[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523424":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":33,"responsibleParty":321,"collaborators":31,"id":323,"slug":324,"hasResults":325,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":325,"sex":331,"minAge":332,"maxAge":31,"enrollmentInfo":333,"targetDuration":31,"studyType":336,"phases":337,"briefSummary":339,"conditions":340,"keywords":342,"overallStatus":36,"whyStopped":31,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":353},{"fullName":5,"class":6},"Puma Biotechnology, Inc.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Alisertib","EXPERIMENTAL","50 mg (Prior to Amendment 2) or 60 mg (Amendment 2) or 70 mg (Amendment 3 or later) of alisertib PO BID on days 1-7 of each 21-day cycle",[13],"Drug: Alisertib",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Alisertib enteric-coated tablets",[9],[20,21],"PB-8237","MLN8237",[23],{"name":24,"affiliation":5,"role":25},"Chief Scientific Officer","STUDY_DIRECTOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Puma Biotechnology, Inc. Clinical Operations Senior Director","CONTACT","(424) 248-6500",null,"ClinicalTrials@pumabiotechnology.com",[34,48,58,68,78,88,96,105,115,125,135,145,150,160,170,180,190,199,206,215,225,236,246,256,266,272,282,292,301,311],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":31},"Southern Cancer Center","RECRUITING","Daphne","Alabama","36526","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-87.9036,30.60353,{"lat":46,"lon":45},{"facility":49,"status":36,"city":50,"state":51,"zip":52,"country":40,"countryCode":41,"cosmosGeoPoint":53,"geoPoint":57,"contacts":31},"The Oncology Institute of Hope and Innovation","Long Beach","California","90805",{"type":43,"coordinates":54},[55,56],-118.18923,33.76696,{"lat":56,"lon":55},{"facility":59,"status":36,"city":60,"state":61,"zip":62,"country":40,"countryCode":41,"cosmosGeoPoint":63,"geoPoint":67,"contacts":31},"Rocky Mountain Cancer Centers","Lone Tree","Colorado","80124",{"type":43,"coordinates":64},[65,66],-104.8863,39.55171,{"lat":66,"lon":65},{"facility":69,"status":36,"city":70,"state":71,"zip":72,"country":40,"countryCode":41,"cosmosGeoPoint":73,"geoPoint":77,"contacts":31},"Georgetown Lombardi Cancer Center","Washington D.C.","District of Columbia","20057",{"type":43,"coordinates":74},[75,76],-77.03637,38.89511,{"lat":76,"lon":75},{"facility":79,"status":36,"city":80,"state":81,"zip":82,"country":40,"countryCode":41,"cosmosGeoPoint":83,"geoPoint":87,"contacts":31},"Clermont Oncology Center","Clermont","Florida","64711",{"type":43,"coordinates":84},[85,86],-81.77285,28.54944,{"lat":86,"lon":85},{"facility":49,"status":36,"city":89,"state":81,"zip":90,"country":40,"countryCode":41,"cosmosGeoPoint":91,"geoPoint":95,"contacts":31},"Fort Lauderdale","33316",{"type":43,"coordinates":92},[93,94],-80.14338,26.12231,{"lat":94,"lon":93},{"facility":97,"status":36,"city":98,"state":81,"zip":99,"country":40,"countryCode":41,"cosmosGeoPoint":100,"geoPoint":104,"contacts":31},"Moffitt Cancer Center","Tampa","33612",{"type":43,"coordinates":101},[102,103],-82.45843,27.94752,{"lat":103,"lon":102},{"facility":106,"status":36,"city":107,"state":108,"zip":109,"country":40,"countryCode":41,"cosmosGeoPoint":110,"geoPoint":114,"contacts":31},"Illinois Cancer Specialists","Niles","Illinois","60714",{"type":43,"coordinates":111},[112,113],-87.80284,42.01892,{"lat":113,"lon":112},{"facility":116,"status":36,"city":117,"state":118,"zip":119,"country":40,"countryCode":41,"cosmosGeoPoint":120,"geoPoint":124,"contacts":31},"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","Indianapolis","Indiana","46202",{"type":43,"coordinates":121},[122,123],-86.15804,39.76838,{"lat":123,"lon":122},{"facility":126,"status":36,"city":127,"state":128,"zip":129,"country":40,"countryCode":41,"cosmosGeoPoint":130,"geoPoint":134,"contacts":31},"University