[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100440509":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":48,"centralContacts":52,"locations":61,"responsibleParty":90,"collaborators":39,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":39,"eligibilityCriteria":99,"healthyVolunteers":95,"sex":100,"minAge":101,"maxAge":39,"enrollmentInfo":102,"targetDuration":39,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":64,"whyStopped":39,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Icahn School of Medicine at Mount Sinai","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Intervention plus Active Rhythm","ACTIVE_COMPARATOR","The device will set on a tabletop in a room where the participant spends at least 2 hours in the morning. Using a timer, it will automatically turn on at preferred wakeup times (but no later than 09:00 am) chosen by the participant. Lights will remain on for at least 2 hours and participants will be asked to remain the space that lights are being applied for that period of time.",[13,14],"Device: Circadian-Effective Light","Device: Rhythmic Light",{"label":16,"type":10,"description":11,"interventionNames":17},"Active Light plus Placebo Rhythm",[13,18],"Device: Placebo Rhythmic Light",{"label":20,"type":10,"description":11,"interventionNames":21},"Placebo Light plus Active Rhythm",[14,22],"Device: Placebo Light",{"label":24,"type":25,"description":11,"interventionNames":26},"Placebo Light plus Placebo Rhythm","PLACEBO_COMPARATOR",[22,18],[28,35,40,44],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DEVICE","Circadian-Effective Light","Narrowband blue light",[9,16],[34],"Active Light",{"type":29,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Rhythmic Light","40 hertz (Hz) flicker",[9,20],null,{"type":29,"name":41,"description":42,"armGroupLabels":43,"otherNames":39},"Placebo Light","Narrowband red light",[20,24],{"type":29,"name":45,"description":46,"armGroupLabels":47,"otherNames":39},"Placebo Rhythmic Light","Random flicker for placebo rhythmic effect",[16,24],[49],{"name":50,"affiliation":5,"role":51},"Mariana Figueiro, PhD","PRINCIPAL_INVESTIGATOR",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":39,"email":57},"Barbara Plitnick, BSN","CONTACT","518-242-4603","barbara.plitnick@mountsinai.org",{"name":50,"role":55,"phone":59,"phoneExt":39,"email":60},"518-366-9306","mariana.figueiro@mountsinai.org",[62,80],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Light and Health Research Center","RECRUITING","Menands","New York","12204","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-73.72456,42.69202,{"lat":74,"lon":73},[77],{"name":78,"role":55,"phone":56,"phoneExt":39,"email":79},"Barbara Plitnick, BS","Barbara.Plitnick@mountsinai.org",{"facility":5,"status":64,"city":66,"state":66,"zip":81,"country":68,"countryCode":69,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"10029",{"type":71,"coordinates":83},[84,85],-74.00597,40.71427,{"lat":85,"lon":84},[88],{"name":50,"role":55,"phone":59,"phoneExt":39,"email":89},"Mariana.Figueiro@mountsinai.org",{"type":51,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Mariana Figueiro","Professor, Population Health Science and Policy","100440509","phase-2---rhythmic-light-therapy-for-alzheimers-disease-patients-100440509",false,"NCT05016219","Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients","Phase 2 - The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients With Alzheimer's Disease","Inclusion Criteria:\n\n* Participants must be diagnosed with mild cognitive impairment or mild Alzheimer's disease, as defined by a Montreal Cognitive Assessment score between 17 and 25;\n* Have sleep disturbance indicated by a score \\>5 on the Pittsburgh Sleep Quality Index\n* Participants must reside in their homes, independent living, or assisted living facilities\n\nExclusion Criteria:\n\n* Participants taking sleep medication\n* Residence in a skilled nursing facility or long-term care\n* Obstructing cataracts, macular degeneration, and blindness\n* Severe sleep apnea or restless leg syndrome\n* History of severe epilepsy","ALL","55 Years",{"count":103,"type":104},120,"ESTIMATED","INTERVENTIONAL",[107],"NA","Participants will randomly be placed into one of four groups and experience one of the four following conditions: (1) a placebo light that provides a 40 hertz (Hz) flicker (rhythmic light \\[RL\\]); (2) a placebo light with a random flicker (placebo condition for rhythmic light); (3) a light source that will stimulate the circadian system and provides a 40 Hz flicker (RL); or (4) a light source that will stimulate the circadian system and provides a random flicker (placebo condition for rhythmic light). Following a baseline week, participants will experience his\u002Fher assigned lighting condition for two hours in the morning for 8 weeks. After a 4-week washout period, a final round of assessments will be obtained. Study assessments (except for the Pittsburgh Sleep Quality Index and Montreal Cognitive Assessment) will be collected at the end of each week, for a total of 8 assessments.",[110],"Mild Cognitive Impairment",[112,113,114,36,115,116],"Light Treatment","Circadian Rhythms","Gamma Wave Entrainment","Sleep","Cognition","2026-05-26",{"date":119,"type":120},"2026-05-29","ACTUAL",{"date":122,"type":120},"2023-08-22",{"date":124,"type":104},"2027-07-31",{"name":5,"class":6},2]