Pregnancy\n* Anemia less than 11g\u002Fdl or thrombocytopenia less than 100,000 or leucopenia less than 3000.\n* Unreliable patients\n* Non-resident in Jordan","ALL","42 Years","75 Years",{"count":72,"type":73},50,"ESTIMATED","INTERVENTIONAL",[76],"PHASE1","Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis",[79],"Knee Osteoarthrosis",[81,82,17],"osteoarthrosis","Knee","2025-04-13",{"date":85,"type":86},"2025-04-22","ACTUAL",{"date":88,"type":86},"2024-01-01",{"date":90,"type":73},"2027-01-30",{"name":5,"class":6},1]