[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594205":3},{"organization":4,"armGroups":7,"interventions":39,"overallOfficials":45,"centralContacts":54,"locations":61,"responsibleParty":852,"collaborators":45,"id":854,"slug":855,"hasResults":856,"nctId":857,"briefTitle":858,"officialTitle":859,"acronym":45,"eligibilityCriteria":860,"healthyVolunteers":856,"sex":861,"minAge":862,"maxAge":863,"enrollmentInfo":864,"targetDuration":45,"studyType":867,"phases":868,"briefSummary":870,"conditions":871,"keywords":873,"overallStatus":64,"whyStopped":45,"lastUpdateSubmitDate":877,"lastUpdatePostDateStruct":878,"startDateStruct":881,"completionDateStruct":883,"leadSponsor":885,"locationsCount":886},{"fullName":5,"class":6},"Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA","INDUSTRY",[8,15,20,25,29,33],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Arm A: Ensifentrine plus Glycopyrrolate","EXPERIMENTAL","Ensifentrine 3 mg \u002F Glycopyrrolate 42.5 mcg",[13,14],"Drug: Ensifentrine 3 mg","Drug: Glycopyrrolate 42.5 mcg",{"label":16,"type":10,"description":17,"interventionNames":18},"Treatment Arm B: Ensifentrine plus Glycopyrrolate","Ensifentrine 3 mg \u002F Glycopyrrolate 21.25 mcg",[13,19],"Drug: Glycopyrrolate 21.25 mcg",{"label":21,"type":22,"description":23,"interventionNames":24},"Treatment Arm C: Glycopyrrolate","ACTIVE_COMPARATOR","Glycopyrrolate monotherapy 42.5 mcg",[14],{"label":26,"type":22,"description":27,"interventionNames":28},"Treatment Arm D: Glycopyrrolate","Glycopyrrolate monotherapy 21.25 mcg",[19],{"label":30,"type":22,"description":31,"interventionNames":32},"Treatment Arm E: Ensifentrine","Ensifentrine monotherapy 3 mg",[13],{"label":34,"type":35,"description":36,"interventionNames":37},"Treatment Arm F: Placebo","PLACEBO_COMPARATOR","Placebo",[38],"Drug: Placebo",[40,46,49,52],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"DRUG","Ensifentrine 3 mg","Administered by a standard jet nebulizer, twice daily for 28 consecutive days",[9,16,30],null,{"type":41,"name":47,"description":43,"armGroupLabels":48,"otherNames":45},"Glycopyrrolate 21.25 mcg",[16,26],{"type":41,"name":50,"description":43,"armGroupLabels":51,"otherNames":45},"Glycopyrrolate 42.5 mcg",[9,21],{"type":41,"name":36,"description":43,"armGroupLabels":53,"otherNames":45},[34],[55],{"name":56,"role":57,"phone":58,"phoneExt":59,"email":60},"Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway Toll Free Number","CONTACT","Reach out by phone or email","1-888-577-8839","Trialsites@msd.com",[62,81,96,111,125,139,154,168,182,196,210,224,239,249,264,278,293,308,324,339,353,364,375,390,405,420,434,448,462,476,491,504,518,533,547,562,576,590,604,618,628,642,656,667,678,693,704,718,728,743,757,771,785,796,810,824,838],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"SEC Clinical Research, LLC","RECRUITING","Dothan","Alabama","36305-7375","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-85.39049,31.22323,{"lat":74,"lon":73},[77],{"name":78,"role":57,"phone":79,"phoneExt":45,"email":80},"Stefani Dykes","13346991632","sdykes@secclinicalresearch.com",{"facility":82,"status":64,"city":83,"state":84,"zip":85,"country":68,"countryCode":69,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Elite Clinical Studies, LLC","Phoenix","Arizona","85018",{"type":71,"coordinates":87},[88,89],-112.07404,33.44838,{"lat":89,"lon":88},[92],{"name":93,"role":57,"phone":94,"phoneExt":45,"email":95},"Evette Miguel","6027883437","evette@eliteclinicalstudies.com",{"facility":97,"status":64,"city":98,"state":99,"zip":100,"country":68,"countryCode":69,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Downtown LA Research Center Inc - ClinEdge","Los Angeles","California","90017",{"type":71,"coordinates":102},[103,104],-118.24368,34.05223,{"lat":104,"lon":103},[107],{"name":108,"role":57,"phone":109,"phoneExt":45,"email":110},"Claudia Cisneros","2132613680","ccisneros@dtlaresearch.com",{"facility":112,"status":64,"city":113,"state":99,"zip":114,"country":68,"countryCode":69,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"California Medical Research Associates, Inc.","Northridge","91324-6200",{"type":71,"coordinates":116},[117,118],-118.53675,34.22834,{"lat":118,"lon":117},[121],{"name":122,"role":57,"phone":123,"phoneExt":45,"email":124},"Pulasthi