[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544433":3},{"organization":4,"armGroups":7,"interventions":48,"overallOfficials":186,"centralContacts":171,"locations":190,"responsibleParty":1764,"collaborators":171,"id":1766,"slug":1767,"hasResults":1768,"nctId":1769,"briefTitle":1770,"officialTitle":1771,"acronym":171,"eligibilityCriteria":1772,"healthyVolunteers":1768,"sex":1773,"minAge":1774,"maxAge":1775,"enrollmentInfo":1776,"targetDuration":171,"studyType":1779,"phases":1780,"briefSummary":1782,"conditions":1783,"keywords":171,"overallStatus":193,"whyStopped":171,"lastUpdateSubmitDate":1790,"lastUpdatePostDateStruct":1791,"startDateStruct":1794,"completionDateStruct":1796,"leadSponsor":1798,"locationsCount":1799},{"fullName":5,"class":6},"Children's Oncology Group","NETWORK",[8,24,28,32,36,40,44],{"label":9,"type":10,"description":11,"interventionNames":12},"Stratum I (carboplatin, etoposide, 3D-CRT, IMRT, surgery)","EXPERIMENTAL","See Detailed Description.",[13,14,15,16,17,18,19,20,21,22,23],"Radiation: 3-Dimensional Conformal Proton Radiation Therapy","Radiation: 3-Dimensional Conformal Radiation Therapy","Procedure: Biospecimen Collection","Drug: Carboplatin","Drug: Etoposide","Procedure: Intensity-Modulated Proton Therapy","Radiation: Intensity-Modulated Radiation Therapy","Procedure: Lumbar Puncture","Procedure: Magnetic Resonance Imaging","Other: Questionnaire Administration","Procedure: Surgical Procedure",{"label":25,"type":10,"description":26,"interventionNames":27},"Stratum II (carboplatin, etoposide, 3D-CRT, IMRT)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with localized germinoma achieving PR with normalization of markers who do not undergo second-look surgery undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 20 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22],{"label":29,"type":10,"description":30,"interventionNames":31},"Stratum III (carboplatin, etoposide, 3D-CRT, IMRT)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with localized germinoma with normalization of markers who fail to achieve CR or PR who do not undergo second-look surgery undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 24 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22],{"label":33,"type":10,"description":34,"interventionNames":35},"Stratum IV (carboplatin, etoposide, 3D-CRT, IMRT, surgery)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with metastatic germinoma achieving CR undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 20 days. Patients with metastatic germinoma and normalization of markers who fail to achieve CR may undergo second-look surgery. Patients found to have mature teratoma or non-viable tumor undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 20 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22,23],{"label":37,"type":10,"description":38,"interventionNames":39},"Stratum V (carboplatin, etoposide, 3D-CRT, IMRT)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with metastatic germinoma with normalization of markers who fail to achieve CR who do not undergo second-look surgery undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 24 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22],{"label":41,"type":10,"description":42,"interventionNames":43},"Stratum VI (carboplatin, etoposide, 3D-CRT, IMRT, surgery)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with basal ganglia and thalamic germinoma achieving CR undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 20 days. Patients with basal ganglia and thalamic germinoma and normalization of markers who fail to achieve CR may undergo second-look surgery. Patients found to have mature teratoma or non-viable tumor undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 20 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22,23],{"label":45,"type":10,"description":46,"interventionNames":47},"Stratum VII (carboplatin, etoposide, 3D-CRT, IMRT)","Patients receive carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of each cycle. