[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594759":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":750,"collaborators":752,"id":759,"slug":760,"hasResults":761,"nctId":762,"briefTitle":763,"officialTitle":764,"acronym":765,"eligibilityCriteria":766,"healthyVolunteers":761,"sex":767,"minAge":768,"maxAge":769,"enrollmentInfo":770,"targetDuration":26,"studyType":773,"phases":774,"briefSummary":776,"conditions":777,"keywords":779,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":780,"lastUpdatePostDateStruct":781,"startDateStruct":784,"completionDateStruct":786,"leadSponsor":788,"locationsCount":789},{"fullName":5,"class":6},"Incyte Corporation","INDUSTRY",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1","EXPERIMENTAL","INCB123667 will be administered at the protocol defined dose based on their tumor cyclin E1 expression levels as defined in the protocol.",[13],"Drug: INCB123667",{"label":15,"type":10,"description":11,"interventionNames":16},"Cohort 2",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Cohort 3",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","INCB123667","Administered orally twice daily (BID).",[9,15,18],null,[28],{"name":29,"affiliation":5,"role":30},"Incyte Medical Monitor","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Incyte Corporation Call Center (US)","CONTACT","1.855.463.3463","medinfo@incyte.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Incyte Corporation Call Center (ex-US)","+800 00027423","eumedinfo@incyte.com",[42,56,66,75,85,95,104,113,121,131,141,151,161,171,181,191,201,211,221,231,241,251,261,271,281,290,299,308,318,327,336,346,355,365,375,384,393,402,412,422,431,441,451,463,472,482,492,498,501,512,518,527,536,545,551,555,564,573,582,591,595,606,617,623,629,638,647,656,662,671,680,686,697,705,714,723,734,740,746],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":26},"Usa Health Mitchell Cancer Institute","RECRUITING","Mobile","Alabama","36604","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-88.04305,30.69436,{"lat":54,"lon":53},{"facility":57,"status":44,"city":58,"state":59,"zip":60,"country":48,"countryCode":49,"cosmosGeoPoint":61,"geoPoint":65,"contacts":26},"University of California, Los Angeles Medical Center","Los Angeles","California","90024-6995",{"type":51,"coordinates":62},[63,64],-118.24368,34.05223,{"lat":64,"lon":63},{"facility":67,"status":44,"city":68,"state":59,"zip":69,"country":48,"countryCode":49,"cosmosGeoPoint":70,"geoPoint":74,"contacts":26},"Scripps Healthscripps Mercy Hospital Prebys Cancer Center","San Diego","92103",{"type":51,"coordinates":71},[72,73],-117.16472,32.71571,{"lat":73,"lon":72},{"facility":76,"status":44,"city":77,"state":78,"zip":79,"country":48,"countryCode":49,"cosmosGeoPoint":80,"geoPoint":84,"contacts":26},"Medstar Georgetown University Hospital","Washington D.C.","District of Columbia","20010",{"type":51,"coordinates":81},[82,83],-77.03637,38.89511,{"lat":83,"lon":82},{"facility":86,"status":44,"city":87,"state":88,"zip":89,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":94,"contacts":26},"Florida Cancer Specialists & Research Institute","Fort Myers","Florida","33901",{"type":51,"coordinates":91},[92,93],-81.84059,26.62168,{"lat":93,"lon":92},{"facility":96,"status":44,"city":97,"state":88,"zip":98,"country":48,"countryCode":49,"cosmosGeoPoint":99,"geoPoint":103,"contacts":26},"Sylvester Comprehensive Cancer Center","Miami","33136",{"type":51,"coordinates":100},[101,102],-80.19366,25.77427,{"lat":102,"lon":101},{"facility":105,"status":44,"city":106,"state":88,"zip":107,"country":48,"countryCode":49,"cosmosGeoPoint":108,"geoPoint":112,"contacts":26},"Mount Sinai Comprehensive Cancer Center","Miami