[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621668":3},{"organization":4,"armGroups":7,"interventions":43,"overallOfficials":49,"centralContacts":75,"locations":81,"responsibleParty":95,"collaborators":49,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":49,"eligibilityCriteria":103,"healthyVolunteers":99,"sex":104,"minAge":105,"maxAge":49,"enrollmentInfo":106,"targetDuration":49,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":49,"overallStatus":115,"whyStopped":49,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Boryung Pharmaceutical Co., Ltd","INDUSTRY",[8,16,22,27,32,38],{"label":9,"type":10,"description":11,"interventionNames":12},"BR1400-1 + BR1400-B + BR1400-C","EXPERIMENTAL","Patients will receive tablet BR1400-1 + BR1400-B (Placebo of BR1400-2 \\& BR1400-4)+ BR1400-C (Placebo of BR1400-5)",[13,14,15],"Drug: BR1400-1","Drug: BR1400-B","Drug: BR1400-C",{"label":17,"type":10,"description":18,"interventionNames":19},"BR1400-A + BR1400-2 + BR1400-C","Patients will receive BR1400-A (Placebo of BR1400-1 \\& BR1400-3) + BR1400-2 + BR1400-C (Placebo of BR1400-5)",[20,21,15],"Drug: BR1400-2","Drug: BR1400-A",{"label":23,"type":10,"description":24,"interventionNames":25},"BR1400-3 + BR1400-B + BR1400-C","Patients will receive BR1400-3 + BR1400-B (Placebo of BR1400-2 \\& BR1400-4) + BR1400-C (Placebo of BR1400-5)",[26,14,15],"Drug: BR1400-3",{"label":28,"type":10,"description":29,"interventionNames":30},"BR1400-A + BR1400-4 + BR1400-C","Patients will receive BR1400-A (Placebo of BR1400-1 \\& BR1400-3) + BR1400-4 + BR1400-C (Placebo of BR1400-5)",[31,21,15],"Drug: BR1400-4",{"label":33,"type":34,"description":35,"interventionNames":36},"BR1400-A + BR1400-B + BR1400-5","OTHER","Patients will receive BR1400-A (Placebo of BR1400-1 \\& BR1400-3) + BR1400-B (Placebo of BR1400-2 \\& BR1400-4) + BR1400-5",[37,21,14],"Drug: BR1400-5",{"label":39,"type":40,"description":41,"interventionNames":42},"BR1400-A + BR1400-B + BR1400-C","PLACEBO_COMPARATOR","Patients will receive BR1400-A (Placebo of BR1400-1 \\& BR1400-3) + BR1400-B (Placebo of BR1400-2 \\& BR1400-4) + BR1400-C (Placebo of BR1400-5)",[21,14,15],[44,50,53,56,59,62,67,71],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"DRUG","BR1400-1","One tablet administered alone",[9],null,{"type":45,"name":51,"description":47,"armGroupLabels":52,"otherNames":49},"BR1400-2",[17],{"type":45,"name":54,"description":47,"armGroupLabels":55,"otherNames":49},"BR1400-3",[23],{"type":45,"name":57,"description":47,"armGroupLabels":58,"otherNames":49},"BR1400-4",[28],{"type":45,"name":60,"description":47,"armGroupLabels":61,"otherNames":49},"BR1400-5",[33],{"type":45,"name":63,"description":47,"armGroupLabels":64,"otherNames":65},"BR1400-A",[17,28,33,39],[66],"Placebo",{"type":45,"name":68,"description":47,"armGroupLabels":69,"otherNames":70},"BR1400-B",[9,23,33,39],[66],{"type":45,"name":72,"description":47,"armGroupLabels":73,"otherNames":74},"BR1400-C",[9,23,17,28,39],[66],[76],{"name":77,"role":78,"phone":79,"phoneExt":49,"email":80},"Soo Hee Kim","CONTACT","+82-2-708-8000","shkim0127@boryung.co.kr",[82],{"facility":83,"status":49,"city":84,"state":49,"zip":49,"country":85,"countryCode":49,"cosmosGeoPoint":86,"geoPoint":91,"contacts":92},"Hanyang University Hospital","Soeul","South Korea",{"type":87,"coordinates":88},"Point",[89,90],126.7319,36.9168,{"lat":90,"lon":89},[93],{"name":94,"role":78,"phone":49,"phoneExt":49,"email":49},"Jinho Shin, MD.,PhD",{"type":96,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR","100621668","phase-2-a-study-of-br1400-1-br1400-2-br1400-3-br1400-4-and-br1400-5-in-patients-with-essential-hypertension-100621668",false,"NCT07373613","A Study of BR1400-1, BR1400-2, BR1400-3, BR1400-4, and BR1400-5 in Patients With Essential Hypertension","A Randomized, Multi-center, Double-Blind, Controlled, Parallel Design, Phase II Study to Evaluate the Efficacy and Safety Administration by Doses of BR1400-1, BR1400-2, BR1400-3, BR1400-4, and BR1400-5 in Patients With Essential Hypertension","Inclusion Criteria:\n\n\\\u003CScreening Visit (V1)\\>\n\nPatients with essential hypertension whose mean sitting systolic blood pressure (MSSBP) measured in the reference arm at the screening (Visit 1) meets the following criteria:\n\n* For patients not currently receiving antihypertensive therapy: 140 mmHg ≤ MSSBP \\\u003C 180 mmHg\n* For patients receiving antihypertensive therapy : 130 mmHg ≤ MSSBP \\\u003C 180 mmHg\n\nFor patients receiving antihypertensive therapy at the screening (Visit 1), those for whom the investigator determines that it is medically appropriate to temporarily discontinue their current antihypertensive treatment during the study.\n\n\\\u003CBaseline Visit (V2)\\>\n\nPatients with essential hypertension whose mean sitting systolic blood pressure (MSSBP) measured in the reference arm at the baseline (Visit 2) prior to randomization meets the following criteria:\n\n* For patients without cardiovascular disease: 140 mmHg ≤ MSSBP \\\u003C 180 mmHg\n* For patients with cardiovascular disease, diabetes with cardiovascular disease, albuminuria, or diabetes with chronic kidney disease (CKD): 130 mmHg ≤ MSSBP \\\u003C 180 mmHg\n\nExclusion Criteria:\n\n* Patients with blood pressure results showing MSSBP ≥ 180 mmHg or MSDBP ≥ 110 mmHg at screening(V1) and baseline(V2)\n* Patients with a history of secondary hypertension or suspected secondary hypertension; (e.g., coarctation of the aorta, hyperaldosteronism, renal artery stenosis, renal hypertension, pheochromocytoma, Cushing's syndrome and polycystic kidney disease, etc.)\n* Patients with shock\n* Patients with orthostatic hypotension accompanied by symptoms","ALL","19 Years",{"count":107,"type":108},330,"ESTIMATED","INTERVENTIONAL",[111],"PHASE2","The objective of this clinical trial is to evaluate the antihypertensive efficacy and safety of BR1400-1, BR1400-2, BR1400-3, BR1400-4, and BR1400-5 with essential hypertension.",[114],"Essential Hypertension","NOT_YET_RECRUITING","2026-01-20",{"date":118,"type":119},"2026-01-28","ACTUAL",{"date":121,"type":108},"2026-03-01",{"date":123,"type":108},"2027-02-01",{"name":5,"class":6},1]