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients with basal ganglia and thalamic germinoma with normalization of markers who fail to achieve CR who do not undergo second-look surgery undergo 3D-CRT\u002F3D-CPRT or IMRT\u002FIMPT QD 5 days a week for 24 days. Patients undergo MRI and optional blood and tissue sample collection throughout the study. Patients may undergo LP for CSF sample collection during screening and follow up.",[13,14,15,16,17,18,19,20,21,22],[49,56,71,80,106,123,129,139,146,166,172],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"RADIATION","3-Dimensional Conformal Proton Radiation Therapy","Undergo 3D-CPRT",[9,25,29,33,37,41,45],[55],"3D-CPRT",{"type":50,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"3-Dimensional Conformal Radiation Therapy","Undergo 3D-CRT",[9,25,29,33,37,41,45],[61,62,63,64,65,66,67,68,69,70],"3-dimensional radiation therapy","3D Conformal","3D CONFORMAL RADIATION THERAPY","3D CRT","3D radiotherapy","3D-CRT","Conformal Therapy","Radiation Conformal Therapy","Radiation, 3D Conformal","Three dimensional external beam radiation therapy (procedure)",{"type":72,"name":73,"description":74,"armGroupLabels":75,"otherNames":76},"PROCEDURE","Biospecimen Collection","Undergo blood and CSF sample collection",[9,25,29,33,37,41,45],[77,78,79],"Biological 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Reddy",{"facility":287,"status":193,"city":288,"state":245,"zip":289,"country":197,"countryCode":198,"cosmosGeoPoint":290,"geoPoint":294,"contacts":295},"Children's Hospital of Orange County","Orange","92868",{"type":200,"coordinates":291},[292,293],-117.85311,33.78779,{"lat":293,"lon":292},[296,299],{"name":207,"role":208,"phone":297,"phoneExt":171,"email":298},"714-509-8646","oncresearch@choc.org",{"name":300,"role":189,"phone":171,"phoneExt":171,"email":171},"Elyssa M. Rubin",{"facility":302,"status":193,"city":303,"state":245,"zip":304,"country":197,"countryCode":198,"cosmosGeoPoint":305,"geoPoint":309,"contacts":310},"Lucile Packard Children's Hospital Stanford University","Palo Alto","94304",{"type":200,"coordinates":306},[307,308],-122.14302,37.44188,{"lat":308,"lon":307},[311,314],{"name":207,"role":208,"phone":312,"phoneExt":171,"email":313},"800-694-0012","ccto-office@stanford.edu",{"name":315,"role":189,"phone":171,"phoneExt":171,"email":171},"Jay Michael S. Balagtas",{"facility":317,"status":193,"city":318,"state":245,"zip":319,"country":197,"countryCode":198,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Rady Children's Hospital - San Diego","San Diego","92123",{"type":200,"coordinates":321},[322,323],-117.16472,32.71571,{"lat":323,"lon":322},[326,328],{"name":207,"role":208,"phone":327,"phoneExt":171,"email":171},"858-966-5934",{"name":329,"role":189,"phone":171,"phoneExt":171,"email":171},"William D. Roberts",{"facility":331,"status":193,"city":332,"state":245,"zip":333,"country":197,"countryCode":198,"cosmosGeoPoint":334,"geoPoint":338,"contacts":339},"UCSF Medical Center-Mission Bay","San Francisco","94158",{"type":200,"coordinates":335},[336,337],-122.41942,37.77493,{"lat":337,"lon":336},[340,343],{"name":207,"role":208,"phone":341,"phoneExt":171,"email":342},"877-827-3222","cancertrials@ucsf.edu",{"name":285,"role":189,"phone":171,"phoneExt":171,"email":171},{"facility":345,"status":193,"city":346,"state":347,"zip":348,"country":197,"countryCode":198,"cosmosGeoPoint":349,"geoPoint":353,"contacts":354},"Children's Hospital Colorado","Aurora","Colorado","80045",{"type":200,"coordinates":350},[351,352],-104.83192,39.72943,{"lat":352,"lon":351},[355,358],{"name":207,"role":208,"phone":356,"phoneExt":171,"email":357},"303-764-5056","josh.b.gordon@nsmtp.kp.org",{"name":359,"role":189,"phone":171,"phoneExt":171,"email":171},"Holly B. Lindsay",{"facility":361,"status":193,"city":362,"state":363,"zip":364,"country":197,"countryCode":198,"cosmosGeoPoint":365,"geoPoint":369,"contacts":370},"Connecticut Children's Medical Center","Hartford","Connecticut","06106",{"type":200,"coordinates":366},[367,368],-72.68509,41.76371,{"lat":368,"lon":367},[371,373],{"name":207,"role":208,"phone":372,"phoneExt":171,"email":171},"860-545-9981",{"name":374,"role":189,"phone":171,"phoneExt":171,"email":171},"Michael S. Isakoff",{"facility":376,"status":193,"city":377,"state":378,"zip":379,"country":197,"countryCode":198,"cosmosGeoPoint":380,"geoPoint":384,"contacts":385},"Alfred I duPont Hospital for Children","Wilmington","Delaware","19803",{"type":200,"coordinates":381},[382,383],-75.54659,39.74595,{"lat":383,"lon":382},[386,389],{"name":207,"role":208,"phone":387,"phoneExt":171,"email":388},"302-651-5572","Allison.bruce@nemours.org",{"name":390,"role":189,"phone":171,"phoneExt":171,"email":171},"Sridhi