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0905)","Plymouth","PL68DH",{"type":95,"coordinates":1659},[1660,1661],-4.14305,50.37153,{"lat":1661,"lon":1660},[1664],{"name":102,"role":82,"phone":1665,"phoneExt":64,"email":64},"+441752431043",{"facility":1667,"status":88,"city":1668,"state":1669,"zip":1670,"country":1618,"countryCode":1619,"cosmosGeoPoint":1671,"geoPoint":1675,"contacts":1676},"The James Cook University Hospital ( Site 0909)","Middlesbrough","England","TS4 3BW",{"type":95,"coordinates":1672},[1673,1674],-1.23483,54.57623,{"lat":1674,"lon":1673},[1677],{"name":102,"role":82,"phone":1678,"phoneExt":64,"email":64},"+441642850850",{"facility":1680,"status":88,"city":501,"state":1681,"zip":1682,"country":1618,"countryCode":1619,"cosmosGeoPoint":1683,"geoPoint":1687,"contacts":1688},"Lincoln County Hospital ( Site 0906)","Lincolnshire","LN2 5QY",{"type":95,"coordinates":1684},[1685,1686],-0.53792,53.22683,{"lat":1686,"lon":1685},[1689],{"name":102,"role":82,"phone":1690,"phoneExt":64,"email":64},"+441522573557",{"facility":1692,"status":88,"city":1693,"state":1694,"zip":1695,"country":1618,"countryCode":1619,"cosmosGeoPoint":1696,"geoPoint":1700,"contacts":1701},"Guy s & St Thomas NHS Foundation Trust ( Site 0904)","London","London, City of","SE1 9RT",{"type":95,"coordinates":1697},[1698,1699],-0.12574,51.50853,{"lat":1699,"lon":1698},[1702],{"name":102,"role":82,"phone":1703,"phoneExt":64,"email":64},"+442071887188",{"facility":1705,"status":88,"city":1693,"state":1694,"zip":1706,"country":1618,"countryCode":1619,"cosmosGeoPoint":1707,"geoPoint":1709,"contacts":1710},"Hammersmith Hospital ( Site 0915)","W12 0 HS",{"type":95,"coordinates":1708},[1698,1699],{"lat":1699,"lon":1698},[1711],{"name":102,"role":82,"phone":1712,"phoneExt":64,"email":64},"+442033134594",{"facility":1714,"status":88,"city":1715,"state":1716,"zip":1717,"country":1618,"countryCode":1619,"cosmosGeoPoint":1718,"geoPoint":1722,"contacts":1723},"Churchill Hospital ( Site 0903)","Oxford","Oxfordshire","OX3 7LJ",{"type":95,"coordinates":1719},[1720,1721],-1.25596,51.75222,{"lat":1721,"lon":1720},[1724],{"name":102,"role":82,"phone":1725,"phoneExt":64,"email":64},"+441865227063",{"facility":1727,"status":88,"city":1728,"state":64,"zip":1729,"country":1618,"countryCode":1619,"cosmosGeoPoint":1730,"geoPoint":1734,"contacts":1735},"Queen Elizabeth Hospital Birmingham ( Site 0912)","Birmingham","B15 2TH",{"type":95,"coordinates":1731},[1732,1733],-1.89983,52.48142,{"lat":1733,"lon":1732},[1736],{"name":102,"role":82,"phone":1737,"phoneExt":64,"email":64},"+441213717842",{"facility":1739,"status":88,"city":1740,"state":64,"zip":1741,"country":1618,"countryCode":1619,"cosmosGeoPoint":1742,"geoPoint":1746,"contacts":1747},"Clatterbridge Cancer Centre - Liverpool ( Site 0911)","Liverpool","L7 8YA",{"type":95,"coordinates":1743},[1744,1745],-2.97794,53.41058,{"lat":1745,"lon":1744},[1748],{"name":102,"role":82,"phone":1749,"phoneExt":64,"email":64},"+441515565000",{"facility":1751,"status":88,"city":1752,"state":64,"zip":1753,"country":1618,"countryCode":1619,"cosmosGeoPoint":1754,"geoPoint":1758,"contacts":1759},"Christie Hospital NHS Trust ( Site 0901)","Manchester","M20 4BX",{"type":95,"coordinates":1755},[1756,1757],-2.23743,53.48095,{"lat":1757,"lon":1756},[1760],{"name":102,"role":82,"phone":1761,"phoneExt":64,"email":64},"+441619187222",{"type":1763,"investigatorFullName":64,"investigatorTitle":64,"investigatorAffiliation":64,"oldNameTitle":64,"oldOrganization":64},"SPONSOR","100053501","phase-2-a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-rituximab-plus-cyclophosphamide-doxorubicin-and-prednisone-r-chp-versus-polatuzumab-vedotin-plus-r-chp-in-people-with-diffuse-large-b-cell-lymphoma-dlbcl-mk-2140-011waveline-011-100053501",false,"NCT06890884","A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011\u002FwaveLINE-011)","A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically confirmed diagnosis of germinal center B-cell (GCB) subtype of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, according to the World Health Organization (WHO) classification of neoplasms of the hematopoietic and lymphoid tissues.\n* Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale.\n* Has received no prior treatment for their DLBCL.\n* Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART).\n* Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization.\n* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a history of transformation of indolent disease to DLBCL.\n* Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma.\n* Has Ann Arbor Stage I DLBCL.\n* Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident\u002Fstroke (\\\u003C6 months prior to enrollment), myocardial infarction (\\\u003C6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication.\n* Has clinically significant pericardial or pleural effusion.\n* Has ongoing Grade \\>1 peripheral neuropathy.\n* Has a demyelinating form of Charcot-Marie-Tooth disease.\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease.\n* Has ongoing corticosteroid therapy.\n* Known additional malignancy that is progressing or has required active treatment within the past 2 years.\n* Known active central nervous system (CNS) lymphoma.\n* Has active autoimmune disease that has required systemic treatment in the past 2 years.\n* Has active infection requiring systemic therapy.\n* Has active HBV (defined as HBsAg positive and detectable HBV deoxyribonucleic acid (DNA)) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection.\n* Has history of stem cell\u002Fsolid organ transplant.","ALL","18 Years",{"count":1774,"type":1775},594,"ESTIMATED","INTERVENTIONAL",[1778],"PHASE2","Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing.\n\nThe goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.",[1781],"Lymphoma, Large B-Cell, Diffuse","2026-07-10",{"date":1784,"type":1785},"2026-07-13","ACTUAL",{"date":1787,"type":1785},"2025-04-11",{"date":1789,"type":1775},"2032-12-16",{"name":5,"class":6},136]