[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598301":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":51,"centralContacts":60,"locations":66,"responsibleParty":608,"collaborators":610,"id":613,"slug":614,"hasResults":615,"nctId":616,"briefTitle":617,"officialTitle":618,"acronym":51,"eligibilityCriteria":619,"healthyVolunteers":615,"sex":620,"minAge":621,"maxAge":51,"enrollmentInfo":622,"targetDuration":51,"studyType":625,"phases":626,"briefSummary":628,"conditions":629,"keywords":631,"overallStatus":69,"whyStopped":51,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":647,"locationsCount":648},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,17,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Sub-study 1: AZD0901 plus Rilvegostomig and 5-FU or Capecitabine","EXPERIMENTAL","Participants will receive AZD0901 plus Rilvegostomig and 5-FU or Capecitabine as neoadjuvant combination therapy (pre-surgery period) and adjuvant combination therapy (post-surgery period) and later will receive Rilvegostomig as adjuvant monotherapy.",[13,14,15,16],"Drug: AZD0901","Drug: Rilvegostomig","Drug: Capecitabine","Drug: 5-Fluorouracil (5-FU)",{"label":18,"type":10,"description":19,"interventionNames":20},"Sub-study 2: T-DXd plus Rilvegostomig and 5-FU or Capecitabine","Participants will receive T-DXd plus Rilvegostomig and 5-FU or Capecitabine as neoadjuvant combination therapy (pre-surgery period) and adjuvant combination therapy (post-surgery period) and later will receive Rilvegostomig as adjuvant monotherapy.",[14,21,15,16],"Drug: Trastuzumab Deruxtecan (T-DXd)",{"label":23,"type":10,"description":24,"interventionNames":25},"Sub-study 3: Rilvegostomig plus FLOT chemotherapy","Participants will receive Rilvegostomig plus FLOT chemotherapy as neoadjuvant combination therapy (pre-surgery period) and adjuvant combination therapy (post-surgery period) and later will receive Rilvegostomig as adjuvant monotherapy.",[14,26],"Drug: FLOT Chemotherapy",[28,35,41,47,52,56],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","AZD0901","AZD0901 will be administered as an IV infusion.",[9],[34],"Sonesitatug Vedotin",{"type":29,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Rilvegostomig","Rilvegostomig will be administered as an IV infusion.",[9,18,23],[40],"AZD2936",{"type":29,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"Trastuzumab Deruxtecan (T-DXd)","T-DXd will be administered as an IV infusion.",[18],[46],"DS-8201a",{"type":29,"name":48,"description":49,"armGroupLabels":50,"otherNames":51},"Capecitabine","Capecitabine (Fluoropyrimidine) will be administered orally as chemotherapy standard of care.",[9,18],null,{"type":29,"name":53,"description":54,"armGroupLabels":55,"otherNames":51},"5-Fluorouracil (5-FU)","5-FU (Fluoropyrimidine) will be administered as an IV infusion as chemotherapy standard of care.",[9,18],{"type":29,"name":57,"description":58,"armGroupLabels":59,"otherNames":51},"FLOT Chemotherapy","FLOT (5-FU, leucovorin, oxaliplatin, and docetaxel) Chemotherapy will be administered as an IV infusion.",[23],[61],{"name":62,"role":63,"phone":64,"phoneExt":51,"email":65},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[67,81,90,99,108,117,122,131,143,152,157,167,175,183,191,196,204,212,217,225,233,241,250,260,265,270,275,285,293,298,303,311,319,327,335,343,353,361,364,372,375,383,391,399,404,407,415,425,433,443,448,456,464,472,480,488,496,504,514,522,530,538,547,555,558,566,576,584,592,600],{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":51},"Research