Patel",{"facility":392,"status":193,"city":393,"state":394,"zip":395,"country":197,"countryCode":198,"cosmosGeoPoint":396,"geoPoint":400,"contacts":401},"Children's National Medical Center","Washington D.C.","District of Columbia","20010",{"type":200,"coordinates":397},[398,399],-77.03637,38.89511,{"lat":399,"lon":398},[402,405],{"name":207,"role":208,"phone":403,"phoneExt":171,"email":404},"202-476-2800","OncCRC_OnCall@childrensnational.org",{"name":406,"role":189,"phone":171,"phoneExt":171,"email":171},"Jeffrey S. Dome",{"facility":408,"status":193,"city":409,"state":410,"zip":411,"country":197,"countryCode":198,"cosmosGeoPoint":412,"geoPoint":416,"contacts":417},"Memorial Regional Hospital\u002FJoe DiMaggio Children's Hospital","Hollywood","Florida","33021",{"type":200,"coordinates":413},[414,415],-80.14949,26.0112,{"lat":415,"lon":414},[418,421],{"name":207,"role":208,"phone":419,"phoneExt":171,"email":420},"954-265-1847","OHR@mhs.net",{"name":422,"role":189,"phone":171,"phoneExt":171,"email":171},"Iftikhar Hanif",{"facility":424,"status":193,"city":425,"state":410,"zip":426,"country":197,"countryCode":198,"cosmosGeoPoint":427,"geoPoint":431,"contacts":432},"Nemours Children's Clinic-Jacksonville","Jacksonville","32207",{"type":200,"coordinates":428},[429,430],-81.65565,30.33218,{"lat":430,"lon":429},[433,434],{"name":207,"role":208,"phone":387,"phoneExt":171,"email":388},{"name":390,"role":189,"phone":171,"phoneExt":171,"email":171},{"facility":436,"status":193,"city":437,"state":410,"zip":438,"country":197,"countryCode":198,"cosmosGeoPoint":439,"geoPoint":443,"contacts":444},"University of Miami Miller School of Medicine-Sylvester Cancer Center","Miami","33136",{"type":200,"coordinates":440},[441,442],-80.19366,25.77427,{"lat":442,"lon":441},[445,447],{"name":207,"role":208,"phone":446,"phoneExt":171,"email":171},"305-243-2647",{"name":448,"role":189,"phone":171,"phoneExt":171,"email":171},"Bradley Gampel",{"facility":450,"status":193,"city":437,"state":410,"zip":451,"country":197,"countryCode":198,"cosmosGeoPoint":452,"geoPoint":454,"contacts":455},"Nicklaus Children's Hospital","33155",{"type":200,"coordinates":453},[441,442],{"lat":442,"lon":441},[456,458],{"name":207,"role":208,"phone":457,"phoneExt":171,"email":171},"888-624-2778",{"name":459,"role":189,"phone":171,"phoneExt":171,"email":171},"Ziad A. Khatib",{"facility":461,"status":193,"city":462,"state":410,"zip":463,"country":197,"countryCode":198,"cosmosGeoPoint":464,"geoPoint":468,"contacts":469},"Arnold Palmer Hospital for Children","Orlando","32806",{"type":200,"coordinates":465},[466,467],-81.37924,28.53834,{"lat":467,"lon":466},[470,473],{"name":207,"role":208,"phone":471,"phoneExt":171,"email":472},"321-841-5357","Jennifer.spinelli@orlandohealth.com",{"name":474,"role":189,"phone":171,"phoneExt":171,"email":171},"Jaime M. Libes-Bander",{"facility":476,"status":193,"city":462,"state":410,"zip":477,"country":197,"countryCode":198,"cosmosGeoPoint":478,"geoPoint":480,"contacts":481},"Nemours Children's Hospital","32827",{"type":200,"coordinates":479},[466,467],{"lat":467,"lon":466},[482,483],{"name":207,"role":208,"phone":387,"phoneExt":171,"email":388},{"name":390,"role":189,"phone":171,"phoneExt":171,"email":171},{"facility":485,"status":193,"city":486,"state":410,"zip":487,"country":197,"countryCode":198,"cosmosGeoPoint":488,"geoPoint":492,"contacts":493},"Nemours Children's Clinic - Pensacola","Pensacola","32504",{"type":200,"coordinates":489},[490,491],-87.21691,30.42131,{"lat":491,"lon":490},[494,496],{"name":207,"role":208,"phone":171,"phoneExt":171,"email":495},"helpdesk@childrensoncologygroup.org",{"name":497,"role":189,"phone":171,"phoneExt":171,"email":171},"Jeffrey H. Schwartz",{"facility":499,"status":500,"city":486,"state":410,"zip":487,"country":197,"countryCode":198,"cosmosGeoPoint":501,"geoPoint":503,"contacts":171},"Sacred Heart Hospital","ACTIVE_NOT_RECRUITING",{"type":200,"coordinates":502},[490,491],{"lat":491,"lon":490},{"facility":505,"status":193,"city":506,"state":410,"zip":507,"country":197,"countryCode":198,"cosmosGeoPoint":508,"geoPoint":512,"contacts":513},"Johns Hopkins All Children's