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status (PS) 0 or 1.\n* Life expectancy of \\> 6 months as estimated by the Investigator.\n\nKey Exclusion Criteria:\n\n* Any exposure to immune checkpoint inhibitor (ICIs) since the time of first being diagnosed with uveal melanoma.\n* Known acute or chronic Hepatitis B or C infection or human immunodeficiency virus (HIV) infection or any other uncontrolled infection.\n* Current active significant herpetic infections or prior complications of HSV-1 infection.\n* Any central nervous system (CNS) involvement of melanoma, including carcinomatous meningitis.\n* Major surgery ≤ 2 weeks prior to the first dose of study intervention.\n* Any bleeding, thrombotic and\u002For other event that places the patient at an unacceptable risk of complications of intratumoral therapy.\n* Active, known, or suspected autoimmune disease requiring systemic treatment.\n* Prior treatment with an oncolytic virus.\n* Requires intermittent or chronic use of systemic (oral or IV) antivirals with known antiherpetic 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