[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602831":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":11,"centralContacts":56,"locations":62,"responsibleParty":365,"collaborators":11,"id":367,"slug":368,"hasResults":369,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":11,"eligibilityCriteria":373,"healthyVolunteers":369,"sex":374,"minAge":375,"maxAge":11,"enrollmentInfo":376,"targetDuration":11,"studyType":379,"phases":380,"briefSummary":372,"conditions":382,"keywords":11,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":393},{"fullName":5,"class":6},"Bausch & Lomb Incorporated","INDUSTRY",[8,14,19,23,28,31],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1","EXPERIMENTAL",null,[13],"Drug: Lifitegrast\u002FPerfluorohexyloctane Fixed Dose Combination",{"label":15,"type":16,"description":11,"interventionNames":17},"Arm 2","ACTIVE_COMPARATOR",[18],"Drug: Lifitegrast",{"label":20,"type":16,"description":11,"interventionNames":21},"Arm 3",[22],"Drug: Perfluorohexyloctane",{"label":24,"type":25,"description":11,"interventionNames":26},"Arm 4","PLACEBO_COMPARATOR",[27],"Drug: Vehicle",{"label":29,"type":25,"description":11,"interventionNames":30},"Arm 5",[27],{"label":32,"type":25,"description":11,"interventionNames":33},"Arm 6",[27],[35,40,44,48,52,54],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":11},"DRUG","Lifitegrast\u002FPerfluorohexyloctane Fixed Dose Combination","Topical ocular drop of lifitegrast and perfluorohexyloctane administered for 4 weeks",[9],{"type":36,"name":41,"description":42,"armGroupLabels":43,"otherNames":11},"Lifitegrast","Topical ocular drop of lifitegrast administered for 4 weeks",[15],{"type":36,"name":45,"description":46,"armGroupLabels":47,"otherNames":11},"Perfluorohexyloctane","Topical ocular drop of perfluorohexyloctane administered for 4 weeks",[20],{"type":36,"name":49,"description":50,"armGroupLabels":51,"otherNames":11},"Vehicle","Topical ocular drop with no active ingredients administered for 4 weeks",[24],{"type":36,"name":49,"description":50,"armGroupLabels":53,"otherNames":11},[29],{"type":36,"name":49,"description":50,"armGroupLabels":55,"otherNames":11},[32],[57],{"name":58,"role":59,"phone":60,"phoneExt":11,"email":61},"Study Manager Bausch and Lomb","CONTACT","2147262850","BLCTgovcentral@bausch.com",[63,77,87,96,105,114,123,133,142,151,161,171,181,191,200,210,216,225,234,244,253,263,272,281,291,301,311,321,331,337,346,356],{"facility":64,"status":65,"city":66,"state":67,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":11},"Eye Doctors of Arizona, PLLC","RECRUITING","Phoenix","Arizona","85028","United States","US",{"type":72,"coordinates":73},"Point",[74,75],-112.07404,33.44838,{"lat":75,"lon":74},{"facility":78,"status":65,"city":79,"state":80,"zip":81,"country":69,"countryCode":70,"cosmosGeoPoint":82,"geoPoint":86,"contacts":11},"Global Research Management, Inc.","Glendale","California","91204",{"type":72,"coordinates":83},[84,85],-118.25508,34.14251,{"lat":85,"lon":84},{"facility":88,"status":65,"city":89,"state":80,"zip":90,"country":69,"countryCode":70,"cosmosGeoPoint":91,"geoPoint":95,"contacts":11},"SoCal Eye - Lakewood Clinic","Long Beach","90805",{"type":72,"coordinates":92},[93,94],-118.18923,33.76696,{"lat":94,"lon":93},{"facility":97,"status":65,"city":98,"state":80,"zip":99,"country":69,"countryCode":70,"cosmosGeoPoint":100,"geoPoint":104,"contacts":11},"LoBue Laser and Eye Medical