Hospital","St. Petersburg","33701",{"type":200,"coordinates":509},[510,511],-82.67927,27.77086,{"lat":511,"lon":510},[514,517],{"name":207,"role":208,"phone":515,"phoneExt":171,"email":516},"727-767-4784","Ashley.Repp@jhmi.edu",{"name":518,"role":189,"phone":171,"phoneExt":171,"email":171},"Stacie L. Stapleton",{"facility":520,"status":193,"city":521,"state":410,"zip":522,"country":197,"countryCode":198,"cosmosGeoPoint":523,"geoPoint":527,"contacts":528},"Saint Joseph's Hospital\u002FChildren's Hospital-Tampa","Tampa","33607",{"type":200,"coordinates":524},[525,526],-82.45843,27.94752,{"lat":526,"lon":525},[529,532],{"name":207,"role":208,"phone":530,"phoneExt":171,"email":531},"813-357-0849","jennifer.manns@baycare.org",{"name":533,"role":189,"phone":171,"phoneExt":171,"email":171},"Don E. 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No histologic confirmation required\n* Patients with EITHER (A) bifocal (pineal + suprasellar) involvement OR (B) pineal lesion with diabetes insipidus (DI) AND hCGbeta ≤ 100 mIU\u002FmL in serum and\u002For CSF AND institutional normal AFP (or ≤ 10 ng\u002FmL if no institutional normal exists) in both serum and CSF. No histologic confirmation required\n* Patients with hCGbeta 51-100 mIU\u002FmL in serum and\u002For CSF and institutional normal AFP (or ≤ 10 ng\u002FmL if no institutional normal exists) in both serum and CSF. Histologic confirmation of germinoma IS required\n* Patients with germinoma of the basal ganglia and or\u002Fthalamic primary sites are eligible\n* Patients with metastatic germinoma including non-contiguous disease or distant disease in the brain, ventricles, or spine are eligible\n* Patients with germinoma admixed with mature teratoma are eligible\n* Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2. Use Karnofsky for patients \\> 16 years of age and Lansky for patients ≤ 16 years of age\n* Patients must have eligibility confirmed by Rapid Central Imaging Review performed on APEC14B1-CNS\n* Imaging studies must be obtained within 31 days prior to study enrollment and start of protocol therapy. (Note: for patients that have had surgery and post-operative imaging performed, it is the post-operative MRI that must be obtained within 31 days prior to enrollment.)\n* Patients must have a cranial magnetic resonance imaging (MRI) with and without gadolinium at diagnosis\u002Fprior to enrollment. If surgical resection is performed, patients must have pre-operative and post-operative brain MRI with and without gadolinium. The post-operative brain MRI should be obtained within 72 hours of surgery. If patient has a biopsy only, post-operative brain MRI is recommended but not required\n* Patients must have a spine MRI with gadolinium obtained at diagnosis\u002Fprior to enrollment\n* Patients must be enrolled, and protocol therapy must begin, no later than 31 days after definitive surgery or clinical diagnosis, whichever is later\n* Patients must have eligibility confirmed by Rapid Central Tumor Marker Review performed on APEC14B1-CNS\n* Lumbar CSF must be obtained prior to study enrollment unless medically contraindicated. If a patient undergoes surgery and lumbar CSF cytology cannot be obtained at the time of surgery, then it should be performed at least 10 days following surgery and prior to study enrollment. False positive cytology can occur within 10 days of surgery. Of note, lumbar CSF should not be performed prior to obtaining spine MRI, as this can make interpretation of the spine MRI less clear\n* Patients must have CSF tumor markers obtained prior to study enrollment unless medically contraindicated. Ventricular CSF obtained at the time of CSF diversion procedure (if performed) is acceptable for tumor markers but lumbar CSF is preferred. In case CSF diversion and biopsy\u002Fsurgery are combined, CSF tumor markers should be collected first. Ideally serum and CSF tumor markers should be collected at the same time and processed without delay\n* For patients with solid tumors: Peripheral absolute neutrophil count (ANC) \\>= 1000\u002FuL (Must be performed within 7 days prior to enrollment unless otherwise indicated)\n* For patients with solid tumors: Platelet count \\>= 100,000\u002FuL (transfusion independent) (Must be performed within 7 days prior to enrollment unless otherwise indicated)\n* For