Beach","33140",{"type":51,"coordinates":109},[110,111],-80.13005,25.79065,{"lat":111,"lon":110},{"facility":86,"status":44,"city":114,"state":88,"zip":115,"country":48,"countryCode":49,"cosmosGeoPoint":116,"geoPoint":120,"contacts":26},"West Palm Beach","33401",{"type":51,"coordinates":117},[118,119],-80.05337,26.71534,{"lat":119,"lon":118},{"facility":122,"status":44,"city":123,"state":124,"zip":125,"country":48,"countryCode":49,"cosmosGeoPoint":126,"geoPoint":130,"contacts":26},"Northeast Georgia Medical Center Gainesville","Gainesville","Georgia","30501",{"type":51,"coordinates":127},[128,129],-83.82407,34.29788,{"lat":129,"lon":128},{"facility":132,"status":44,"city":133,"state":134,"zip":135,"country":48,"countryCode":49,"cosmosGeoPoint":136,"geoPoint":140,"contacts":26},"Parkview Research Center","Fort Wayne","Indiana","46845",{"type":51,"coordinates":137},[138,139],-85.12886,41.1306,{"lat":139,"lon":138},{"facility":142,"status":143,"city":144,"state":134,"zip":145,"country":48,"countryCode":49,"cosmosGeoPoint":146,"geoPoint":150,"contacts":26},"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","WITHDRAWN","Indianapolis","46202",{"type":51,"coordinates":147},[148,149],-86.15804,39.76838,{"lat":149,"lon":148},{"facility":152,"status":44,"city":153,"state":154,"zip":155,"country":48,"countryCode":49,"cosmosGeoPoint":156,"geoPoint":160,"contacts":26},"University of Iowa Hospital and Clinics","Iowa City","Iowa","52242-1009",{"type":51,"coordinates":157},[158,159],-91.53017,41.66113,{"lat":159,"lon":158},{"facility":162,"status":44,"city":163,"state":164,"zip":165,"country":48,"countryCode":49,"cosmosGeoPoint":166,"geoPoint":170,"contacts":26},"Norton Cancer Institute","Louisville","Kentucky","40207",{"type":51,"coordinates":167},[168,169],-85.75941,38.25424,{"lat":169,"lon":168},{"facility":172,"status":44,"city":173,"state":174,"zip":175,"country":48,"countryCode":49,"cosmosGeoPoint":176,"geoPoint":180,"contacts":26},"Trials365, Llc","Shreveport","Louisiana","71103",{"type":51,"coordinates":177},[178,179],-93.75018,32.52515,{"lat":179,"lon":178},{"facility":182,"status":44,"city":183,"state":184,"zip":185,"country":48,"countryCode":49,"cosmosGeoPoint":186,"geoPoint":190,"contacts":26},"Greater Baltimore Medical Center","Baltimore","Maryland","21204",{"type":51,"coordinates":187},[188,189],-76.61219,39.29038,{"lat":189,"lon":188},{"facility":192,"status":44,"city":193,"state":194,"zip":195,"country":48,"countryCode":49,"cosmosGeoPoint":196,"geoPoint":200,"contacts":26},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":51,"coordinates":197},[198,199],-71.05977,42.35843,{"lat":199,"lon":198},{"facility":202,"status":203,"city":204,"state":194,"zip":205,"country":48,"countryCode":49,"cosmosGeoPoint":206,"geoPoint":210,"contacts":26},"Umass Memorial Medical Center, Inc.","NOT_YET_RECRUITING","Worcester","01605",{"type":51,"coordinates":207},[208,209],-71.80229,42.26259,{"lat":209,"lon":208},{"facility":212,"status":203,"city":213,"state":214,"zip":215,"country":48,"countryCode":49,"cosmosGeoPoint":216,"geoPoint":220,"contacts":26},"University of Michigan Health System","Ann Arbor","Michigan","48109",{"type":51,"coordinates":217},[218,219],-83.74088,42.27756,{"lat":219,"lon":218},{"facility":222,"status":44,"city":223,"state":224,"zip":225,"country":48,"countryCode":49,"cosmosGeoPoint":226,"geoPoint":230,"contacts":26},"Minnesota Oncology-Minneapolis","Minneapolis","Minnesota","55404",{"type":51,"coordinates":227},[228,229],-93.26384,44.97997,{"lat":229,"lon":228},{"facility":232,"status":203,"city":233,"state":234,"zip":235,"country":48,"countryCode":49,"cosmosGeoPoint":236,"geoPoint":240,"contacts":26},"University of Mississippi Medical Center","Jackson","Mississippi","39216",{"type":51,"coordinates":237},[238,239],-90.18481,32.29876,{"lat":239,"lon":238},{"facility":242,"status":44,"city":243,"state":244,"zip":245,"country":48,"countryCode":49,"cosmosGeoPoint":246,"geoPoint":250,"contacts":26},"Washington