Karunatillaka","8183250200","pulasthi.cmra@gmail.com",{"facility":126,"status":64,"city":127,"state":99,"zip":128,"country":68,"countryCode":69,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Northern California Research Corp","Sacramento","95821-2640",{"type":71,"coordinates":130},[131,132],-121.4944,38.58157,{"lat":132,"lon":131},[135],{"name":136,"role":57,"phone":137,"phoneExt":45,"email":138},"Jesika Riley","9164840500","jriley@norcare.net",{"facility":140,"status":64,"city":141,"state":142,"zip":143,"country":68,"countryCode":69,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Clinical Research of West Florida Inc","Clearwater","Florida","33765",{"type":71,"coordinates":145},[146,147],-82.8001,27.96585,{"lat":147,"lon":146},[150],{"name":151,"role":57,"phone":152,"phoneExt":45,"email":153},"Maartje Brucculeri","727-4660078","mbrucculeri@crwf.com",{"facility":155,"status":64,"city":156,"state":142,"zip":157,"country":68,"countryCode":69,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Fleming Island Center For Clinical Research","Fleming Island","32003",{"type":71,"coordinates":159},[160,161],-81.71898,30.0933,{"lat":161,"lon":160},[164],{"name":165,"role":57,"phone":166,"phoneExt":45,"email":167},"Shanda Nicco","904-6210390","snicco@encoredocs.com",{"facility":169,"status":64,"city":170,"state":142,"zip":171,"country":68,"countryCode":69,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Florida Institute For Clinical Research LLC","Orlando","32825-4454",{"type":71,"coordinates":173},[174,175],-81.37924,28.53834,{"lat":175,"lon":174},[178],{"name":179,"role":57,"phone":180,"phoneExt":45,"email":181},"Maria Lopez","407-6580966","mlopez@ficresearch.com",{"facility":183,"status":64,"city":184,"state":142,"zip":185,"country":68,"countryCode":69,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Ormond Beach Clinical Research","Ormond Beach","32174-8196",{"type":71,"coordinates":187},[188,189],-81.05589,29.28581,{"lat":189,"lon":188},[192],{"name":193,"role":57,"phone":194,"phoneExt":45,"email":195},"Nicole Davis","386-3107462","obcrngyurkovics@gmail.com",{"facility":197,"status":64,"city":198,"state":142,"zip":199,"country":68,"countryCode":69,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Progressive Medical Research","Port Orange","32127-5169",{"type":71,"coordinates":201},[202,203],-80.99561,29.13832,{"lat":203,"lon":202},[206],{"name":207,"role":57,"phone":208,"phoneExt":45,"email":209},"Josefina McGeehan","386-3047070","ninam@progressivemedicalresearch.com",{"facility":211,"status":64,"city":212,"state":142,"zip":213,"country":68,"countryCode":69,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Clinical Research of West Florida Inc - Tampa","Tampa","33606",{"type":71,"coordinates":215},[216,217],-82.45843,27.94752,{"lat":217,"lon":216},[220],{"name":221,"role":57,"phone":222,"phoneExt":45,"email":223},"Kyndall Carter","813-8701292","KCarter@crwf.com",{"facility":225,"status":64,"city":226,"state":227,"zip":228,"country":68,"countryCode":69,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Centricity Research Columbus Georgia Multispecialty - PPDS","Columbus","Georgia","31904",{"type":71,"coordinates":230},[231,232],-84.98771,32.46098,{"lat":232,"lon":231},[235],{"name":236,"role":57,"phone":237,"phoneExt":45,"email":238},"Emily Gilder","706-3210495","Emily.gilder@centricityresearch.com",{"facility":240,"status":241,"city":242,"state":227,"zip":243,"country":68,"countryCode":69,"cosmosGeoPoint":244,"geoPoint":248,"contacts":45},"Southeast Lung Associates Research","WITHDRAWN","Rincon","31326",{"type":71,"coordinates":245},[246,247],-81.23539,32.29603,{"lat":247,"lon":246},{"facility":250,"status":64,"city":251,"state":252,"zip":253,"country":68,"countryCode":69,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"ASHA Clinical Research - Hammond","Hammond","Indiana","46324",{"type":71,"coordinates":255},[256,257],-87.50004,41.58337,{"lat":257,"lon":256},[260],{"name":261,"role":57,"phone":262,"phoneExt":45,"email":263},"Keerthana Kolluri","219-8036649","Keerthana@ashaclinicalresearch.com",{"facility":265,"status":64,"city":266,"state":252,"zip":267,"country":68,"countryCode":69,"cosmosGeoPoint":268,"geoPoint":272,"contacts":273},"Velocity Clinical Research - Valparaiso","Valparaiso","46383",{"type":71,"coordinates":269},[270,271],-87.06114,41.47309,{"lat":271,"lon":270},[274],{"name":275,"role":57,"phone":276,"phoneExt":45,"email":277},"Megan