Center","Murrieta","92562",{"type":72,"coordinates":101},[102,103],-117.21392,33.55391,{"lat":103,"lon":102},{"facility":106,"status":65,"city":107,"state":80,"zip":108,"country":69,"countryCode":70,"cosmosGeoPoint":109,"geoPoint":113,"contacts":11},"Eye Research Foundation, Inc.","Newport Beach","92663",{"type":72,"coordinates":110},[111,112],-117.92895,33.61891,{"lat":112,"lon":111},{"facility":115,"status":65,"city":116,"state":80,"zip":117,"country":69,"countryCode":70,"cosmosGeoPoint":118,"geoPoint":122,"contacts":11},"Wolstan and Goldberg Eye Associates","Torrance","90505",{"type":72,"coordinates":119},[120,121],-118.34063,33.83585,{"lat":121,"lon":120},{"facility":124,"status":65,"city":125,"state":126,"zip":127,"country":69,"countryCode":70,"cosmosGeoPoint":128,"geoPoint":132,"contacts":11},"Segal Drug Trials\u002FOffice of Bruce A Segal, MD","Delray Beach","Florida","33484",{"type":72,"coordinates":129},[130,131],-80.07282,26.46146,{"lat":131,"lon":130},{"facility":134,"status":65,"city":135,"state":126,"zip":136,"country":69,"countryCode":70,"cosmosGeoPoint":137,"geoPoint":141,"contacts":11},"Bowden Eye and Associates","Jacksonville","32256",{"type":72,"coordinates":138},[139,140],-81.65565,30.33218,{"lat":140,"lon":139},{"facility":143,"status":65,"city":144,"state":126,"zip":145,"country":69,"countryCode":70,"cosmosGeoPoint":146,"geoPoint":150,"contacts":11},"Shettle Eye Research, Inc","Largo","33773",{"type":72,"coordinates":147},[148,149],-82.78842,27.90979,{"lat":149,"lon":148},{"facility":152,"status":65,"city":153,"state":154,"zip":155,"country":69,"countryCode":70,"cosmosGeoPoint":156,"geoPoint":160,"contacts":11},"Clayton Eye Clinical Research, LLC","Morrow","Georgia","30260",{"type":72,"coordinates":157},[158,159],-84.33937,33.58317,{"lat":159,"lon":158},{"facility":162,"status":65,"city":163,"state":164,"zip":165,"country":69,"countryCode":70,"cosmosGeoPoint":166,"geoPoint":170,"contacts":11},"Midwest Cornea Associates LLC","Carmel","Indiana","46032",{"type":72,"coordinates":167},[168,169],-86.11804,39.97837,{"lat":169,"lon":168},{"facility":172,"status":65,"city":173,"state":174,"zip":175,"country":69,"countryCode":70,"cosmosGeoPoint":176,"geoPoint":180,"contacts":11},"Kannarr Eye Care, LLC","Pittsburg","Kansas","66762",{"type":72,"coordinates":177},[178,179],-94.70496,37.41088,{"lat":179,"lon":178},{"facility":182,"status":65,"city":183,"state":184,"zip":185,"country":69,"countryCode":70,"cosmosGeoPoint":186,"geoPoint":190,"contacts":11},"Vance Thompson Vision - Alexandria","Alexandria","Minnesota","56308",{"type":72,"coordinates":187},[188,189],-95.37754,45.88524,{"lat":189,"lon":188},{"facility":192,"status":65,"city":193,"state":184,"zip":194,"country":69,"countryCode":70,"cosmosGeoPoint":195,"geoPoint":199,"contacts":11},"Complete Eye Care of Medina","Medina","55340",{"type":72,"coordinates":196},[197,198],-93.58246,45.03524,{"lat":198,"lon":197},{"facility":201,"status":65,"city":202,"state":203,"zip":204,"country":69,"countryCode":70,"cosmosGeoPoint":205,"geoPoint":209,"contacts":11},"Insight Eyecare Specialties, Inc.","Kansas City","Missouri","64111",{"type":72,"coordinates":206},[207,208],-94.57857,39.09973,{"lat":208,"lon":207},{"facility":211,"status":65,"city":202,"state":203,"zip":212,"country":69,"countryCode":70,"cosmosGeoPoint":213,"geoPoint":215,"contacts":11},"Moyes Eye