patients with solid tumors: Hemoglobin \\>= 8.0 g\u002FdL (may receive red blood cell \\[RBC\\] transfusions) (Must be performed within 7 days prior to enrollment unless otherwise indicated)\n* For pediatric patients (age 3-17 years): A serum creatinine based on age\u002Fsex as follows (Must be performed within 7 days prior to enrollment unless otherwise indicated):\n\n  * Age: 3 to \\\u003C 6 years; maximum serum creatinine (mg\u002FdL): 0.8 (male); 0.8 (female)\n  * Age: 6 to \\\u003C 10 years; maximum serum creatinine (mg\u002FdL): 1 (male); 1 (female)\n  * Age: 10 to \\\u003C 13 years; maximum serum creatinine (mg\u002FdL): 1.2 (male); 1.2 (female)\n  * Age: 13 to \\\u003C 16 years; maximum serum creatinine (mg\u002FdL): 1.5 (male); 1.4 (female)\n  * Age: ≥ 17 years; maximum serum creatinine (mg\u002FdL): 1.7 (male); 1.4 (female) OR a 24-hour urine creatinine clearance ≥ 70 mL\u002Fmin\u002F1.73 m\\^2 OR a glomerular filtration rate (GFR) ≥ 50 mL\u002Fmin\u002F1.73 m\\^2. GFR must be performed using direct measurement with a nuclear blood sampling method OR direct small molecule clearance method (iothalamate or other molecule per institutional standard).\n  * Note: Estimated GFR (eGFR) from serum or plasma creatinine, cystatin C or other estimates are not acceptable for determining eligibility.\n  * For adult patients (age 18 years or older) (Must be performed within 7 days prior to enrollment unless otherwise indicated):\n\n    * Creatinine clearance ≥ 70 mL\u002Fmin, as estimated by the Cockcroft and Gault formula or a 24-hour urine collection. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on actual body weight\n* Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age (Must be performed within 7 days prior to enrollment unless otherwise indicated)\n* Serum glutamic-pyruvic transaminase (SGPT) (alanine transaminase \\[ALT\\]) ≤ 135 U\u002FL (Must be performed within 7 days prior to enrollment unless otherwise indicated)\n\n  * Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U\u002FL\n* No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry \\> 94% if there is clinical indication for determination\n* Patients with seizure disorder may be enrolled if on anticonvulsants and well controlled\n* CNS toxicity =\\\u003C grade 2\n* Patients must not be in status epilepticus, coma or assisted ventilation prior to study enrollment\n* HIV-infected patients on effective anti-retroviral therapy with undetectable viral load are eligible for this study\n\nExclusion Criteria:\n\n* Patients with any of the following malignant pathological elements are not eligible:\n\n  * Endodermal sinus (yolk sac)\n  * Embryonal carcinoma, choriocarcinoma\n  * Malignant\u002Fimmature teratoma and mixed germ cell tumor (GCT) (i.e., may include some germinoma)\n* Patients with only mature teratoma upon tumor sampling at diagnosis and negative tumor markers are not eligible\n* Patients who have received any prior tumor-directed therapy for their diagnosis of germinoma other than surgical intervention and corticosteroids are not eligible\n* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential.\n\n  * Note: Serum and urine pregnancy tests may be falsely positive due to HCGbeta-secreting germ cell tumors. Ensure the patient is not pregnant by institutional standards\n* Lactating females who plan to breastfeed their infants\n* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation\n* All patients and\u002For their parents or legal guardians must sign a written informed consent\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met","ALL","3 Years","29 Years",{"count":1777,"type":1778},240,"ESTIMATED","INTERVENTIONAL",[1781],"PHASE2","This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \\& Etoposide) works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Researchers want to see if lowering the dose of standard radiotherapy (RT) after chemotherapy can help get rid of CNS germinomas with fewer long-term side effects.",[1784,1785,1786,1787,1788,1789],"Basal Ganglia Germinoma","Diabetes Insipidus","Germinoma","Pineal Region Germinoma","Suprasellar Germinoma","Thalamic Germinoma","2026-04-28",{"date":1792,"type":1793},"2026-05-04","ACTUAL",{"date":1795,"type":1793},"2024-10-22",{"date":1797,"type":1778},"2033-11-04",{"name":5,"class":6},109]