[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100352269":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":53,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":29,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":29,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":36,"whyStopped":29,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Stanford University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Esomeprazole","EXPERIMENTAL","Esomeprazole Dosage (Weight Less Than 20 kg) -- 10 mg QD for 8 weeks Esomeprazole Dosage (Weight 20 kg or Greater) -- 10 mg QD for 4 weeks followed by 20 mg QD for 4 weeks",[13],"Drug: Esomeprazole",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"DRUG",[9],[19],"Nexium",[21],{"name":22,"affiliation":5,"role":23},"Antonio Hardan, MD","PRINCIPAL_INVESTIGATOR",[25,31],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Nina Raman","CONTACT","(650)736-1235",null,"autismdd@stanford.edu",{"name":32,"role":27,"phone":28,"phoneExt":29,"email":30},"Briana Hernandez",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Stanford University School of Medicine","RECRUITING","Stanford","California","94305","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-122.16608,37.42411,{"lat":46,"lon":45},[49,50],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},{"name":51,"role":27,"phone":28,"phoneExt":29,"email":52},"Robin Libove","rlibove@stanford.edu",{"type":23,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Antonio Hardan","Principal Investigator",[57],{"name":58,"class":59},"SPARK (Stanford University)","UNKNOWN","100352269","phase-2-a-study-of-esomeprazole-in-children-with-autism-100352269",false,"NCT03866668","A Study of Esomeprazole in Children With Autism","An Open-Label Pilot Study of Esomeprazole in Children With Autism","Inclusion Criteria:\n\n* outpatients 2 to 6 years of age;\n* males and females who are physically healthy;\n* diagnosis of autism spectrum disorder based on clinical evaluation and DSM-5 criteria, and confirmed using the Autism Diagnostic Interview-Revised, and the Autism Diagnostic Observation Schedule or Childhood Autism Rating Scale second edition (CARS-2)\n* care provider who could reliably bring subject to clinic visits, could provide trustworthy ratings, and interacted with subject on a regular basis;\n* ability of subject to swallow the compound;\n* stable concomitant medications for at least 2 weeks (4 weeks if patient took fluoxetine);\n* no planned changes in psychosocial interventions during the open-label trial.\n\nExclusion Criteria:\n\n* DSM-5 diagnosis of schizophrenia, schizoaffective disorder, or psychotic disorder not otherwise specified;\n* prior adequate trial of Esomeprazole;\n* active medical problems such as unstable seizures, or significant physical illness (e.g., serious liver or renal pathology).","ALL","2 Years","6 Years",{"count":71,"type":72},25,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","Autism is a pervasive developmental disorder characterized by core deficits in social behavior and communication and the presence of repetitive\u002Fstereotyped behaviors. The objective of the study is to evaluate the efficacy of Esomeprazole as a treatment for social communication deficits in children with Autism Spectrum Disorder (ASD). This prospective 12 week open-label study will invite 25 children with ASD between the ages of 2 and 6 years of age to participate.",[78,79],"Autism","Autism Spectrum Disorder",[9],"2026-06-22",{"date":83,"type":84},"2026-06-25","ACTUAL",{"date":86,"type":84},"2019-05-29",{"date":88,"type":72},"2028-12",{"name":5,"class":6},1]