of Maryland Greenebaum Comprehensive Cancer Center","Baltimore","Maryland","21201",{"type":43,"coordinates":131},[132,133],-76.61219,39.29038,{"lat":133,"lon":132},{"facility":136,"status":36,"city":137,"state":138,"zip":139,"country":40,"countryCode":41,"cosmosGeoPoint":140,"geoPoint":144,"contacts":31},"Beth Israel Deaconess Medical Center","Boston","Massachusetts","02215",{"type":43,"coordinates":141},[142,143],-71.05977,42.35843,{"lat":143,"lon":142},{"facility":146,"status":36,"city":137,"state":138,"zip":139,"country":40,"countryCode":41,"cosmosGeoPoint":147,"geoPoint":149,"contacts":31},"Dana Farber Cancer Institute",{"type":43,"coordinates":148},[142,143],{"lat":143,"lon":142},{"facility":151,"status":36,"city":152,"state":153,"zip":154,"country":40,"countryCode":41,"cosmosGeoPoint":155,"geoPoint":159,"contacts":31},"Henry Ford Hospital","Detroit","Michigan","48202",{"type":43,"coordinates":156},[157,158],-83.04575,42.33143,{"lat":158,"lon":157},{"facility":161,"status":36,"city":162,"state":163,"zip":164,"country":40,"countryCode":41,"cosmosGeoPoint":165,"geoPoint":169,"contacts":31},"Minnesota Oncology Hematology","Burnsville","Minnesota","55337",{"type":43,"coordinates":166},[167,168],-93.27772,44.76774,{"lat":168,"lon":167},{"facility":171,"status":36,"city":172,"state":173,"zip":174,"country":40,"countryCode":41,"cosmosGeoPoint":175,"geoPoint":179,"contacts":31},"Nebraska Cancer Specialists","Grand Island","Nebraska","68803",{"type":43,"coordinates":176},[177,178],-98.34201,40.92501,{"lat":178,"lon":177},{"facility":181,"status":36,"city":182,"state":183,"zip":184,"country":40,"countryCode":41,"cosmosGeoPoint":185,"geoPoint":189,"contacts":31},"Oncology Hematology Care Clinical Trials","Cincinnati","Ohio","45226",{"type":43,"coordinates":186},[187,188],-84.51439,39.12711,{"lat":188,"lon":187},{"facility":191,"status":36,"city":192,"state":183,"zip":193,"country":40,"countryCode":41,"cosmosGeoPoint":194,"geoPoint":198,"contacts":31},"University Hospital - Cleveland Medical Center","Cleveland","44106",{"type":43,"coordinates":195},[196,197],-81.69541,41.4995,{"lat":197,"lon":196},{"facility":200,"status":201,"city":192,"state":183,"zip":202,"country":40,"countryCode":41,"cosmosGeoPoint":203,"geoPoint":205,"contacts":31},"Cleveland Clinic","ACTIVE_NOT_RECRUITING","44195",{"type":43,"coordinates":204},[196,197],{"lat":197,"lon":196},{"facility":207,"status":36,"city":208,"state":183,"zip":209,"country":40,"countryCode":41,"cosmosGeoPoint":210,"geoPoint":214,"contacts":31},"Zangmeister Cancer Center","Columbus","43219",{"type":43,"coordinates":211},[212,213],-82.99879,39.96118,{"lat":213,"lon":212},{"facility":216,"status":36,"city":217,"state":218,"zip":219,"country":40,"countryCode":41,"cosmosGeoPoint":220,"geoPoint":224,"contacts":31},"Oncology Associates of Oregon","Eugene","Oregon","97401",{"type":43,"coordinates":221},[222,223],-123.08675,44.05207,{"lat":223,"lon":222},{"facility":226,"status":227,"city":228,"state":229,"zip":230,"country":40,"countryCode":41,"cosmosGeoPoint":231,"geoPoint":235,"contacts":31},"UPMC Hillman Cancer Center","WITHDRAWN","Pittsburgh","Pennsylvania","15232",{"type":43,"coordinates":232},[233,234],-79.99589,40.44062,{"lat":234,"lon":233},{"facility":237,"status":36,"city":238,"state":239,"zip":240,"country":40,"countryCode":41,"cosmosGeoPoint":241,"geoPoint":245,"contacts":31},"Medical University of South Carolina Hollings Cancer Center","Charleston","South Carolina","29425",{"type":43,"coordinates":242},[243,244],-79.93275,32.77632,{"lat":244,"lon":243},{"facility":247,"status":36,"city":248,"state":249,"zip":250,"country":40,"countryCode":41,"cosmosGeoPoint":251,"geoPoint":255,"contacts":31},"SCRI Oncology