University","St Louis","Missouri","63110",{"type":51,"coordinates":247},[248,249],-90.19789,38.62727,{"lat":249,"lon":248},{"facility":252,"status":44,"city":253,"state":254,"zip":255,"country":48,"countryCode":49,"cosmosGeoPoint":256,"geoPoint":260,"contacts":26},"St. Vincent Regional Hospital - West End Clinic","Billings","Montana","59106",{"type":51,"coordinates":257},[258,259],-108.50069,45.78329,{"lat":259,"lon":258},{"facility":262,"status":44,"city":263,"state":264,"zip":265,"country":48,"countryCode":49,"cosmosGeoPoint":266,"geoPoint":270,"contacts":26},"Nebraska Methodist Hospital","Omaha","Nebraska","68114",{"type":51,"coordinates":267},[268,269],-95.94043,41.25626,{"lat":269,"lon":268},{"facility":272,"status":44,"city":273,"state":274,"zip":275,"country":48,"countryCode":49,"cosmosGeoPoint":276,"geoPoint":280,"contacts":26},"John Theurer Cancer Center, Hackensack University Medical Center","Hackensack","New Jersey","07601",{"type":51,"coordinates":277},[278,279],-74.04347,40.88593,{"lat":279,"lon":278},{"facility":282,"status":44,"city":283,"state":283,"zip":284,"country":48,"countryCode":49,"cosmosGeoPoint":285,"geoPoint":289,"contacts":26},"Laura and Isaac Perlmutter Cancer Center","New York","10016",{"type":51,"coordinates":286},[287,288],-74.00597,40.71427,{"lat":288,"lon":287},{"facility":291,"status":143,"city":292,"state":283,"zip":293,"country":48,"countryCode":49,"cosmosGeoPoint":294,"geoPoint":298,"contacts":26},"University of Rochester, James P. Wilmot Cancer Center","Rochester","14642",{"type":51,"coordinates":295},[296,297],-77.61556,43.15478,{"lat":297,"lon":296},{"facility":300,"status":203,"city":301,"state":283,"zip":302,"country":48,"countryCode":49,"cosmosGeoPoint":303,"geoPoint":307,"contacts":26},"State University of New York Upstate Medical Unive","Syracuse","13210",{"type":51,"coordinates":304},[305,306],-76.14742,43.04812,{"lat":306,"lon":305},{"facility":309,"status":44,"city":310,"state":311,"zip":312,"country":48,"countryCode":49,"cosmosGeoPoint":313,"geoPoint":317,"contacts":26},"Oncology Hematology Care, Inc","Cincinnati","Ohio","45242",{"type":51,"coordinates":314},[315,316],-84.51439,39.12711,{"lat":316,"lon":315},{"facility":319,"status":44,"city":320,"state":311,"zip":321,"country":48,"countryCode":49,"cosmosGeoPoint":322,"geoPoint":326,"contacts":26},"The Mark H Zangmeister Cancer Center Ohio","Columbus","43219",{"type":51,"coordinates":323},[324,325],-82.99879,39.96118,{"lat":325,"lon":324},{"facility":328,"status":44,"city":329,"state":311,"zip":330,"country":48,"countryCode":49,"cosmosGeoPoint":331,"geoPoint":335,"contacts":26},"The Ohio State University Wexner Medical Center Division of Gynecologic Oncology","Hilliard","43026",{"type":51,"coordinates":332},[333,334],-83.15825,40.0334,{"lat":334,"lon":333},{"facility":337,"status":203,"city":338,"state":339,"zip":340,"country":48,"countryCode":49,"cosmosGeoPoint":341,"geoPoint":345,"contacts":26},"Penn State College of Medicine","Hershey","Pennsylvania","17033",{"type":51,"coordinates":342},[343,344],-76.65025,40.28592,{"lat":344,"lon":343},{"facility":347,"status":143,"city":348,"state":339,"zip":349,"country":48,"countryCode":49,"cosmosGeoPoint":350,"geoPoint":354,"contacts":26},"Asplundh Cancer Pavilion - Thomas Jefferson","Willow Grove","19090",{"type":51,"coordinates":351},[352,353],-75.11573,40.144,{"lat":353,"lon":352},{"facility":356,"status":203,"city":357,"state":358,"zip":359,"country":48,"countryCode":49,"cosmosGeoPoint":360,"geoPoint":364,"contacts":26},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":51,"coordinates":361},[362,363],-79.93275,32.77632,{"lat":363,"lon":362},{"facility":366,"status":44,"city":367,"state":368,"zip":369,"country":48,"countryCode":49,"cosmosGeoPoint":370,"geoPoint":374,"contacts":26},"Texas