Smith","219-4648302","msmith@velocityclinical.com",{"facility":279,"status":64,"city":280,"state":281,"zip":282,"country":68,"countryCode":69,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"Velocity Clinical Research (Rockville - Maryland) - PPDS","Rockville","Maryland","20854-2960",{"type":71,"coordinates":284},[285,286],-77.15276,39.084,{"lat":286,"lon":285},[289],{"name":290,"role":57,"phone":291,"phoneExt":45,"email":292},"Martha Demissew","2406982800","mdemissew@velocityclinical.com",{"facility":294,"status":64,"city":295,"state":296,"zip":297,"country":68,"countryCode":69,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"Revive Research Institute, Inc","Southfield","Michigan","48075",{"type":71,"coordinates":299},[300,301],-83.22187,42.47337,{"lat":301,"lon":300},[304],{"name":305,"role":57,"phone":306,"phoneExt":45,"email":307},"Abhishek Dhillon","248-8293103","adhillon@rev-research.com",{"facility":309,"status":64,"city":310,"state":311,"zip":312,"country":68,"countryCode":69,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"Clinical Research Institute, Inc - CRN","Plymouth","Minnesota","55441-2676",{"type":71,"coordinates":314},[315,316],-93.45551,45.01052,{"lat":316,"lon":315},[319],{"name":320,"role":57,"phone":321,"phoneExt":322,"email":323},"Meckey Nguyen","612-333-2200","360","meckey.nguyen@criminnesota.com",{"facility":325,"status":64,"city":326,"state":327,"zip":328,"country":68,"countryCode":69,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Midwest Chest Consultants PC","Saint Charles","Missouri","63301",{"type":71,"coordinates":330},[331,332],-90.48123,38.78394,{"lat":332,"lon":331},[335],{"name":336,"role":57,"phone":337,"phoneExt":45,"email":338},"Krista Mueller","16369461650","kristahag@yahoo.com",{"facility":340,"status":64,"city":341,"state":327,"zip":342,"country":68,"countryCode":69,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Midwest Clinical Research LLC","St Louis","63141-7051",{"type":71,"coordinates":344},[345,346],-90.19789,38.62727,{"lat":346,"lon":345},[349],{"name":350,"role":57,"phone":351,"phoneExt":45,"email":352},"Martha Kelley","314-9915117","martha@stlouisresearch.com",{"facility":354,"status":64,"city":341,"state":327,"zip":355,"country":68,"countryCode":69,"cosmosGeoPoint":356,"geoPoint":358,"contacts":359},"The Clinical Research Center LLC - CRN","63141",{"type":71,"coordinates":357},[345,346],{"lat":346,"lon":345},[360],{"name":361,"role":57,"phone":362,"phoneExt":45,"email":363},"Amelia Ayotte","3145148509","a.ayotte@clinicalresearchcenter.com",{"facility":365,"status":366,"city":367,"state":368,"zip":369,"country":68,"countryCode":69,"cosmosGeoPoint":370,"geoPoint":374,"contacts":45},"Sierra Clinical Research","TERMINATED","Las Vegas","Nevada","89106",{"type":71,"coordinates":371},[372,373],-115.13722,36.17497,{"lat":373,"lon":372},{"facility":376,"status":64,"city":377,"state":378,"zip":379,"country":68,"countryCode":69,"cosmosGeoPoint":380,"geoPoint":384,"contacts":385},"Trialfinity Clinical Research Center","Hamilton","New Jersey","08619",{"type":71,"coordinates":381},[382,383],-74.08125,40.20706,{"lat":383,"lon":382},[386],{"name":387,"role":57,"phone":388,"phoneExt":45,"email":389},"Sreenivasa Nallapareddygari","810-6245088","info.trialfinity@gmail.com",{"facility":391,"status":64,"city":392,"state":393,"zip":394,"country":68,"countryCode":69,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"Horizon Family Medical Group - New Windsor Primary Care","New Windsor","New York","12553-7754",{"type":71,"coordinates":396},[397,398],-74.02375,41.47676,{"lat":398,"lon":397},[401],{"name":402,"role":57,"phone":403,"phoneExt":45,"email":404},"Carlos Velasquez","845-6749398","cvelasquez@mhmresearch.com",{"facility":406,"status":64,"city":407,"state":408,"zip":409,"country":68,"countryCode":69,"cosmosGeoPoint":410,"geoPoint":414,"contacts":415},"American Health Research Inc","Charlotte","North Carolina","28277",{"type":71,"coordinates":411},[412,413],-80.84313,35.22709,{"lat":413,"lon":412},[416],{"name":417,"role":57,"phone":418,"phoneExt":45,"email":419},"Connie Divel","7049268041","cdivel@ahres.com",{"facility":421,"status":64,"city":422,"state":408,"zip":423,"country":68,"countryCode":69,"cosmosGeoPoint":424,"geoPoint":428,"contacts":429},"Clinical