Center, P.C.","64154",{"type":72,"coordinates":214},[207,208],{"lat":208,"lon":207},{"facility":217,"status":65,"city":218,"state":203,"zip":219,"country":69,"countryCode":70,"cosmosGeoPoint":220,"geoPoint":224,"contacts":11},"Ophthalmology Consultants, Ltd.","St Louis","63131",{"type":72,"coordinates":221},[222,223],-90.19789,38.62727,{"lat":223,"lon":222},{"facility":226,"status":65,"city":227,"state":203,"zip":228,"country":69,"countryCode":70,"cosmosGeoPoint":229,"geoPoint":233,"contacts":11},"Comprehensive Eye Care Ltd.","Washington","63090",{"type":72,"coordinates":230},[231,232],-91.01209,38.55811,{"lat":232,"lon":231},{"facility":235,"status":65,"city":236,"state":237,"zip":238,"country":69,"countryCode":70,"cosmosGeoPoint":239,"geoPoint":243,"contacts":11},"Opthalmic consultants of Long Island","Garden City","New York","11530",{"type":72,"coordinates":240},[241,242],-73.6343,40.72677,{"lat":242,"lon":241},{"facility":245,"status":65,"city":246,"state":237,"zip":247,"country":69,"countryCode":70,"cosmosGeoPoint":248,"geoPoint":252,"contacts":11},"Rochester Ophthalmological Group,PC","Rochester","14618",{"type":72,"coordinates":249},[250,251],-77.61556,43.15478,{"lat":251,"lon":250},{"facility":254,"status":65,"city":255,"state":256,"zip":257,"country":69,"countryCode":70,"cosmosGeoPoint":258,"geoPoint":262,"contacts":11},"Asheville Eye Associates","Asheville","North Carolina","28803",{"type":72,"coordinates":259},[260,261],-82.55402,35.60095,{"lat":261,"lon":260},{"facility":264,"status":65,"city":265,"state":256,"zip":266,"country":69,"countryCode":70,"cosmosGeoPoint":267,"geoPoint":271,"contacts":11},"Oculus Research","Garner","27529",{"type":72,"coordinates":268},[269,270],-78.61417,35.71126,{"lat":270,"lon":269},{"facility":273,"status":65,"city":274,"state":256,"zip":275,"country":69,"countryCode":70,"cosmosGeoPoint":276,"geoPoint":280,"contacts":11},"CORE Inc.","Shelby","28150",{"type":72,"coordinates":277},[278,279],-81.53565,35.29235,{"lat":279,"lon":278},{"facility":282,"status":65,"city":283,"state":284,"zip":285,"country":69,"countryCode":70,"cosmosGeoPoint":286,"geoPoint":290,"contacts":11},"Vance Thompson Vision - Fargo, ND","West Fargo","North Dakota","58078",{"type":72,"coordinates":287},[288,289],-96.90036,46.87497,{"lat":289,"lon":288},{"facility":292,"status":65,"city":293,"state":294,"zip":295,"country":69,"countryCode":70,"cosmosGeoPoint":296,"geoPoint":300,"contacts":11},"Insight Research Clinic LLC.","Powell","Ohio","43065",{"type":72,"coordinates":297},[298,299],-83.07519,40.15784,{"lat":299,"lon":298},{"facility":302,"status":65,"city":303,"state":304,"zip":305,"country":69,"countryCode":70,"cosmosGeoPoint":306,"geoPoint":310,"contacts":11},"Scott & Christie Eyecare Associates - The Surgery Center at Cranberry","Cranberry Township","Pennsylvania","16066",{"type":72,"coordinates":307},[308,309],-80.10714,40.68496,{"lat":309,"lon":308},{"facility":312,"status":65,"city":313,"state":314,"zip":315,"country":69,"countryCode":70,"cosmosGeoPoint":316,"geoPoint":320,"contacts":11},"West Bay Eye Associates","Warwick","Rhode Island","02888",{"type":72,"coordinates":317},[318,319],-71.41617,41.7001,{"lat":319,"lon":318},{"facility":322,"status":65,"city":323,"state":324,"zip":325,"country":69,"countryCode":70,"cosmosGeoPoint":326,"geoPoint":330,"contacts":11},"Southern College of Optometry","Memphis","Tennessee","38104",{"type":72,"coordinates":327},[328,329],-90.04898,35.14953,{"lat":329,"lon":328},{"facility":332,"status":65,"city":323,"state":324,"zip":333,"country":69,"countryCode":70,"cosmosGeoPoint":334,"geoPoint":336,"contacts":11},"Total