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HS",{"type":95,"coordinates":1673},[1663,1664],{"lat":1664,"lon":1663},[1676],{"name":102,"role":82,"phone":1677,"phoneExt":64,"email":64},"+442033134594",{"facility":1679,"status":88,"city":1680,"state":1681,"zip":1682,"country":1583,"countryCode":1584,"cosmosGeoPoint":1683,"geoPoint":1687,"contacts":1688},"Churchill Hospital ( Site 0903)","Oxford","Oxfordshire","OX3 7LJ",{"type":95,"coordinates":1684},[1685,1686],-1.25596,51.75222,{"lat":1686,"lon":1685},[1689],{"name":102,"role":82,"phone":1690,"phoneExt":64,"email":64},"+441865227063",{"facility":1692,"status":88,"city":1693,"state":64,"zip":1694,"country":1583,"countryCode":1584,"cosmosGeoPoint":1695,"geoPoint":1699,"contacts":1700},"Queen Elizabeth Hospital Birmingham ( Site 0912)","Birmingham","B15 2TH",{"type":95,"coordinates":1696},[1697,1698],-1.89983,52.48142,{"lat":1698,"lon":1697},[1701],{"name":102,"role":82,"phone":1702,"phoneExt":64,"email":64},"+441213717842",{"facility":1704,"status":88,"city":1705,"state":64,"zip":1706,"country":1583,"countryCode":1584,"cosmosGeoPoint":1707,"geoPoint":1711,"contacts":1712},"Clatterbridge Cancer Centre - Liverpool ( Site 0911)","Liverpool","L7 8YA",{"type":95,"coordinates":1708},[1709,1710],-2.97794,53.41058,{"lat":1710,"lon":1709},[1713],{"name":102,"role":82,"phone":1714,"phoneExt":64,"email":64},"+441515565000",{"facility":1716,"status":88,"city":1717,"state":64,"zip":1718,"country":1583,"countryCode":1584,"cosmosGeoPoint":1719,"geoPoint":1723,"contacts":1724},"Christie Hospital NHS Trust ( Site 0901)","Manchester","M20 4BX",{"type":95,"coordinates":1720},[1721,1722],-2.23743,53.48095,{"lat":1722,"lon":1721},[1725],{"name":102,"role":82,"phone":1726,"phoneExt":64,"email":64},"+441619187222",{"type":1728,"investigatorFullName":64,"investigatorTitle":64,"investigatorAffiliation":64,"oldNameTitle":64,"oldOrganization":64},"SPONSOR","100584556",false,"NCT06890884","A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011\u002FwaveLINE-011)","A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically confirmed diagnosis of germinal center B-cell (GCB) subtype of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, according to the World Health Organization (WHO) classification of neoplasms of the hematopoietic and lymphoid tissues.\n* Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale.\n* Has received no prior treatment for their DLBCL.\n* Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART).\n* Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization.\n* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a history of transformation of indolent disease to DLBCL.\n* Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma.\n* Has Ann Arbor Stage I DLBCL.\n* Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident\u002Fstroke (\\\u003C6 months prior to enrollment), myocardial infarction (\\\u003C6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication.\n* Has clinically significant pericardial or pleural effusion.\n* Has ongoing Grade \\>1 peripheral neuropathy.\n* Has a demyelinating form of Charcot-Marie-Tooth disease.\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease.\n* Has ongoing corticosteroid therapy.\n* Known additional malignancy that is progressing or has required active treatment within the past 2 years.\n* Known active central nervous system (CNS) lymphoma.\n* Has active autoimmune disease that has required systemic treatment in the past 2 years.\n* Has active infection requiring systemic therapy.\n* Has active HBV (defined as HBsAg positive and detectable HBV deoxyribonucleic acid (DNA)) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection.\n* Has history of stem cell\u002Fsolid organ transplant.","ALL","18 Years",{"count":1738,"type":1739},594,"ESTIMATED","INTERVENTIONAL",[1742],"PHASE2","Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing.\n\nThe goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.",[1745],"Lymphoma, Large B-Cell, Diffuse","2026-06-30",{"date":1748,"type":1749},"2026-07-02","ACTUAL",{"date":1751,"type":1749},"2025-04-11",{"date":1753,"type":1739},"2032-12-16",{"name":5,"class":6},133]