Research of Gastonia","Gastonia","28054-7481",{"type":71,"coordinates":425},[426,427],-81.1873,35.26208,{"lat":427,"lon":426},[430],{"name":431,"role":57,"phone":432,"phoneExt":45,"email":433},"Jessica Parker","704-6757144","jparker@crgastonia.com",{"facility":435,"status":64,"city":436,"state":408,"zip":437,"country":68,"countryCode":69,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"Stern Research Partners, LLC","Huntersville","28078",{"type":71,"coordinates":439},[440,441],-80.84285,35.41069,{"lat":441,"lon":440},[444],{"name":445,"role":57,"phone":446,"phoneExt":45,"email":447},"Felix Kurniawan","704-6590090","felix@arsmnc.com",{"facility":449,"status":64,"city":450,"state":408,"zip":451,"country":68,"countryCode":69,"cosmosGeoPoint":452,"geoPoint":456,"contacts":457},"Monroe Biomedical Research -343 Venus St","Monroe","28112-4025",{"type":71,"coordinates":453},[454,455],-80.54951,34.98543,{"lat":455,"lon":454},[458],{"name":459,"role":57,"phone":460,"phoneExt":45,"email":461},"Krista Gross","704-2837359","Krista.gross@monroeresearch.com",{"facility":463,"status":64,"city":464,"state":408,"zip":465,"country":68,"countryCode":69,"cosmosGeoPoint":466,"geoPoint":470,"contacts":471},"Carolina Research Center, Inc","Shelby","28150-3803",{"type":71,"coordinates":467},[468,469],-81.53565,35.29235,{"lat":469,"lon":468},[472],{"name":473,"role":57,"phone":474,"phoneExt":45,"email":475},"Aimee Scronce","704-6006052","aimeescroncecrc@yahoo.com",{"facility":477,"status":64,"city":478,"state":479,"zip":480,"country":68,"countryCode":69,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"Bernstein Clinical Research Center Inc","Cincinnati","Ohio","45231-4927",{"type":71,"coordinates":482},[483,484],-84.51439,39.12711,{"lat":484,"lon":483},[487],{"name":488,"role":57,"phone":489,"phoneExt":45,"email":490},"Karen Berendts","513-3541746","kberendts@bernsteincrc.com",{"facility":492,"status":64,"city":226,"state":479,"zip":493,"country":68,"countryCode":69,"cosmosGeoPoint":494,"geoPoint":498,"contacts":499},"Remington Davis Clinical Research","43215",{"type":71,"coordinates":495},[496,497],-82.99879,39.96118,{"lat":497,"lon":496},[500],{"name":501,"role":57,"phone":502,"phoneExt":45,"email":503},"Eve Horrigan","614-4872560","ehorrigan@remdavis.com",{"facility":505,"status":64,"city":506,"state":479,"zip":507,"country":68,"countryCode":69,"cosmosGeoPoint":508,"geoPoint":512,"contacts":513},"Advance Clinical Research","Kettering","45439",{"type":71,"coordinates":509},[510,511],-84.16883,39.6895,{"lat":511,"lon":510},[514],{"name":515,"role":57,"phone":516,"phoneExt":45,"email":517},"Kelvin OnyiaEze","9377161775","kelvin.onyiaeze@advanceclinicalresearch.com",{"facility":519,"status":64,"city":520,"state":521,"zip":522,"country":68,"countryCode":69,"cosmosGeoPoint":523,"geoPoint":527,"contacts":528},"Clinical Research Associates of Central PA","DuBois","Pennsylvania","15801-2277",{"type":71,"coordinates":524},[525,526],-78.76003,41.11923,{"lat":526,"lon":525},[529],{"name":530,"role":57,"phone":531,"phoneExt":45,"email":532},"Amber Witherow","8146618837","awitherow@lunginnovations.com",{"facility":534,"status":64,"city":535,"state":521,"zip":536,"country":68,"countryCode":69,"cosmosGeoPoint":537,"geoPoint":541,"contacts":542},"University of Pittsburgh Medical Center","Pittsburgh","15213",{"type":71,"coordinates":538},[539,540],-79.99589,40.44062,{"lat":540,"lon":539},[543],{"name":544,"role":57,"phone":545,"phoneExt":45,"email":546},"Paula Consolaro","4126486404","consolaropj@upmc.edu",{"facility":548,"status":64,"city":549,"state":550,"zip":551,"country":68,"countryCode":69,"cosmosGeoPoint":552,"geoPoint":556,"contacts":557},"Velocity Clinical Research - Anderson - PPDS","Anderson","South Carolina","29621-4822",{"type":71,"coordinates":553},[554,555],-82.65013,34.50344,{"lat":555,"lon":554},[558],{"name":559,"role":57,"phone":560,"phoneExt":45,"email":561},"Sara Rauenhorst","8649650190","srauenhorst@velocityclinical.com",{"facility":563,"status":64,"city":564,"state":550,"zip":565,"country":68,"countryCode":69,"cosmosGeoPoint":566,"geoPoint":570,"contacts":571},"Pharmacorp Clinical Trials Incorporated","Charleston","29412",{"type":71,"coordinates":567},[568,569],-79.93275,32.77632,{"lat":569,"lon":568},[572],{"name":573,"role":57,"phone":574,"phoneExt":45,"email":575},"Amanda