[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100233413":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":61,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":25,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Hyperpolarized 129 Xenon","EXPERIMENTAL","Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI to optimize acquisition of images for adults vs. proton MR imaging. These scans, utilizing volunteers for calibration, may be utilized through this study to optimize the scan details.",[13,14],"Drug: Hyperpolarized 129 Xenon","Device: MRI",[16,22],{"type":17,"name":9,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans",[9],[21],"HP 129 Xe",{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":25},"DEVICE","MRI",null,[9],[28],{"name":29,"affiliation":5,"role":30},"Jason C Woods, Ph.D.","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Carrie Stevens, BS","CONTACT","513-636-9973","Carrie.Stevens@cchmc.org",{"name":38,"role":34,"phone":39,"phoneExt":25,"email":40},"Kelly Thornton, BS","513-636-0604","Kelly.Thornton@cchmc.org",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Cincinnati Children's Hospital Medical Center","RECRUITING","Cincinnati","Ohio","45229","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-84.51439,39.12711,{"lat":54,"lon":53},[57],{"name":58,"role":34,"phone":59,"phoneExt":25,"email":60},"Jason C Woods, Ph.D","513-803-4463","jason.woods@cchmc.org",{"type":62,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100233413","phase-1-use-of-hyperpolarized-129xe-mr-lung-imaging-in-adults-for-calibration-100233413",false,"NCT02316379","Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration","HpXeMRCal","Inclusion Criteria:\n\n* Adults ages 18 years and older\n* Participant must be able to hold their breath for up to 16 seconds\n\nExclusion Criteria:\n\n* History of heart defect\n* Pregnancy or positive pregnancy test\n* History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.\n* Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.\n* Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.\n* Participant is claustrophobic and unable to tolerate the imaging.\n* Standard MRI exclusions (metal, implants).",true,"ALL","18 Years",{"count":74,"type":75},100,"ESTIMATED","INTERVENTIONAL",[78,79],"PHASE1","PHASE2","The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.",[82],"Respiratory Disorders",[84],"Respiratory","2025-09-03",{"date":87,"type":88},"2025-09-10","ACTUAL",{"date":90,"type":25},"2015-02",{"date":92,"type":75},"2031-08-24",{"name":5,"class":6},1]