Eye Care PA","38119",{"type":72,"coordinates":335},[328,329],{"lat":329,"lon":328},{"facility":338,"status":65,"city":339,"state":324,"zip":340,"country":69,"countryCode":70,"cosmosGeoPoint":341,"geoPoint":345,"contacts":11},"Advancing Vision Research, LLC","Smyrna","37167",{"type":72,"coordinates":342},[343,344],-86.5186,35.98284,{"lat":344,"lon":343},{"facility":347,"status":65,"city":348,"state":349,"zip":350,"country":69,"countryCode":70,"cosmosGeoPoint":351,"geoPoint":355,"contacts":11},"Intouch Clinical Research Center","Houston","Texas","77034",{"type":72,"coordinates":352},[353,354],-95.36327,29.76328,{"lat":354,"lon":353},{"facility":357,"status":65,"city":358,"state":349,"zip":359,"country":69,"countryCode":70,"cosmosGeoPoint":360,"geoPoint":364,"contacts":11},"Lake Travis Eye and Laser Center","Lakeway","78738",{"type":72,"coordinates":361},[362,363],-97.97959,30.36377,{"lat":363,"lon":362},{"type":366,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100602831","phase-2-a-study-evaluating-the-safety-and-efficacy-of-a-fixed-dose-combination-for-dry-eye-disease-100602831",false,"NCT07128628","A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease","A 4-Week, Randomized, Double-Masked, Parallel-Group, Active-Controlled, Multicenter Study Evaluating Lifitegrast\u002FPerfluorohexyloctane Fixed-Dose Combination Administered Twice Daily on Signs and Symptoms of Dry Eye Disease","Inclusion Criteria:\n\nThis study will include subjects who meet all of the following inclusion criteria:\n\n* Voluntarily provide written informed consent\n* ≥18 years of age\n* Subject-reported history of DED OU for at least 6 months\n* Same eye satisfies the criteria for dry eye signs at both screening and baseline\u002Frandomization\n* The criteria for dry eye symptoms are met at both screening and baseline\u002Frandomization\n* As needed (PRN) or scheduled use of non-prescription (OTC) artificial tear, gels, or lubricants for symptoms of dry eye within the past 30 days\n* Able and willing to follow instructions, including participation in all trial assessments and visits\n\nExclusion Criteria:\n\nThis study will exclude subjects who meet any of the following exclusion criteria (Note: Ocular exclusion criteria are relevant to both eyes, such that meeting a criterion in either eye excludes the subject from the study):\n\n* Known allergy or sensitivity to any study treatment (or any of its components)\n* Best-corrected visual acuity (BCVA) of 0.7 logarithm of the minimum angle of resolution (logMAR) or worse (50 Early Treatment Diabetic Retinopathy Study \\[ETDRS\\] letters; Snellen equivalent score of 20\u002F100 or worse) at Visit 1 (Screening) or Visit 2 (baseline\u002Frandomization)\n* Any clinically significant (CS) ocular surface slit-lamp findings at Visit 1 (Screening) or Visit 2 (baseline\u002Frandomization), or findings that may interfere with trial parameters in the opinion of the Investigator.\n* Use of any of any ocular therapies within 30 days.\n* Unable or unwilling to stop current topical dry eye treatments\n\nAdditional criteria per protocol","ALL","18 Years",{"count":377,"type":378},423,"ESTIMATED","INTERVENTIONAL",[381],"PHASE2",[383],"Dry Eye Disease","2026-03-11",{"date":386,"type":387},"2026-03-13","ACTUAL",{"date":389,"type":387},"2025-10-24",{"date":391,"type":378},"2026-11",{"name":5,"class":6},32]