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Height assessment corresponding to a height Z-score of ≤ -2.25 SDs in reference to the general population of the same age and sex, as calculated using the Centers for Disease Control and Prevention (CDC) growth charts\n2. If participant is ≥ 5 years at Screening,must be Tanner Stage I to be eligible for enrollment and randomization3. Historic stimulation test result with serum or plasma GH level greater than 10 μg\u002FL or serum IGF-1 in the normal range for age (≥ -1.00 SDs and ≤+2.00 SDs).\n\nKey Exclusions:\n\n1. Known chromosomal imbalance or genetic variant causing short stature syndrome, including but not limited to Laron syndrome, Prader-Willi syndrome, Russell-Silver Syndrome, Turner syndrome, disproportionate skeletal dysplasias, abnormal SHOX gene analysis, or Rasopathy (including Noonan syndrome), ACAN deficiency.\n2. Previous treatment with a growth promoting agent","ALL","3 Years","11 Years",{"count":725,"type":726},100,"ESTIMATED","INTERVENTIONAL",[729],"PHASE2","The purpose of this study is to evaluate i) the effect of multiple doses of vosoritide and ii) the effect of the therapeutic dose of vosoritide compared to human growth hormone (hGH)(hGH; only in the United States), in children with idiopathic short stature (ISS).",[732],"Idiopathic Short Stature","2026-05-20",{"date":735,"type":736},"2026-05-22","ACTUAL",{"date":738,"type":736},"2024-10-21",{"date":740,"type":726},"2036-12",{"name":5,"class":6},47]