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prior to the first dose;\n* Individuals with a history of psychiatric drug abuse who are unable to quit or have mental disorders;\n* Subjects with the presence of any severe and\u002For uncontrolled disease；\n* Subjects who have received other antitumor drugs such as chemotherapy, radiotherapy, or immunotherapy within 4 weeks prior to the first dose, or who are still within the 5 half-life of the drug (whichever occurs shortest); have received a proprietary Chinese medicine with an antitumor indication as specified in the National Medical Products Administration(NMPA) -approved drug insert within 2 weeks prior to the first dose; and have experienced any hemorrhagic or bleeding event in the month prior to the initiation of study treatment ≥CTC Patients with AE grade 3;\n* Subjects with known Central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Presence of severe bone damage and spinal cord compression due to tumor bone metastases;\n* History of live attenuated vaccination within 28 days prior to the first dose or planned live attenuated vaccination during the study;\n* History of severe hypersensitivity reactions to large molecule drugs or hypersensitivity to known components of TQB2102, benmelstobart or pembrolizumab for injection;\n* Active autoimmune disease requiring systemic therapy (e.g., use of disease-mitigating drugs, corticosteroids, or immunosuppressive agents) within 2 years prior to the first dose of medication\n* Diagnosis of immunodeficiency or undergoing systemic glucocorticoid therapy or any other form of immunosuppressive therapy that was continued within 2 weeks prior to initiation of study treatment.\n* Participants who have participated in and used other anti-tumor clinical trial drugs within 4 weeks before the first medication use\n* Unstable or serious concurrent medical conditions, as assessed by the Investigators, that would substantially increase the risk-benefit ratio of participating in the study.","ALL","18 Years","75 Years",{"count":616,"type":617},204,"ESTIMATED","INTERVENTIONAL",[620],"PHASE2","TQB2102 for injection is a novel antibody-coupled drug (ADC) that enhances binding to tumor cell surface HER2 proteins by simultaneously targeting the two non-overlapping epitopes of the HER2 protein, Endothelial Cell Dysfunction 2 (ECD2) and Endothelial Cell Dysfunction 4 (ECD4), increasing HER2 internalization, and then down-regulating the tumor cell surface HER2 proteins more effectively, and doubly blocking the HER2 signaling, to achieve the effects of trastuzumab and Pertuzumab alone and in combination. This is a Phase II study to evaluate the efficacy and safety of TQB2102 for injection in combination with Benmelstobart Injection \u002FPenpulimab Injection ± chemotherapy in patients with unresectable locally advanced, recurrent or metastatic HER2-positive gastroesophageal adenocarcinoma",[623],"Gastroesophageal Adenocarcinoma","2025-07-28",{"date":626,"type":627},"2025-07-30","ACTUAL",{"date":629,"type":627},"2024-11-21",{"date":631,"type":617},"2027-09",{"name":633,"class":6},"Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.",39]