Oncology-Austin Center","Austin","Texas","78731",{"type":51,"coordinates":371},[372,373],-97.74306,30.26715,{"lat":373,"lon":372},{"facility":376,"status":143,"city":377,"state":368,"zip":378,"country":48,"countryCode":49,"cosmosGeoPoint":379,"geoPoint":383,"contacts":26},"Houston Methodist Cancer Center","Houston","77030",{"type":51,"coordinates":380},[381,382],-95.36327,29.76328,{"lat":382,"lon":381},{"facility":385,"status":44,"city":386,"state":368,"zip":387,"country":48,"countryCode":49,"cosmosGeoPoint":388,"geoPoint":392,"contacts":26},"Texas Oncology-San Antonio Medical Center Pharmacy","San Antonio","78229",{"type":51,"coordinates":389},[390,391],-98.49363,29.42412,{"lat":391,"lon":390},{"facility":394,"status":44,"city":395,"state":368,"zip":396,"country":48,"countryCode":49,"cosmosGeoPoint":397,"geoPoint":401,"contacts":26},"Texas Oncology-Tyler","Tyler","75702",{"type":51,"coordinates":398},[399,400],-95.30106,32.35126,{"lat":400,"lon":399},{"facility":403,"status":44,"city":404,"state":405,"zip":406,"country":48,"countryCode":49,"cosmosGeoPoint":407,"geoPoint":411,"contacts":26},"Utah Cancer Specialists","Salt Lake City","Utah","84106",{"type":51,"coordinates":408},[409,410],-111.89105,40.76078,{"lat":410,"lon":409},{"facility":413,"status":44,"city":414,"state":415,"zip":416,"country":48,"countryCode":49,"cosmosGeoPoint":417,"geoPoint":421,"contacts":26},"Virginia Cancer Specialists","Fairfax","Virginia","22031",{"type":51,"coordinates":418},[419,420],-77.30637,38.84622,{"lat":420,"lon":419},{"facility":423,"status":44,"city":424,"state":415,"zip":425,"country":48,"countryCode":49,"cosmosGeoPoint":426,"geoPoint":430,"contacts":26},"Carilion Clinic","Roanoke","24016-4962",{"type":51,"coordinates":427},[428,429],-79.94143,37.27097,{"lat":429,"lon":428},{"facility":432,"status":44,"city":433,"state":434,"zip":435,"country":48,"countryCode":49,"cosmosGeoPoint":436,"geoPoint":440,"contacts":26},"West Virginia University","Morgantown","West Virginia","26506",{"type":51,"coordinates":437},[438,439],-79.9559,39.62953,{"lat":439,"lon":438},{"facility":442,"status":203,"city":443,"state":444,"zip":445,"country":48,"countryCode":49,"cosmosGeoPoint":446,"geoPoint":450,"contacts":26},"Froedtert & the Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":51,"coordinates":447},[448,449],-87.90647,43.0389,{"lat":449,"lon":448},{"facility":452,"status":203,"city":453,"state":454,"zip":455,"country":456,"countryCode":457,"cosmosGeoPoint":458,"geoPoint":462,"contacts":26},"Blacktown Cancer & Haematology Centre-Blacktown Hospital","Blacktown","New South Wales","02148","Australia","AU",{"type":51,"coordinates":459},[460,461],150.91667,-33.76667,{"lat":461,"lon":460},{"facility":464,"status":203,"city":465,"state":454,"zip":466,"country":456,"countryCode":457,"cosmosGeoPoint":467,"geoPoint":471,"contacts":26},"Concord General Repatriation Hospital","Concord","02139",{"type":51,"coordinates":468},[469,470],151.10381,-33.84722,{"lat":470,"lon":469},{"facility":473,"status":44,"city":474,"state":475,"zip":476,"country":456,"countryCode":457,"cosmosGeoPoint":477,"geoPoint":481,"contacts":26},"Burnside War Memorial Hospital - the Brian Fricker Oncology Centre","Adelaide","South Australia","05065",{"type":51,"coordinates":478},[479,480],138.59863,-34.92866,{"lat":480,"lon":479},{"facility":483,"status":44,"city":484,"state":485,"zip":486,"country":456,"countryCode":457,"cosmosGeoPoint":487,"geoPoint":491,"contacts":26},"Hobart Hospital-Royal Hobart Hospital","Hobart","Tasmania","07000",{"type":51,"coordinates":488},[489,490],147.32941,-42.87936,{"lat":490,"lon":489},{"facility":493,"status":44,"city":474,"state":26,"zip":494,"country":456,"countryCode":457,"cosmosGeoPoint":495,"geoPoint":497,"contacts":26},"Cancer