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Adult male or female ≥18 years (or country's legal age of adulthood)\n2. A diagnosis of MASH with Fibrosis (F) stage 2 or 3, according to the NASH-CRN\n3. NAS score ≥3, as defined in the protocol\n4. Meets genotype criteria for study enrollment, as defined in the protocol\n5. Has a protocol defined FibroScan®-AST (FAST) score at screening or within approximately 12 weeks of screening\n\nKey Exclusion Criteria:\n\n1. Evidence of other forms of known chronic liver disease, as defined in the protocol\n2. Known history of alcohol or other substance abuse within the last year or at any time during screening, as defined in the protocol\n3. History of Type 1 diabetes\n4. Bariatric surgery within approximately 5 years prior to or planned during the study period\n5. Prior exposure to any investigational drug targeting HSD17B13 or patatin-like phospholipase domain containing 3 (PNPLA3) (eg, ALN-HSD, ARO-HSD, ALN-PNP, AZD2693)\n\nNote: Other protocol-defined Inclusion\u002FExclusion Criteria apply","ALL","18 Years","75 Years",{"count":667,"type":668},120,"ESTIMATED","INTERVENTIONAL",[671],"PHASE2","This study is researching an investigational drug, ALN-HSD called \"study drug\". This study is focused on participants who are known to have Metabolic dysfunction-Associated SteatoHepatitis (MASH). MASH is a form of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). MASH occurs when fat builds up in liver cells, damaging them, and making the liver inflamed and stiff from fibrosis (scar tissue). MASH can progress to cirrhosis (long term scarring) and liver failure (when the liver cannot perform its job). The aim of the study is to see the effect of the study drug on lessening liver scarring related to MASH.\n\nThe study is looking at several other research questions, including:\n\n* How ALN-HSD works to improve liver function and lessen MASH-related inflammation in the liver\n* What side effects may happen from receiving the study drug\n* How much study drug and study drug metabolites (byproduct of the body breaking down the study drug) are in the blood at different times\n* Better understanding of the study drug and MASH",[674],"Metabolic Dysfunction-Associated SteatoHepatitis (MASH)",[676,677,678,679],"Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD)","Histologically confirmed MASH","Genetic risk alleles for MASH at the HSD17B13 locus","Non-Alcoholic SteatoHepatitis (NASH)","2026-05-18",{"date":682,"type":683},"2026-05-19","ACTUAL",{"date":685,"type":683},"2023-02-09",{"date":687,"type":668},"2028-12-07",{"name":5,"class":6},71]