Gibson","8437951710","amandas@pharmacorpclinical.com",{"facility":577,"status":64,"city":578,"state":550,"zip":579,"country":68,"countryCode":69,"cosmosGeoPoint":580,"geoPoint":584,"contacts":585},"Piedmont Research Partners LLC","Fort Mill","29707-4514",{"type":71,"coordinates":581},[582,583],-80.94508,35.00737,{"lat":583,"lon":582},[586],{"name":587,"role":57,"phone":588,"phoneExt":45,"email":589},"Becky Fewell","8038024561","becky@prpstudy.com",{"facility":591,"status":64,"city":592,"state":550,"zip":593,"country":68,"countryCode":69,"cosmosGeoPoint":594,"geoPoint":598,"contacts":599},"Velocity Clinical Research - Gaffney - PPDS","Gaffney","29340-4737",{"type":71,"coordinates":595},[596,597],-81.64982,35.07179,{"lat":597,"lon":596},[600],{"name":601,"role":57,"phone":602,"phoneExt":45,"email":603},"Ashley Rochester","8644881283","arochester@velocityclinical.com",{"facility":605,"status":64,"city":606,"state":550,"zip":607,"country":68,"countryCode":69,"cosmosGeoPoint":608,"geoPoint":612,"contacts":613},"Lowcountry Lung and Critical Care PA","North Charleston","29406",{"type":71,"coordinates":609},[610,611],-79.97481,32.85462,{"lat":611,"lon":610},[614],{"name":615,"role":57,"phone":616,"phoneExt":45,"email":617},"Sharon Moultrie","8435728545","smoultrie@lowcountrylung.com",{"facility":619,"status":64,"city":606,"state":550,"zip":607,"country":68,"countryCode":69,"cosmosGeoPoint":620,"geoPoint":622,"contacts":623},"Monroe Biomedical Research Charleston",{"type":71,"coordinates":621},[610,611],{"lat":611,"lon":610},[624],{"name":625,"role":57,"phone":626,"phoneExt":45,"email":627},"Kristin Gleaton","8434080198","Kristin.gleaton@monroeresearch.com",{"facility":629,"status":64,"city":630,"state":550,"zip":631,"country":68,"countryCode":69,"cosmosGeoPoint":632,"geoPoint":636,"contacts":637},"Clinical Research of Rock Hill","Rock Hill","29732",{"type":71,"coordinates":633},[634,635],-81.02508,34.92487,{"lat":635,"lon":634},[638],{"name":639,"role":57,"phone":640,"phoneExt":45,"email":641},"Caroline B Reynolds","8032519502","creynolds@cresrh.com",{"facility":643,"status":64,"city":644,"state":550,"zip":645,"country":68,"countryCode":69,"cosmosGeoPoint":646,"geoPoint":650,"contacts":651},"Spartanburg Medical Research","Spartanburg","29303-4755",{"type":71,"coordinates":647},[648,649],-81.93205,34.94957,{"lat":649,"lon":648},[652],{"name":653,"role":57,"phone":654,"phoneExt":45,"email":655},"Nicole Crockford","864 5831556","ncrockford@medresearch.com",{"facility":657,"status":64,"city":644,"state":550,"zip":658,"country":68,"countryCode":69,"cosmosGeoPoint":659,"geoPoint":661,"contacts":662},"Velocity Clinical Research","29303",{"type":71,"coordinates":660},[648,649],{"lat":649,"lon":648},[663],{"name":664,"role":57,"phone":665,"phoneExt":45,"email":666},"Meredith Benfield","8644271172","mbenfield@velocityclinical.com",{"facility":668,"status":64,"city":669,"state":550,"zip":670,"country":68,"countryCode":69,"cosmosGeoPoint":671,"geoPoint":675,"contacts":676},"Velocity Clinical Research - Union - PPDS","Union","29379",{"type":71,"coordinates":672},[673,674],-81.62371,34.71541,{"lat":674,"lon":673},[677],{"name":664,"role":57,"phone":665,"phoneExt":45,"email":666},{"facility":679,"status":64,"city":680,"state":681,"zip":682,"country":68,"countryCode":69,"cosmosGeoPoint":683,"geoPoint":687,"contacts":688},"Chattanooga Research & Medicine, PLLC","Chattanooga","Tennessee","37404",{"type":71,"coordinates":684},[685,686],-85.30968,35.04563,{"lat":686,"lon":685},[689],{"name":690,"role":57,"phone":691,"phoneExt":45,"email":692},"Jessica Carroll","4236432253","JCarroll@epbfi.com",{"facility":694,"status":64,"city":680,"state":681,"zip":695,"country":68,"countryCode":69,"cosmosGeoPoint":696,"geoPoint":698,"contacts":699},"ClinSearch - Chattanooga","37421",{"type":71,"coordinates":697},[685,686],{"lat":686,"lon":685},[700],{"name":701,"role":57,"phone":702,"phoneExt":45,"email":703},"Seth Rogers","4236984584","srogers@wakeresearch.com",{"facility":705,"status":64,"city":706,"state":681,"zip":707,"country":68,"countryCode":69,"cosmosGeoPoint":708,"geoPoint":712,"contacts":713},"Clinical Trials Center of Middle Tennessee","Franklin","37067-5665",{"type":71,"coordinates":709},[710,711],-86.86889,35.92506,{"lat":711,"lon":710},[714],{"name":715,"role":57,"phone":716,"phoneExt":45,"email":717},"Erica