Research Sa (Crsa)","05000",{"type":51,"coordinates":496},[479,480],{"lat":480,"lon":479},{"facility":499,"status":143,"city":475,"state":26,"zip":500,"country":456,"countryCode":457,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Southern Oncology Clinical Research Unit","05042",{"facility":502,"status":44,"city":503,"state":26,"zip":504,"country":505,"countryCode":506,"cosmosGeoPoint":507,"geoPoint":511,"contacts":26},"Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet","Brussels","01070","Belgium","BE",{"type":51,"coordinates":508},[509,510],4.34878,50.85045,{"lat":510,"lon":509},{"facility":513,"status":44,"city":503,"state":26,"zip":514,"country":505,"countryCode":506,"cosmosGeoPoint":515,"geoPoint":517,"contacts":26},"Cliniques Universitaires St Luc Ucl","B-1200",{"type":51,"coordinates":516},[509,510],{"lat":510,"lon":509},{"facility":519,"status":44,"city":520,"state":26,"zip":521,"country":505,"countryCode":506,"cosmosGeoPoint":522,"geoPoint":526,"contacts":26},"Az Groeninge","Kortrijk","08500",{"type":51,"coordinates":523},[524,525],3.26487,50.82803,{"lat":525,"lon":524},{"facility":528,"status":44,"city":529,"state":26,"zip":530,"country":505,"countryCode":506,"cosmosGeoPoint":531,"geoPoint":535,"contacts":26},"Universitair Ziekenhuis Leuven","Leuven","03000",{"type":51,"coordinates":532},[533,534],4.70093,50.87959,{"lat":534,"lon":533},{"facility":537,"status":203,"city":538,"state":26,"zip":539,"country":505,"countryCode":506,"cosmosGeoPoint":540,"geoPoint":544,"contacts":26},"Chu Liege","Liège","04000",{"type":51,"coordinates":541},[542,543],5.56749,50.63373,{"lat":543,"lon":542},{"facility":546,"status":44,"city":547,"state":26,"zip":548,"country":549,"countryCode":550,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Hyogo Cancer Center","Akashi-shi","673-8558","Japan","JP",{"facility":552,"status":44,"city":553,"state":26,"zip":554,"country":549,"countryCode":550,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Saitama Medical University International Medical Center","Hidaka-shi","350-1298",{"facility":556,"status":44,"city":557,"state":26,"zip":558,"country":549,"countryCode":550,"cosmosGeoPoint":559,"geoPoint":563,"contacts":26},"The Cancer Institute Hospital of Jfcr","Kōtoku","135-8550",{"type":51,"coordinates":560},[561,562],143.14297,42.50417,{"lat":562,"lon":561},{"facility":565,"status":44,"city":566,"state":26,"zip":567,"country":549,"countryCode":550,"cosmosGeoPoint":568,"geoPoint":572,"contacts":26},"Kurume University Hospital","Kurume","830-0011",{"type":51,"coordinates":569},[570,571],130.51667,33.31667,{"lat":571,"lon":570},{"facility":574,"status":44,"city":575,"state":26,"zip":576,"country":549,"countryCode":550,"cosmosGeoPoint":577,"geoPoint":581,"contacts":26},"Shikoku Cancer Center","Matsuyama","791-0280",{"type":51,"coordinates":578},[579,580],132.76574,33.83916,{"lat":580,"lon":579},{"facility":583,"status":44,"city":584,"state":26,"zip":585,"country":549,"countryCode":550,"cosmosGeoPoint":586,"geoPoint":590,"contacts":26},"Hokkaido University Hospital","Sapporo","060-8648",{"type":51,"coordinates":587},[588,589],141.35,43.06667,{"lat":589,"lon":588},{"facility":592,"status":44,"city":593,"state":26,"zip":594,"country":549,"countryCode":550,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Shizuoka Cancer Center","Sunto-gun","411-8777",{"facility":596,"status":44,"city":597,"state":598,"zip":599,"country":600,"countryCode":598,"cosmosGeoPoint":601,"geoPoint":605,"contacts":26},"Panoncology Trials","San Juan","PR","00935","Puerto Rico",{"type":51,"coordinates":602},[603,604],-66.10572,18.46633,{"lat":604,"lon":603},{"facility":607,"status":44,"city":608,"state":26,"zip":609,"country":610,"countryCode":611,"cosmosGeoPoint":612,"geoPoint":616,"contacts":26},"Hospital Universitario Vall