Site","RECRUITING","Newark","Delaware","19713","United States","US",{"type":76,"coordinates":77},"Point",[78,79],-75.74966,39.68372,{"lat":79,"lon":78},{"facility":68,"status":69,"city":82,"state":83,"zip":84,"country":73,"countryCode":74,"cosmosGeoPoint":85,"geoPoint":89,"contacts":51},"Washington D.C.","District of Columbia","20007",{"type":76,"coordinates":86},[87,88],-77.03637,38.89511,{"lat":88,"lon":87},{"facility":68,"status":69,"city":91,"state":92,"zip":93,"country":73,"countryCode":74,"cosmosGeoPoint":94,"geoPoint":98,"contacts":51},"Fairway","Kansas","66205",{"type":76,"coordinates":95},[96,97],-94.6319,39.02223,{"lat":97,"lon":96},{"facility":68,"status":69,"city":100,"state":101,"zip":102,"country":73,"countryCode":74,"cosmosGeoPoint":103,"geoPoint":107,"contacts":51},"North Shores","Michigan","49444",{"type":76,"coordinates":104},[105,106],-83.40743,41.83643,{"lat":106,"lon":105},{"facility":68,"status":109,"city":110,"state":110,"zip":111,"country":73,"countryCode":74,"cosmosGeoPoint":112,"geoPoint":116,"contacts":51},"NOT_YET_RECRUITING","New York","10032",{"type":76,"coordinates":113},[114,115],-74.00597,40.71427,{"lat":115,"lon":114},{"facility":68,"status":69,"city":110,"state":110,"zip":118,"country":73,"countryCode":74,"cosmosGeoPoint":119,"geoPoint":121,"contacts":51},"10065",{"type":76,"coordinates":120},[114,115],{"lat":115,"lon":114},{"facility":68,"status":109,"city":123,"state":124,"zip":125,"country":73,"countryCode":74,"cosmosGeoPoint":126,"geoPoint":130,"contacts":51},"Pittsburgh","Pennsylvania","15232",{"type":76,"coordinates":127},[128,129],-79.99589,40.44062,{"lat":129,"lon":128},{"facility":68,"status":132,"city":133,"state":134,"zip":135,"country":136,"countryCode":137,"cosmosGeoPoint":138,"geoPoint":142,"contacts":51},"SUSPENDED","Toronto","Ontario","M5G 2M9","Canada","CA",{"type":76,"coordinates":139},[140,141],-79.39864,43.70643,{"lat":141,"lon":140},{"facility":68,"status":69,"city":144,"state":145,"zip":146,"country":136,"countryCode":137,"cosmosGeoPoint":147,"geoPoint":151,"contacts":51},"Montreal","Quebec","H2X 3E4",{"type":76,"coordinates":148},[149,150],-73.58781,45.50884,{"lat":150,"lon":149},{"facility":68,"status":69,"city":144,"state":145,"zip":153,"country":136,"countryCode":137,"cosmosGeoPoint":154,"geoPoint":156,"contacts":51},"H4A 3J1",{"type":76,"coordinates":155},[149,150],{"lat":150,"lon":149},{"facility":68,"status":69,"city":158,"state":51,"zip":159,"country":160,"countryCode":161,"cosmosGeoPoint":162,"geoPoint":166,"contacts":51},"Beijing","100142","China","CN",{"type":76,"coordinates":163},[164,165],116.39723,39.9075,{"lat":165,"lon":164},{"facility":68,"status":69,"city":168,"state":51,"zip":169,"country":160,"countryCode":161,"cosmosGeoPoint":170,"geoPoint":174,"contacts":51},"Changchun","130021",{"type":76,"coordinates":171},[172,173],125.32278,43.88,{"lat":173,"lon":172},{"facility":68,"status":69,"city":176,"state":51,"zip":177,"country":160,"countryCode":161,"cosmosGeoPoint":178,"geoPoint":182,"contacts":51},"Changzhi","046000",{"type":76,"coordinates":179},[180,181],113.10528,36.18389,{"lat":181,"lon":180},{"facility":68,"status":69,"city":184,"state":51,"zip":185,"country":160,"countryCode":161,"cosmosGeoPoint":186,"geoPoint":190,"contacts":51},"Chengdu","610041",{"type":76,"coordinates":187},[188,189],104.06667,30.66667,{"lat":189,"lon":188},{"facility":68,"status":69,"city":184,"state":51,"zip":192,"country":160,"countryCode":161,"cosmosGeoPoint":193,"geoPoint":195,"contacts":51},"610042",{"type":76,"coordinates":194},[188,189],{"lat":189,"lon":188},{"facility":68,"status":109,"city":197,"state":51,"zip":198,"country":160,"countryCode":161,"cosmosGeoPoint":199,"geoPoint":203,"contacts":51},"Fuzhou","350014",{"type":76,"coordinates":200},[201,202],119.30611,26.06139,{"lat":202,"lon":201},{"facility":68,"status":69,"city":205,"state":51,"zip":206,"country":160,"countryCode":161,"cosmosGeoPoint":207,"geoPoint":211,"contacts":51},"Hangzhou","310003",{"type":76,"coordinates":208},[209,210],120.16142,30.29365,{"lat":210,"lon":209},{"facility":68,"status":69,"city":205,"state":51,"zip":213,"country":160,"countryCode":161,"cosmosGeoPoint":214,"geoPoint":216,"contacts":51},"310014",{"type":76,"coordinates":215},[209,210],{"lat":210,"lon":209},{"facility":68,"status":69,"city":218,"state":51,"zip":219,"country":160,"countryCode":161,"cosmosGeoPoint":220,"geoPoint":224,"contacts":51},"Kunming","650118",{"type":76,"coordinates":221},[222,223],102.71833,25.03889,{"lat":223,"lon":222},{"facility":68,"status":69,"city":226,"state":51,"zip":227,"country":160,"countryCode":161,"cosmosGeoPoint":228,"geoPoint":232,"contacts":51},"Qingdao","266003",{"type":76,"coordinates":229},[230,231],120.38042,36.06488,{"lat":231,"lon":230},{"facility":68,"status":69,"city":234,"state":51,"zip":235,"country":160,"countryCode":161,"cosmosGeoPoint":236,"geoPoint":240,"contacts":51},"Shanghai","200025",{"type":76,"coordinates":237},[238,239],121.45806,31.22222,{"lat":239,"lon":238},{"facility":68,"status":242,"city":243,"state":51,"zip":244,"country":160,"countryCode":161,"cosmosGeoPoint":245,"geoPoint":249,"contacts":51},"WITHDRAWN","Shijiazhuang","050020",{"type":76,"coordinates":246},[247,248],114.47861,38.04139,{"lat":248,"lon":247},{"facility":68,"status":69,"city":251,"state":51,"zip":252,"country":253,"countryCode":254,"cosmosGeoPoint":255,"geoPoint":259,"contacts":51},"Tbilisi","0112","Georgia","GE",{"type":76,"coordinates":256},[257,258],44.83412,41.69143,{"lat":258,"lon":257},{"facility":68,"status":69,"city":251,"state":51,"zip":261,"country":253,"countryCode":254,"cosmosGeoPoint":262,"geoPoint":264,"contacts":51},"0114",{"type":76,"coordinates":263},[257,258],{"lat":258,"lon":257},{"facility":68,"status":69,"city":251,"state":51,"zip":266,"country":253,"countryCode":254,"cosmosGeoPoint":267,"geoPoint":269,"contacts":51},"0144",{"type":76,"coordinates":268},[257,258],{"lat":258,"lon":257},{"facility":68,"status":69,"city":251,"state":51,"zip":271,"country":253,"countryCode":254,"cosmosGeoPoint":272,"geoPoint":274,"contacts":51},"0159",{"type":76,"coordinates":273},[257,258],{"lat":258,"lon":257},{"facility":68,"status":69,"city":276,"state":51,"zip":277,"country":278,"countryCode":279,"cosmosGeoPoint":280,"geoPoint":284,"contacts":51},"Florence","50134","Italy","IT",{"type":76,"coordinates":281},[282,283],11.24626,43.77925,{"lat":283,"lon":282},{"facility":68,"status":69,"city":286,"state":51,"zip":287,"country":278,"countryCode":279,"cosmosGeoPoint":288,"geoPoint":292,"contacts":51},"Milan","20133",{"type":76,"coordinates":289},[290,291],12.59836,42.78235,{"lat":291,"lon":290},{"facility":68,"status":69,"city":286,"state