[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640827":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":11,"locations":20,"responsibleParty":40,"collaborators":11,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":11,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":11,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":11,"overallStatus":63,"whyStopped":11,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"WestVac Biopharma Co., Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"intrapleural\u002Fintraperitoneal infusion of WSK-IM02","EXPERIMENTAL",null,[13],"Biological: WSK-IM02",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"BIOLOGICAL","WSK-IM02","WSK-IM02 is an injectable pMVA-1 lipid complex",[9],[21],{"facility":22,"status":11,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"West China Hospital of Sichuan University","Chengdu","Sichuan","610041","China","CN",{"type":29,"coordinates":30},"Point",[31,32],104.06667,30.66667,{"lat":32,"lon":31},[35],{"name":36,"role":37,"phone":38,"phoneExt":11,"email":39},"Ting Liu","CONTACT","19182843926","1924658083@qq.com",{"type":41,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100640827","phase-1-wsk-im02-in-advanced-solid-tumors-with-malignant-effusions-phase-i-100640827",false,"NCT07615894","WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I)","A Single-Arm, Open-Label, Prospective Phase I Clinical Study to Evaluate the Safety and Preliminary Efficacy of WSK-IM02 in Patients With Advanced Solid Tumors Complicated by Malignant Pleural or Peritoneal Effusions","Inclusion Criteria:\n\n1. Age ≥18 years and ≤75 years.\n2. Voluntarily sign informed consent form.\n3. Patients with histologically or cytologically confirmed advanced solid tumors.\n4. Histologically or cytologically confirmed malignant pleural\u002Fperitoneal effusion requiring drainage; or, in the absence of histologic\u002Fcytologic evidence, pleural effusion with clear imaging evidence of malignant pleural\u002Fperitoneal lesions on chest\u002Fabdominal CT and diagnosed as malignant pleural\u002Fperitoneal tumor in clinical practice.\n5. Have received standard systemic therapy and developed clinical symptoms of serous cavity metastasis.\n6. ECOG performance status: 0-2 points. Patients with ECOG 3 may be included if, in the investigator's judgment, removal of the effusion could improve the score to 2 or above.\n7. Life expectancy ≥3 months.\n8. Adequate major organ function.\n9. Able to tolerate thoracentesis\u002Fabdominocentesis and catheter placement, or already have a functional thoracic\u002Fabdominal drainage catheter in place, and agree to receive study drug treatment via this route.\n\nExclusion Criteria:\n\n1. Participation in any other interventional clinical trial within 4 weeks prior to the first dose of study drug.\n2. Received local intracavitary therapy for pleural\u002Fperitoneal effusion (excluding diagnostic or symptom-relieving puncture\u002Fdrainage) within 2 weeks prior to the first dose of study drug.\n3. Received extra-thoracic\u002Fextra-abdominal radiotherapy within 2 weeks prior to the first dose of study drug, or received radical radiotherapy to pleural\u002Fperitoneal or pulmonary\u002Fabdominal lesions within 8 weeks prior to enrollment (palliative radiotherapy to chest\u002Fabdomen is permitted).\n4. Underwent major thoracic or abdominal surgery within 4 weeks prior to the first dose of study drug and not fully recovered, or planned to undergo elective major surgery during the study period.\n5. Any toxicity from prior anti-tumor therapy has not recovered to ≤ Grade 1 at the start of study treatment.\n6. Symptomatic, uncontrolled central nervous system (CNS) metastases or leptomeningeal metastases that, in the investigator's judgment, make the patient unsuitable for enrollment.\n7. Known human immunodeficiency virus (HIV) infection, active hepatitis B, active hepatitis C, or active syphilis infection.\n8. Active, uncontrolled infection requiring systemic antibiotics, antivirals, or antifungal therapy.\n9. Pregnant or breastfeeding women.\n10. Definite history of severe mental or cognitive disorders that, in the investigator's opinion, may affect study compliance or safety assessment.\n11. Presence of any active autoimmune disease, or history of autoimmune disease requiring systemic immunosuppressive therapy (topical glucocorticoids or inhaled\u002Fintra-articular steroids are permitted).\n12. Require systemic corticosteroids or other immunosuppressants within 2 weeks prior to the first dose of study drug, and expected to require long-term use during the study.\n13. Have poorly controlled or severe cardiovascular disease.\n14. Have poorly controlled metabolic disease or complete\u002Fsevere gastrointestinal obstruction requiring intervention.\n15. Hypersensitivity to the investigational drug, any of its excipients, liposomal formulations, or kanamycin.\n16. Have had a major thromboembolic event within 6 months prior to the first dose, or have a clear bleeding tendency.\n17. Active local infection at the administration site.\n18. Uncorrectable coagulation dysfunction that would pose a high risk for thoracentesis\u002Fabdominocentesis or catheter placement.\n19. Have any other concurrent, serious, and\u002For uncontrolled medical condition.","ALL","18 Years","75 Years",{"count":53,"type":54},9,"ESTIMATED","INTERVENTIONAL",[57],"PHASE1","This is a prospective, single-center, interventional, phase I, dose-escalation, single-arm study designed to evaluate the safety, tolerability, and preliminary efficacy of intrapleural\u002Fintraperitoneal infusion of WSK-IM02 in patients with advanced solid tumors complicated by malignant pleural or peritoneal effusions who have failed standard of care.",[60,61,62],"Advanced Solid Tumors","Malignant Pleural Effusions","Malignant Ascites","NOT_YET_RECRUITING","2026-05-22",{"date":66,"type":67},"2026-05-29","ACTUAL",{"date":69,"type":54},"2026-06-01",{"date":71,"type":54},"2029-06-30",{"name":5,"class":6},1]