Scaramuzza","6152058350","escaramuzza@ctcmidtn.com",{"facility":719,"status":720,"city":721,"state":681,"zip":722,"country":68,"countryCode":69,"cosmosGeoPoint":723,"geoPoint":727,"contacts":45},"MultiSpecialty Clinical Research, Inc","COMPLETED","Johnson City","37604",{"type":71,"coordinates":724},[725,726],-82.35347,36.31344,{"lat":726,"lon":725},{"facility":729,"status":64,"city":730,"state":731,"zip":732,"country":68,"countryCode":69,"cosmosGeoPoint":733,"geoPoint":737,"contacts":738},"Inquest Clinical Research","Baytown","Texas","77521",{"type":71,"coordinates":734},[735,736],-94.97743,29.7355,{"lat":736,"lon":735},[739],{"name":740,"role":57,"phone":741,"phoneExt":45,"email":742},"Naheed Mehkri","8326062053","Naheedm2002@yahoo.com",{"facility":744,"status":64,"city":745,"state":731,"zip":746,"country":68,"countryCode":69,"cosmosGeoPoint":747,"geoPoint":751,"contacts":752},"Corsicana Medical Research","Corsicana","75110-2471",{"type":71,"coordinates":748},[749,750],-96.46887,32.09543,{"lat":750,"lon":749},[753],{"name":754,"role":57,"phone":755,"phoneExt":45,"email":756},"Karen Hanna","9038757226","khanna@msacorsicana.com",{"facility":758,"status":64,"city":759,"state":731,"zip":760,"country":68,"countryCode":69,"cosmosGeoPoint":761,"geoPoint":765,"contacts":766},"Horizon CR: Houston Pulmonary Sleep & Allergy Associates - Cypress - ClinEdge - PPDS","Cypress","77429",{"type":71,"coordinates":762},[763,764],-95.69717,29.96911,{"lat":764,"lon":763},[767],{"name":768,"role":57,"phone":769,"phoneExt":45,"email":770},"Lucia Sabido","2815877425","lsabido@horizoncrg.com",{"facility":772,"status":64,"city":773,"state":731,"zip":774,"country":68,"countryCode":69,"cosmosGeoPoint":775,"geoPoint":779,"contacts":780},"Greater Heights Memorial Pulmonary and Sleep","Houston","77008",{"type":71,"coordinates":776},[777,778],-95.36327,29.76328,{"lat":778,"lon":777},[781],{"name":782,"role":57,"phone":783,"phoneExt":45,"email":784},"Lisa Sabido","2818415798","shatabdi@horizoncrg.com",{"facility":786,"status":64,"city":773,"state":731,"zip":787,"country":68,"countryCode":69,"cosmosGeoPoint":788,"geoPoint":790,"contacts":791},"Houston Pulmonary Medicine Associates, PA - Biopharma Informatic - PPDS","77089",{"type":71,"coordinates":789},[777,778],{"lat":778,"lon":777},[792],{"name":793,"role":57,"phone":794,"phoneExt":45,"email":795},"Blanca Guerrero","8328471727","Blanca@biopharmainfo.net",{"facility":797,"status":64,"city":798,"state":731,"zip":799,"country":68,"countryCode":69,"cosmosGeoPoint":800,"geoPoint":804,"contacts":805},"Huntsville Research Institute LLC","Huntsville","77340",{"type":71,"coordinates":801},[802,803],-95.55078,30.72353,{"lat":803,"lon":802},[806],{"name":807,"role":57,"phone":808,"phoneExt":45,"email":809},"Ariana Vazquez","9364394835","Lungclinic06@hotmail.com",{"facility":811,"status":64,"city":812,"state":731,"zip":813,"country":68,"countryCode":69,"cosmosGeoPoint":814,"geoPoint":818,"contacts":819},"Element Research Group","San Antonio","78258",{"type":71,"coordinates":815},[816,817],-98.49363,29.42412,{"lat":817,"lon":816},[820],{"name":821,"role":57,"phone":822,"phoneExt":45,"email":823},"Charles Freeman","2103032007","cfreeman@elementrg.com",{"facility":825,"status":64,"city":826,"state":731,"zip":827,"country":68,"countryCode":69,"cosmosGeoPoint":828,"geoPoint":832,"contacts":833},"Sherman Clinical Research - 403 N. Highland Ave","Sherman","75092",{"type":71,"coordinates":829},[830,831],-96.60888,33.63566,{"lat":831,"lon":830},[834],{"name":835,"role":57,"phone":836,"phoneExt":45,"email":837},"Morgan McCoy","9037714093","morgan@auroraclinicalresearch.com@gmail.com",{"facility":839,"status":64,"city":840,"state":731,"zip":841,"country":68,"countryCode":69,"cosmosGeoPoint":842,"geoPoint":846,"contacts":847},"Tranquil Clinical Research","Webster","77598-4085",{"type":71,"coordinates":843},[844,845],-95.11826,29.53773,{"lat":845,"lon":844},[848],{"name":849,"role":57,"phone":850,"phoneExt":45,"email":851},"James Hamilton","7139076054","JamesH@tranquilityresearch.com",{"type":853,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR","100594205","phase-2-a-phase-iib-ensifentrine-glycopyrrolate-fixed-dose-combination-dose-ranging-study-in-subjects-with-copd-100594205",false,"NCT07016412","A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD","A