[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543090":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":50,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":19,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Duke University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Pulmonary Arterial Hypertension Patients Receving Sotatercept","PAH patients receiving sotatercept as treatment for their PAH",[12],"Drug: 129Xe Hyperpolarized",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","129Xe Hyperpolarized","Each xenon dose will be limited to a volume less than 25% of participant lung capacity (TLC).",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Sudarshan Rajagopal, MD, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Claudia Salazar","CONTACT","+1 919 660 2026","claudia.salazar@duke.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Duke University Medical Center","RECRUITING","Durham","North Carolina","27710","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-78.89862,35.99403,{"lat":43,"lon":42},[46,49],{"name":47,"role":27,"phone":48,"phoneExt":19,"email":29},"Claudia Salazar, BS","919-660-2026",{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Bastiaan Driehuys","Professor of Radiology",[55],{"name":56,"class":57},"Merck Sharp & Dohme LLC","INDUSTRY","100543090","phase-2-129-xenon-imaging-in-patients-treated-with-sotatercept-100543090",false,"NCT06351345","129 Xenon Imaging in Patients Treated With Sotatercept","129Xenon MR Imaging and Spectroscopy Response to Sotatercept in Pulmonary Arterial Hypertension","Sox-PH","Inclusion Criteria:\n\n1. Outpatients of either gender, Age 18-75\n2. Diagnosis of precapillary PH (right heart catheterization demonstrating hemodynamic criteria of a mean pulmonary artery pressure (mPAP) ≥ 20 mmHg, pulmonary vascular resistance ≥ 5 WU, pulmonary capillary wedge pressure ≤ 15 mmHg) in the setting of Group 1 (PAH)\n3. Willing and giving informed consent and adhere to visit\u002Fprotocol schedules (consent must be given before any study procedures are performed).\n4. On a stable dose of background PAH therapy for \\> 90 days prior to study enrollment\n5. Women of childbearing potential must have a negative urine pregnancy test before MRI\n\nExclusion Criteria:\n\n1. Moderate to severe heart disease (LVEF \\\u003C 45%, Severe LV hypertrophy, Moderate to severe valvular disease)\n2. Chronic thromboembolic disease\n3. PH due to schistosomiasis\n4. Active cancer\n5. Sickle cell anemia\n6. Prisoners and pregnant women will not be approached for the study\n7. Conditions that will prohibit MRI scanning (metal in eye, claustrophobia, inability to lie supine)\n8. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the participant or interfere with the participant's ability to comply with the protocol requirements","ALL","18 Years","75 Years",{"count":70,"type":71},14,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","Determine the ability of 129Xe MRI\u002FMRS biomarker signatures to non-invasively monitor pulmonary vascular reverse remodeling induced by sotatercept in pulmonary arterial hypertension (PAH).",[77,78],"Pulmonary Hypertension","Pulmonary Arterial Hypertension",[80,81],"Xenon","MRI","2026-02-23",{"date":84,"type":85},"2026-02-24","ACTUAL",{"date":87,"type":85},"2025-10-27",{"date":89,"type":71},"2030-02-04",{"name":52,"class":6},1]