[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518454":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":32,"responsibleParty":56,"collaborators":59,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":30,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":30,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":35,"whyStopped":30,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"The Second Hospital of Nanjing Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Washed microbiota transplantation","EXPERIMENTAL","WMT",[13],"Drug: Washed Microbiota Transplantation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Washed Microbiota Transplantation","The prepared microbiota suspension was infused into the participates' lower gut.",[9],[21],"Fecal Microbiota Transplantation",[23],{"name":24,"affiliation":5,"role":25},"Faming Zhang, PhD","PRINCIPAL_INVESTIGATOR",[27],{"name":24,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","086-25-58509883",null,"fzhang@njmu.edu.cn",[33,49],{"facility":34,"status":35,"city":36,"state":37,"zip":30,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Department of Microbiota Medicine & Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University","RECRUITING","Nanjing","Jiangsu","China","CN",{"type":41,"coordinates":42},"Point",[43,44],118.77778,32.06167,{"lat":44,"lon":43},[47],{"name":24,"role":28,"phone":48,"phoneExt":30,"email":31},"086-025-58509883",{"facility":50,"status":35,"city":36,"state":37,"zip":30,"country":38,"countryCode":39,"cosmosGeoPoint":51,"geoPoint":53,"contacts":54},"SIR RUN RUN hospital of Nanjing Medical University",{"type":41,"coordinates":52},[43,44],{"lat":44,"lon":43},[55],{"name":24,"role":28,"phone":29,"phoneExt":30,"email":31},{"type":25,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Faming Zhang","Professor, Gastroenterology",[60],{"name":61,"class":6},"Nanjing Medical University","100518454","phase-1-wmt-for-autism-spectrum-disorder-asd-100518454",false,"NCT06030752","WMT for Autism Spectrum Disorder (ASD)","Washed Microbiota Transplantation (WMT) for Autism Spectrum Disorder (ASD)","Inclusion Criteria:\n\n* Children and adolescents with an established diagnosis of ADHD or ADHD + ASD according to the Diagnostic and Statistical Manual Of Mental Disorders Fifth Edition;.\n* Age 3-17 years.\n* Received stable treatments for ≥1 month preceding WMT\n\nExclusion Criteria:\n\n* Their guardian could not understand the questionnaires or provide informed consent.\n* Diagnosed with a single-gene disorder, major brain malformations, gastrointestinal diseases (ulcerative colitis, Crohn's disease, or eosinophilic esophagitis)\n* Had severe comorbidities including cardiopulmonary failure, severe liver, and kidney diseases, severe infection, tumors, etc.\n* Accompanied with other life-threatening disorders required emergency treatment.\n* Unable to tolerate colonoscopy or anesthesia.","ALL","3 Years","17 Years",{"count":73,"type":74},80,"ESTIMATED","INTERVENTIONAL",[77],"PHASE1","Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. A significant comorbidity exists between ADHD and ASD: 30%-50% of individuals with ASD exhibit ADHD symptoms, and two-thirds with ADHD show ASD traits. Intestinal microbial disturbance is common in children with ASD. A great deal of evidence shows that intestinal microbes can influence the brain to play its role through \"gut-brain-microbiota axis\". We intend to explore the role of Washed Microbiota Transplantation in improving symptoms of children in ASD with or without ADHD; To study the potential etiological mechanism of WMT for the neurodevelopmental disorders.",[80],"Autism Spectrum Disorder",[82,83,84,85],"fecal Microbiota Transplantation","Autism spectrum disorder","Gut microbiota","Gut-brain axis","2025-09-03",{"date":88,"type":89},"2025-09-05","ACTUAL",{"date":91,"type":89},"2023-09-20",{"date":93,"type":74},"2027-05-01",{"name":5,"class":6},2]