":51,"zip":294,"country":278,"countryCode":279,"cosmosGeoPoint":295,"geoPoint":297,"contacts":51},"20141",{"type":76,"coordinates":296},[290,291],{"lat":291,"lon":290},{"facility":68,"status":69,"city":286,"state":51,"zip":299,"country":278,"countryCode":279,"cosmosGeoPoint":300,"geoPoint":302,"contacts":51},"20162",{"type":76,"coordinates":301},[290,291],{"lat":291,"lon":290},{"facility":68,"status":242,"city":304,"state":51,"zip":305,"country":278,"countryCode":279,"cosmosGeoPoint":306,"geoPoint":310,"contacts":51},"Modena","41124",{"type":76,"coordinates":307},[308,309],10.92539,44.64783,{"lat":309,"lon":308},{"facility":68,"status":69,"city":312,"state":51,"zip":313,"country":278,"countryCode":279,"cosmosGeoPoint":314,"geoPoint":318,"contacts":51},"Pisa","56100",{"type":76,"coordinates":315},[316,317],10.4036,43.70853,{"lat":317,"lon":316},{"facility":68,"status":69,"city":320,"state":51,"zip":321,"country":278,"countryCode":279,"cosmosGeoPoint":322,"geoPoint":326,"contacts":51},"Rozzano","20089",{"type":76,"coordinates":323},[324,325],9.1559,45.38193,{"lat":325,"lon":324},{"facility":68,"status":109,"city":328,"state":51,"zip":329,"country":278,"countryCode":279,"cosmosGeoPoint":330,"geoPoint":334,"contacts":51},"Udine","33100",{"type":76,"coordinates":331},[332,333],13.23715,46.0693,{"lat":333,"lon":332},{"facility":68,"status":69,"city":336,"state":51,"zip":337,"country":278,"countryCode":279,"cosmosGeoPoint":338,"geoPoint":342,"contacts":51},"Vicenza","36100",{"type":76,"coordinates":339},[340,341],11.5475,45.54672,{"lat":341,"lon":340},{"facility":68,"status":69,"city":344,"state":51,"zip":345,"country":346,"countryCode":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":51},"Chūōku","104-0045","Japan","JP",{"type":76,"coordinates":349},[350,351],130.67068,33.63867,{"lat":351,"lon":350},{"facility":68,"status":69,"city":354,"state":51,"zip":355,"country":346,"countryCode":347,"cosmosGeoPoint":356,"geoPoint":360,"contacts":51},"Fukuoka","812-8582",{"type":76,"coordinates":357},[358,359],130.41667,33.6,{"lat":359,"lon":358},{"facility":68,"status":69,"city":362,"state":51,"zip":363,"country":346,"countryCode":347,"cosmosGeoPoint":51,"geoPoint":51,"contacts":51},"Hidaka-shi","350-1298",{"facility":68,"status":69,"city":365,"state":51,"zip":366,"country":346,"countryCode":347,"cosmosGeoPoint":367,"geoPoint":371,"contacts":51},"Kashiwa","277-8577",{"type":76,"coordinates":368},[369,370],139.97732,35.86224,{"lat":370,"lon":369},{"facility":68,"status":69,"city":373,"state":51,"zip":374,"country":346,"countryCode":347,"cosmosGeoPoint":51,"geoPoint":51,"contacts":51},"Kitaadachi-gun","362-0806",{"facility":68,"status":69,"city":376,"state":51,"zip":377,"country":346,"countryCode":347,"cosmosGeoPoint":378,"geoPoint":382,"contacts":51},"Kōtoku","135-8550",{"type":76,"coordinates":379},[380,381],143.14297,42.50417,{"lat":381,"lon":380},{"facility":68,"status":69,"city":384,"state":51,"zip":385,"country":346,"countryCode":347,"cosmosGeoPoint":386,"geoPoint":390,"contacts":51},"Nagoya","464-8681",{"type":76,"coordinates":387},[388,389],136.90641,35.18147,{"lat":389,"lon":388},{"facility":68,"status":69,"city":392,"state":51,"zip":393,"country":346,"countryCode":347,"cosmosGeoPoint":394,"geoPoint":398,"contacts":51},"Osaka","541-8567",{"type":76,"coordinates":395},[396,397],135.50107,34.69379,{"lat":397,"lon":396},{"facility":68,"status":242,"city":392,