Phase IIb, Randomized, Double-blind, Placebo- Controlled, Parallel Group Study to Assess the Efficacy and Safety of Ensifentrine-glycopyrrolate Fixed-dose Combination at Two Dose Levels Compared to Glycopyrrolate or Ensifentrine Monotherapy in Subjects With COPD","Inclusion Criteria:\n\n* Males are eligible to participate if they agree to use contraception or abstinence, and refrain from donating fresh unwashed semen during the study and for at least 30 days post-study\n* Females are eligible to participate if they are not pregnant, breastfeeding and if one of the following conditions apply:\n\n  1. Not a woman of child-bearing potential OR\n  2. Agrees to follow the contraceptive guidance from screening throughout the study and for at least 30 days post-study\n  3. Agrees not to donate eggs for the purpose of reproduction from screening throughout the study and for at least 30 days post-study\n* Current of former cigarette smokers with a history of smoking ≥ 10 pack years at the time of signing informed consent \\[number of pack years = (number of cigarettes per day \u002F 20) × number of years smoked (e.g., 20 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years)\\]. Pipe and\u002For cigar use cannot be used to calculate pack-year history. Former smokers are defined as those who have stopped smoking for at least 6 months prior to signing informed consent. Smoking cessation programs are permitted during the study\n* Subjects with an established clinical history of COPD as defined by the American Thoracic Society (ATS)\u002FEuropean Respiratory Society (ERS) guidelines with symptoms compatible with COPD\n* A score of ≥ 2 on the Modified Medical Research Council (mMRC) Dyspnea Scale at the Screening Visit\n* Post-bronchodilator (4 puffs of albuterol) spirometry during the Screening Period demonstrating both the following:\n\n  1. FEV1\u002Fforced vital capacity (FVC) ratio of \\\u003C 0.70 AND\n  2. FEV1 ≥ 30 % and ≤ 70% of predicted normal\n* A posterior-anterior chest x-ray (CXR) during the Screening Period or within 12 months of signing the Informed Consent Form (ICF) showing no clinically significant abnormalities unrelated to COPD. If a CXR within the past 12 months is not available but a computed tomography (CT) scan within the same time period is available, the CT scan may be reviewed in place of a CXR\n* Subjects on no maintenance\u002Fbackground therapy or subjects on stable maintenance as either long-acting β2-agonist (LABA) or long-acting β2-agonist\u002FInhaled corticosteroid (LABA\u002FICS) therapy are eligible. Subjects taking maintenance therapy must demonstrate regular use of maintenance therapy, in any form, for at least 60 days prior to signing informed consent and agree to continue use of their current permitted LABA or LABA\u002FICS medication for the duration of the screening and treatment period\n* Capable of withholding from short-acting bronchodilators for 4 hours prior to spirometry testing. Subjects receiving maintenance therapy with a LABA or LABA\u002FICS must be capable of withholding twice-daily maintenance therapy for 24 hours and once-daily maintenance therapy for 48 hours prior to initiation of any spirometry\n* Capable of using the study jet nebulizer correctly\n* Ability to perform acceptable spirometry in accordance with ATS\u002FERS guidelines\n* Willing and able to attend all study visits and adhere to all study assessments and procedures\n\nExclusion Criteria:\n\n* Concomitant clinically significant pulmonary disease other than COPD (i.e., asthma, tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, interstitial lung diseases, sleep apnea (unless controlled with stable continuous positive airway pressure \\[CPAP\\] use), known alpha-1 antitrypsin deficiency, core pulmonale or other non-specific pulmonary disease\n* Within 6 months prior to randomization, a COPD exacerbation requiring hospitalization\n* Within 3 months prior to randomization, use of oral or systemic therapies for COPD exacerbations (for example, oral, intravenous, or intramuscular glucocorticoids, antibiotics, theophylline, and roflumilast)\n* History of life-threatening COPD, including Intensive Care Unit admission and\u002For requiring intubation\n* Severe comorbidities including\n\n  1. unstable cardiac disease (myocardial infarction