D'Hebron","Barcelona","08035","Spain","ES",{"type":51,"coordinates":613},[614,615],2.15899,41.38879,{"lat":615,"lon":614},{"facility":618,"status":44,"city":608,"state":26,"zip":619,"country":610,"countryCode":611,"cosmosGeoPoint":620,"geoPoint":622,"contacts":26},"Hospital Clinic de Barcelona","08036",{"type":51,"coordinates":621},[614,615],{"lat":615,"lon":614},{"facility":624,"status":203,"city":608,"state":26,"zip":625,"country":610,"countryCode":611,"cosmosGeoPoint":626,"geoPoint":628,"contacts":26},"Instituto Catalan de Oncologia - Hospital Duran I Reynals","08908",{"type":51,"coordinates":627},[614,615],{"lat":615,"lon":614},{"facility":630,"status":203,"city":631,"state":26,"zip":632,"country":610,"countryCode":611,"cosmosGeoPoint":633,"geoPoint":637,"contacts":26},"Hospital Universitario Reina Sofia","Córdoba","14004",{"type":51,"coordinates":634},[635,636],-4.77275,37.89155,{"lat":636,"lon":635},{"facility":639,"status":44,"city":640,"state":26,"zip":641,"country":610,"countryCode":611,"cosmosGeoPoint":642,"geoPoint":646,"contacts":26},"Institut Catala D'Oncologia Girona","Girona","17007",{"type":51,"coordinates":643},[644,645],2.82493,41.98311,{"lat":645,"lon":644},{"facility":648,"status":44,"city":649,"state":26,"zip":650,"country":610,"countryCode":611,"cosmosGeoPoint":651,"geoPoint":655,"contacts":26},"Clinica Universidad de Navarra - Sede Madrid","Madrid","28027",{"type":51,"coordinates":652},[653,654],-3.70256,40.4165,{"lat":654,"lon":653},{"facility":657,"status":44,"city":649,"state":26,"zip":658,"country":610,"countryCode":611,"cosmosGeoPoint":659,"geoPoint":661,"contacts":26},"Hospital Universitario La Paz","28046",{"type":51,"coordinates":660},[653,654],{"lat":654,"lon":653},{"facility":663,"status":44,"city":664,"state":26,"zip":665,"country":610,"countryCode":611,"cosmosGeoPoint":666,"geoPoint":670,"contacts":26},"Hospital Universitario Virgen de La Arrixaca","Murcia","30120",{"type":51,"coordinates":667},[668,669],-1.13004,37.98704,{"lat":669,"lon":668},{"facility":672,"status":44,"city":673,"state":26,"zip":674,"country":610,"countryCode":611,"cosmosGeoPoint":675,"geoPoint":679,"contacts":26},"Fundacion Instituto Valenciano de Oncologia","Valencia","46009",{"type":51,"coordinates":676},[677,678],-0.37966,39.47391,{"lat":678,"lon":677},{"facility":681,"status":44,"city":673,"state":26,"zip":682,"country":610,"countryCode":611,"cosmosGeoPoint":683,"geoPoint":685,"contacts":26},"Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva)","46010",{"type":51,"coordinates":684},[677,678],{"lat":678,"lon":677},{"facility":687,"status":44,"city":688,"state":26,"zip":689,"country":690,"countryCode":691,"cosmosGeoPoint":692,"geoPoint":696,"contacts":26},"Istituto Oncologico Della Svizzera Italiana (Iosi) Di Bellinzona","Bellinzona","06500","Switzerland","CH",{"type":51,"coordinates":693},[694,695],9.01703,46.19278,{"lat":695,"lon":694},{"facility":698,"status":203,"city":699,"state":26,"zip":486,"country":690,"countryCode":691,"cosmosGeoPoint":700,"geoPoint":704,"contacts":26},"Kantonsspital Graubunden","Chur",{"type":51,"coordinates":701},[702,703],9.53287,46.84986,{"lat":703,"lon":702},{"facility":706,"status":44,"city":707,"state":26,"zip":708,"country":690,"countryCode":691,"cosmosGeoPoint":709,"geoPoint":713,"contacts":26},"Geneva University Hospitals-Hug","Geneva","01211",{"type":51,"coordinates":710},[711,712],6.14569,46.20222,{"lat":712,"lon":711},{"facility":715,"status":44,"city":716,"state":26,"zip":717,"country":690,"countryCode":691,"cosmosGeoPoint":718,"geoPoint":722,"contacts":26},"Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit","Lausanne","01011",{"type":51,"coordinates":719},[720,721],6.63282,46.516,{"lat":721,"lon":720},{"facility":724,"status":44,"city":725,"state":26,"zip":726,"country":727,"countryCode":728,"cosmosGeoPoint":729,"geoPoint":733,"contacts":26},"Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust","London","SE1 