"state":51,"zip":400,"country":346,"countryCode":347,"cosmosGeoPoint":401,"geoPoint":403,"contacts":51},"558-8558",{"type":76,"coordinates":402},[396,397],{"lat":397,"lon":396},{"facility":68,"status":69,"city":405,"state":51,"zip":406,"country":346,"countryCode":347,"cosmosGeoPoint":51,"geoPoint":51,"contacts":51},"Suita-shi","565-0871",{"facility":68,"status":69,"city":408,"state":51,"zip":409,"country":346,"countryCode":347,"cosmosGeoPoint":410,"geoPoint":414,"contacts":51},"Yokohama","241-8515",{"type":76,"coordinates":411},[412,413],139.65,35.43333,{"lat":413,"lon":412},{"facility":68,"status":242,"city":416,"state":51,"zip":417,"country":418,"countryCode":419,"cosmosGeoPoint":420,"geoPoint":424,"contacts":51},"Bialystok","15-027","Poland","PL",{"type":76,"coordinates":421},[422,423],23.16433,53.13333,{"lat":423,"lon":422},{"facility":68,"status":242,"city":426,"state":51,"zip":427,"country":418,"countryCode":419,"cosmosGeoPoint":428,"geoPoint":432,"contacts":51},"Warsaw","02-034",{"type":76,"coordinates":429},[430,431],21.01178,52.22977,{"lat":431,"lon":430},{"facility":68,"status":69,"city":434,"state":51,"zip":435,"country":436,"countryCode":437,"cosmosGeoPoint":438,"geoPoint":442,"contacts":51},"Barcelona","08035","Spain","ES",{"type":76,"coordinates":439},[440,441],2.15899,41.38879,{"lat":441,"lon":440},{"facility":68,"status":69,"city":434,"state":51,"zip":444,"country":436,"countryCode":437,"cosmosGeoPoint":445,"geoPoint":447,"contacts":51},"08036",{"type":76,"coordinates":446},[440,441],{"lat":441,"lon":440},{"facility":68,"status":69,"city":449,"state":51,"zip":450,"country":436,"countryCode":437,"cosmosGeoPoint":451,"geoPoint":455,"contacts":51},"Elche","03203",{"type":76,"coordinates":452},[453,454],-0.70107,38.26218,{"lat":454,"lon":453},{"facility":68,"status":69,"city":457,"state":51,"zip":458,"country":436,"countryCode":437,"cosmosGeoPoint":459,"geoPoint":463,"contacts":51},"Madrid","28007",{"type":76,"coordinates":460},[461,462],-3.70256,40.4165,{"lat":462,"lon":461},{"facility":68,"status":69,"city":465,"state":51,"zip":466,"country":436,"countryCode":437,"cosmosGeoPoint":467,"geoPoint":471,"contacts":51},"Málaga","29010",{"type":76,"coordinates":468},[469,470],-4.42034,36.72016,{"lat":470,"lon":469},{"facility":68,"status":69,"city":473,"state":51,"zip":474,"country":436,"countryCode":437,"cosmosGeoPoint":475,"geoPoint":479,"contacts":51},"Ourense","32005",{"type":76,"coordinates":476},[477,478],-7.86407,42.33669,{"lat":478,"lon":477},{"facility":68,"status":69,"city":481,"state":51,"zip":482,"country":436,"countryCode":437,"cosmosGeoPoint":483,"geoPoint":487,"contacts":51},"Oviedo","33011",{"type":76,"coordinates":484},[485,486],-5.84476,43.36029,{"lat":486,"lon":485},{"facility":68,"status":69,"city":489,"state":51,"zip":490,"country":436,"countryCode":437,"cosmosGeoPoint":491,"geoPoint":495,"contacts":51},"Santander","39008",{"type":76,"coordinates":492},[493,494],-3.80493,43.46589,{"lat":494,"lon":493},{"facility":68,"status":69,"city":497,"state":51,"zip":498,"country":436,"countryCode":437,"cosmosGeoPoint":499,"geoPoint":503,"contacts":51},"Valencia","46010",{"type":76,"coordinates":500},[501,502],-0.37966,39.47391,{"lat":502,"lon":501},{"facility":68,"status":69,"city":505,"state":51,"zip":506,"country":507,"countryCode":508,"cosmosGeoPoint":509,"geoPoint":513,"contacts":51},"Kaohsiung