Partners","Nashville","Tennessee","37203",{"type":43,"coordinates":252},[253,254],-86.78444,36.16589,{"lat":254,"lon":253},{"facility":257,"status":36,"city":258,"state":259,"zip":260,"country":40,"countryCode":41,"cosmosGeoPoint":261,"geoPoint":265,"contacts":31},"Texas Oncology-Baylor Charles A. Sammons Cancer Center","Dallas","Texas","75246",{"type":43,"coordinates":262},[263,264],-96.80667,32.78306,{"lat":264,"lon":263},{"facility":267,"status":36,"city":258,"state":259,"zip":268,"country":40,"countryCode":41,"cosmosGeoPoint":269,"geoPoint":271,"contacts":31},"University of Texas Southwestern Medical Center","75390",{"type":43,"coordinates":270},[263,264],{"lat":264,"lon":263},{"facility":273,"status":36,"city":274,"state":275,"zip":276,"country":40,"countryCode":41,"cosmosGeoPoint":277,"geoPoint":281,"contacts":31},"Oncology & Hematology Associates of Southwest Virginia","Blacksburg","Virginia","24073",{"type":43,"coordinates":278},[279,280],-80.41394,37.22957,{"lat":280,"lon":279},{"facility":283,"status":284,"city":285,"state":275,"zip":286,"country":40,"countryCode":41,"cosmosGeoPoint":287,"geoPoint":291,"contacts":31},"Universtity of Virginia Health System","COMPLETED","Charlottesville","22908",{"type":43,"coordinates":288},[289,290],-78.47668,38.02931,{"lat":290,"lon":289},{"facility":293,"status":36,"city":294,"state":275,"zip":295,"country":40,"countryCode":41,"cosmosGeoPoint":296,"geoPoint":300,"contacts":31},"Virginia Cancer Specialists Research Institute","Fairfax","22031",{"type":43,"coordinates":297},[298,299],-77.30637,38.84622,{"lat":299,"lon":298},{"facility":302,"status":36,"city":303,"state":304,"zip":305,"country":40,"countryCode":41,"cosmosGeoPoint":306,"geoPoint":310,"contacts":31},"Northwest Cancer Specialists","Vancouver","Washington","98686",{"type":43,"coordinates":307},[308,309],-122.66149,45.63873,{"lat":309,"lon":308},{"facility":312,"status":36,"city":313,"state":314,"zip":315,"country":40,"countryCode":41,"cosmosGeoPoint":316,"geoPoint":320,"contacts":31},"Marshfield Medical Center","Marshfield","Wisconsin","54449",{"type":43,"coordinates":317},[318,319],-90.1718,44.66885,{"lat":319,"lon":318},{"type":322,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100523424","phase-2-a-study-of-alisertib-in-patients-with-extensive-stage-small-cell-lung-cancer-100523424",false,"NCT06095505","A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer","A Phase 2 Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer","ALISCA-Lung1","Inclusion Criteria:\n\n* Aged ≥18 years at signing of informed consent\n* Pathologically confirmed SCLC\n* Prior treatment with one platinum-based chemotherapy and an anti-PD-L1\u002FPD-1 immunotherapy. Up to one additional systemic anti-cancer therapy for SCLC is allowed, for a total of up to two prior treatment regimens\n\nExclusion Criteria:\n\n* Prior treatment with an AURKA specific-targeted or pan-Aurora-targeted agent, including alisertib in any setting\n\nNote: There are additional inclusion and exclusion criteria. The study center will determine if you meet all of the criteria.","ALL","18 Years",{"count":334,"type":335},120,"ESTIMATED","INTERVENTIONAL",[338],"PHASE2","PUMA-ALI-4201 is a Phase 2 study evaluating alisertib monotherapy in patients with pathologically-confirmed small cell lung cancer (SCLC) following progression on or after treatment with one platinum-based chemotherapy and anti-PD-L1\u002FPD-1 immunotherapy agent. Up to one additional systemic anti-cancer therapy for SCLC is allowed, for a total of up to two prior treatment regimens. This study is intended to identify the biomarker-defined subgroup(s) that may benefit most from alisertib treatment and to evaluate the efficacy, safety, and pharmacokinetics of alisertib.",[341],"Small Cell Lung Cancer",[9,343],"SCLC","2026-06-03",{"date":346,"type":347},"2026-06-05","ACTUAL",{"date":349,"type":347},"2024-02-08",{"date":351,"type":335},"2028-04-30",{"name":5,"class":6},30]