9RT","United Kingdom","UK",{"type":51,"coordinates":730},[731,732],-0.12574,51.50853,{"lat":732,"lon":731},{"facility":735,"status":44,"city":725,"state":26,"zip":736,"country":727,"countryCode":728,"cosmosGeoPoint":737,"geoPoint":739,"contacts":26},"Royal Marsden Hospital (Sutton) - Royal Marsden Nhs Foundation Trust","SM2 5PT",{"type":51,"coordinates":738},[731,732],{"lat":732,"lon":731},{"facility":741,"status":44,"city":725,"state":26,"zip":742,"country":727,"countryCode":728,"cosmosGeoPoint":743,"geoPoint":745,"contacts":26},"Hammersmith Hospital - Imperial College Healthcare Nhs Trust","W12 0HS",{"type":51,"coordinates":744},[731,732],{"lat":732,"lon":731},{"facility":747,"status":44,"city":748,"state":26,"zip":749,"country":727,"countryCode":728,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"The Christie Nhs Foundation Trust","Manchester Greater","M204BX",{"type":751,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[753,756],{"name":754,"class":755},"ENGOT Foundation","UNKNOWN",{"name":757,"class":758},"GOG Foundation","NETWORK","100594759","phase-2-a-study-of-incb123667-in-participants-with-platinum-resistant-ovarian-cancer-with-cyclin-e1-overexpression-100594759",false,"NCT07023627","A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression","A Phase 2, Single-Arm Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression (MAESTRA 1)","MAESTRA 1","Inclusion Criteria:\n\n* Histological diagnosis of a high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer.\n* Have platinum-resistant disease:\n\n  * Participants who have only had 1 line of platinum-based therapy must have received at least 4 cycles of a platinum-containing regimen.\n  * Participants who have received 2 to 4 lines of platinum-based therapy must have progressed on or within 6 months after the last dose of platinum.\n* Willingness to undergo a pretreatment biopsy. Note: Tissue from a fresh pretreatment biopsy is preferred, however an archival sample is acceptable as long as the sample is no older than 5 years.\n* Received at least 1 and no more than 4 prior lines of systemic therapy following the initial diagnosis, after which single-agent therapy is considered an appropriate next therapeutic option.\n* Must have received bevacizumab unless there was a contraindication for its use.\n* If the tumor tests positive for FRα, participants must have received mirvetuximab soravtansine unless there is an exception for its use on medical grounds.\n\nExclusion Criteria:\n\n* Have endometrioid, clear cell, mucinous, or sarcomatous histology, mixed tumors containing any of these histologies, or low-grade\u002Fborderline ovarian cancer.\n* Have primary platinum-refractory disease: either did not respond (CR or PR) to first-line platinum-containing therapy or progressed on or within 3 months after the last dose of the first line platinum-containing therapy.\n* The tumor tests positive for FRα but the participant has not received mirvetuximab soravtansine for any reason other than medical contraindication.\n* Clinically significant or uncontrolled cardiac disease within 6 months before the first dose of study drug.\n* Known active CNS metastases and\u002For carcinomatous meningitis.\n* Known additional malignancy that is progressing or requires active treatment.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","FEMALE","18 Years","99 Years",{"count":771,"type":772},160,"ESTIMATED","INTERVENTIONAL",[775],"PHASE2","This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.",[778],"Ovarian Cancer",[23],"2026-05-29",{"date":782,"type":783},"2026-06-01","ACTUAL",{"date":785,"type":783},"2025-11-12",{"date":787,"type":772},"2027-10-24",{"name":5,"class":6},79]