[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612149":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":69,"collaborators":30,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":30,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":30,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":52,"whyStopped":30,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"0.67 mcg\u002Fkg","EXPERIMENTAL","Addition of dexmedetomidine 0.67 mcg\u002Fkg to local anesthetics in infraclavicular brachial plexus block",[13],"Drug: dexmedetomidine (perineural) 0.67 mcg\u002Fkg",{"label":15,"type":10,"description":16,"interventionNames":17},"1 mcg\u002Fkg","Addition of dexmedetomidine 1 mcg\u002Fkg to local anesthetics in infraclavicular brachial plexus block",[18],"Drug: dexmedetomidine (perineural) 1 mcg\u002Fkg",{"label":20,"type":10,"description":21,"interventionNames":22},"1.33 mcg\u002Fkg","Addition of dexmedetomidine 1.33 mcg\u002Fkg to local anesthetics in infraclavicular brachial plexus block",[23],"Drug: dexmedetomidine (perineural) 1.33 mcg\u002Fkg",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","dexmedetomidine (perineural) 0.67 mcg\u002Fkg","Perineural dexmedetomidine 0.67 mcg\u002Fkg will be added to the local anesthetic used to block the cords of the brachial plexus with an infraclavicular approach.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"dexmedetomidine (perineural) 1 mcg\u002Fkg","Perineural dexmedetomidine 1 mcg\u002Fkg will be added to the local anesthetic used to block the cords of the brachial plexus with an infraclavicular approach.",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"dexmedetomidine (perineural) 1.33 mcg\u002Fkg","Perineural dexmedetomidine 1.33 mcg\u002Fkg will be added to the local anesthetic used to block the cords of the brachial plexus with an infraclavicular approach.",[20],[40],{"name":41,"affiliation":5,"role":42},"Julián Aliste, MD","PRINCIPAL_INVESTIGATOR",[44],{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","514-934-1934","43261","julian.aliste@mcgill.ca",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"McGill University Health Centre","RECRUITING","Montreal","Quebec","H3G 1A4","Canada","CA",{"type":59,"coordinates":60},"Point",[61,62],-73.58781,45.50884,{"lat":62,"lon":61},[65],{"name":66,"role":45,"phone":67,"phoneExt":30,"email":68},"Samita Pirotesak, M.D.","4384067337","s.pirotesak@gmail.com",{"type":42,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Julián Aliste","Associate Professor","100612149","phase-2-a-randomized-comparison-between-067-mcgkg-1-mcgkg-and-133-mcgkg-of-perineural-dexmedetomidine-for-ultrasound-guided-infraclavicular-block-100612149",false,"NCT07249827","A Randomized Comparison Between 0.67 mcg\u002Fkg, 1 mcg\u002Fkg, and 1.33 mcg\u002Fkg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block","Inclusion Criteria:\n\n* patients undergoing upper limb surgery at or below the elbow\n* age between 18 and 75 years\n* American Society of Anesthesiologists classification 1-3\n* body mass index between 18 and 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* adults who are unable to give their own consent\n* allergy or contraindication to dexmedetomidine\n* exposure to dexmedetomidine during the previous 48 hrs\n* pre-existing neuropathy (assessed by history and physical examination)\n* coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood workup i.e. platelets ≤ 100, International Normalized Ratio ≥ 1.4 or partial prothrombin time ≥ 50)\n* renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. creatinine. eGFR \\\u003C 90)\n* hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. transaminases ≥ 100)\n* allergy to LA\n* pregnancy (as institutional policy, female patients with childbearing potential undergoing non urgent surgery are tested preoperatively for pregnancy with blood tests)\n* breast feeding\n* prior surgery in the infraclavicular region\n* chronic pain syndromes requiring opioid intake at home","ALL","18 Years","75 Years",{"count":82,"type":83},69,"ESTIMATED","INTERVENTIONAL",[86],"PHASE2","This study will compare three different doses of perineural dexmedetomidine 0.67 mcg\u002Fkg, 1 mcg\u002Fkg, and 1.33 mcg\u002Fkg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Our research hypothesis is that 1.33 mcg\u002Fkg will provide a 15%-longer duration than 1mcg\u002Fkg, which in turn will provide a 15%-longer duration than 0.67 mcg\u002Fkg. Since analgesic duration and sensory duration can be influenced by intake of pain medications and surgical trauma to small cutaneous nerves, respectively, we will select motor block duration as the main outcome to better target the action of dexmedetomidine on the brachial plexus.",[89,90,91,92],"Analgesia","Pain, Acute","Upper Extremity Surgery","Nerve Block",[89,94,95,96,97,98],"Acute pain","Brachial plexus","Brachial plexus block","Postoperative pain","Nerve block","2026-01-04",{"date":101,"type":102},"2026-01-07","ACTUAL",{"date":104,"type":102},"2025-12-28",{"date":106,"type":83},"2026-06-30",{"name":5,"class":6},1]