within 1 year prior to randomization, unstable angina within 6 months prior to randomization, unstable or life-threatening arrhythmia requiring intervention within 3 months prior to randomization, diagnosis of New York Heart Association (NYHA) class III or IV heart disease, or\n  2. any other clinically significant medical conditions including uncontrolled diseases (e.g., endocrine, neurological, hepatic, gastrointestinal, renal, hematological, urological, immunological, psychiatric \\[e.g. untreated significant depression, anxiety or history of suicidality\\], or ophthalmic diseases) that would, in the opinion of the Investigator, preclude the subject from safely completing the required tests or the study, or is likely to result in disease progression that would require withdrawal of the subject\n* History of or clinically significant on-going bladder outflow obstruction or history of catheterization for relief of bladder outflow obstruction within 6 months prior to randomization\n* History of narrow angle glaucoma\n* History of hypersensitivity or intolerance to aerosol medications, albuterol, ensifentrine, or glycopyrrolate or any of its excipients\u002Fcomponents, anticholinergic agents, or sympathomimetic amines\n* History of or current malignancy of any organ system, treated or untreated within the 5 years prior to randomization, except for localized basal or squamous cell carcinoma of the skin\n* Other significant psychiatric disease that would likely result in the subject not being able to complete the study, in the opinion of the Investigator\n* Findings on physical examination that an investigator considers to be clinically significant or abnormal during the Screening Period including hematology, biochemistry, viral serology, and ECG\n* Prior or current use of Ohtuvayre (ensifentrine)\n* Previous lung resection or lung reduction surgery within 1-year of randomization\n* Long term oxygen use defined as oxygen therapy prescribed for greater than 12 hours per day. As needed oxygen use (≤ 12 hours per day) is not exclusionary\n* Pulmonary rehabilitation unless such treatment has been stable from 4 weeks prior to signing the ICF and plans to remain stable during the study. Pulmonary rehabilitation programs should not be started or completed during participation in the study\n* Major surgery (requiring general anesthesia) in the 6 weeks prior randomization, lack of full recovery from surgery at randomization, or planned surgery through the end of the study\n* Current or history of drug or alcohol abuse within the 5 years prior to randomization\n* Estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin as tested during the Screening Period\n* Alanine aminotransferase (ALT) ≥ 2 × upper limit of normal (ULN), aspartate aminotransferase (AST) ≥ 2 × ULN, alkaline phosphatase and\u002For total bilirubin \\> 1.5 × ULN (subjects with Gilbert's syndrome can be included with total bilirubin \\>1.5 × ULN as long as direct bilirubin is ≤ 1.5 × ULN)\n* Use of an experimental drug within 30 days or 5 half-lives of signing the ICF, whichever is longer, and\u002For participation in a study treatment-free follow-up phase of a clinical study within 30 days prior to signing the ICF\n* Use of an experimental medical device or participation in a follow-up phase of an experimental medical device clinical study within 30 days prior to informed consent\n* Affiliation with the investigator site, including an Investigator, Sub-Investigator, study coordinator, study nurse, other employee of participating investigator or study site or a family member of the aforementioned","ALL","40 Years","80 Years",{"count":865,"type":866},480,"ESTIMATED","INTERVENTIONAL",[869],"PHASE2","This study will assess the safety and efficacy of fixed dose combinations of ensifentrine with two different glycopyrrolate dose levels compared to placebo and to the individual components of the fixed dose combinations, each administered twice a day via standard jet nebulizer, in adult subjects with chronic obstructive pulmonary disease (COPD).",[872],"Chronic Obstructive Pulmonary Disease",[872,874,875,876],"COPD","bronchodilator","ensifentrine-glycopyrrolate","2026-06-01",{"date":879,"type":880},"2026-06-03","ACTUAL",{"date":882,"type":880},"2025-07-31",{"date":884,"type":866},"2026-08-05",{"name":5,"class":6},57]