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with isolated ileal disease, based on the presence of ulceration in any 1 of the 5 ileocolonic segments\n* A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (beta-hCG) at screening and a negative urine pregnancy test at Week I-0 prior to administration of study intervention and agree to further pregnancy tests\n* Demonstrated an inadequate response to, or failure to tolerate conventional therapy but naïve to advanced therapies (advanced drug therapy \\[ADT\\]-naïve) or inadequate response to (that is, primary or secondary nonresponse) or failure to tolerate advanced therapy defined as biologics and\u002For advanced oral agents for the treatment of CD- (ADT-inadequate responder \\[IR\\]) as defined in the protocol\n\nExclusion criteria:\n\n* Has complications of CD, such as symptomatic strictures or stenoses, short gut syndrome, or any other manifestation, that may require surgery while enrolled in the study and\u002For could 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