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self-inject study intervention Note: Participants who are not able to perform the injections must have the assistance of a support person trained to administer the study intervention\n  * store and use the provided study intervention as directed\n  * maintain electronic or paper study diaries, as applicable, and\n  * complete the required questionnaires\n* Are intermittently using non-legal, non-prescribed opioids\n* Are taking buprenorphine for treatment on OUD\n\nExclusion Criteria:\n\n* Evidence of other substance use disorder(s) within 180 days of screening, except the following are permitted: any level tobacco use disorder, mild-to-moderate alcohol or mild-to-moderate cannabis use disorder\n\nNote: any level of caffeine use is allowed\n\n* Are actively suicidal or deemed a significant risk for suicide\n* Have a history of advanced liver disease (including advanced liver fibrosis or cirrhosis or alcohol-associated hepatitis based on either prior liver histology or imaging studies, such as transient elastography, ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI), or Enhanced Liver Fibrosis score\n* Have participated in a clinical study and received active treatment, or unknown if they received active treatment, within 90 days or 5 half-lives (whichever is longer) before screening\n* Had opioid overdose in past 6 months prior to screening\n* Have a lifetime history or current diagnosis of the following:\n\n  * schizophrenia or other psychotic disorder\n  * bipolar disorder\n  * borderline personality disorder\n  * any eating disorder\n* Have type 1 diabetes mellitus, or a history of ketoacidosis, or hyperosmolar state, or coma","ALL","18 Years","75 Years",{"count":808,"type":809},465,"ESTIMATED","INTERVENTIONAL",[812],"PHASE2","The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone.\n\nThe maximum 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The actual duration will vary for each participant depending on the time of enrollment and the overall rate of study enrollment.",[815],"Opioid Use Disorder","2026-06-19",{"date":818,"type":819},"2026-06-23","ACTUAL",{"date":821,"type":819},"2026-02-13",{"date":823,"type":809},"2028-03",{"name":5,"class":6},57]