City","80756","Taiwan","TW",{"type":76,"coordinates":510},[511,512],120.31333,22.61626,{"lat":512,"lon":511},{"facility":68,"status":69,"city":515,"state":51,"zip":516,"country":507,"countryCode":508,"cosmosGeoPoint":517,"geoPoint":521,"contacts":51},"Tainan","704",{"type":76,"coordinates":518},[519,520],120.21333,22.99083,{"lat":520,"lon":519},{"facility":68,"status":69,"city":523,"state":51,"zip":524,"country":507,"countryCode":508,"cosmosGeoPoint":525,"geoPoint":529,"contacts":51},"Taipei","11217",{"type":76,"coordinates":526},[527,528],121.52639,25.05306,{"lat":528,"lon":527},{"facility":68,"status":69,"city":531,"state":51,"zip":532,"country":507,"countryCode":508,"cosmosGeoPoint":533,"geoPoint":537,"contacts":51},"Taoyuan","33305",{"type":76,"coordinates":534},[535,536],121.29696,24.99368,{"lat":536,"lon":535},{"facility":68,"status":242,"city":539,"state":51,"zip":540,"country":541,"countryCode":51,"cosmosGeoPoint":542,"geoPoint":546,"contacts":51},"Adapazarı","54100","Turkey (Türkiye)",{"type":76,"coordinates":543},[544,545],30.40333,40.78056,{"lat":545,"lon":544},{"facility":68,"status":242,"city":548,"state":51,"zip":549,"country":541,"countryCode":51,"cosmosGeoPoint":550,"geoPoint":554,"contacts":51},"Erzurum","25240",{"type":76,"coordinates":551},[552,553],41.27694,39.90861,{"lat":553,"lon":552},{"facility":68,"status":242,"city":556,"state":51,"zip":557,"country":541,"countryCode":51,"cosmosGeoPoint":51,"geoPoint":51,"contacts":51},"Fatih-Istanbul","34098",{"facility":68,"status":242,"city":559,"state":51,"zip":560,"country":541,"countryCode":51,"cosmosGeoPoint":561,"geoPoint":565,"contacts":51},"Istanbul","34722",{"type":76,"coordinates":562},[563,564],28.94966,41.01384,{"lat":564,"lon":563},{"facility":68,"status":242,"city":567,"state":51,"zip":568,"country":569,"countryCode":570,"cosmosGeoPoint":571,"geoPoint":575,"contacts":51},"Bristol","BS2 8ED","United Kingdom","UK",{"type":76,"coordinates":572},[573,574],-2.59665,51.45523,{"lat":574,"lon":573},{"facility":68,"status":69,"city":577,"state":51,"zip":578,"country":569,"countryCode":570,"cosmosGeoPoint":579,"geoPoint":583,"contacts":51},"Dundee","DD1 9SY",{"type":76,"coordinates":580},[581,582],-2.97489,56.46913,{"lat":582,"lon":581},{"facility":68,"status":69,"city":585,"state":51,"zip":586,"country":569,"countryCode":570,"cosmosGeoPoint":587,"geoPoint":591,"contacts":51},"Headington","OX3 7LJ",{"type":76,"coordinates":588},[589,590],-1.21974,51.75737,{"lat":590,"lon":589},{"facility":68,"status":109,"city":593,"state":51,"zip":594,"country":569,"countryCode":570,"cosmosGeoPoint":595,"geoPoint":599,"contacts":51},"London","E1 1BB",{"type":76,"coordinates":596},[597,598],-0.12574,51.50853,{"lat":598,"lon":597},{"facility":68,"status":69,"city":601,"state":51,"zip":602,"country":569,"countryCode":570,"cosmosGeoPoint":603,"geoPoint":607,"contacts":51},"Norwich","NR4 7UY",{"type":76,"coordinates":604},[605,606],1.29834,52.62783,{"lat":606,"lon":605},{"type":609,"investigatorFullName":51,"investigatorTitle":51,"investigatorAffiliation":51,"oldNameTitle":51,"oldOrganization":51},"SPONSOR",[611],{"name":612,"class":6},"Parexel","100598301","phase-2-a-study-of-novel-agents-or-combinations-as-perioperative-treatment-in-participants-with-locally-advanced-resectable-gastroesophageal-adenocarcinoma-100598301",false,"NCT07069712","A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma","A Master Protocol of an Open-Label, Multi-Drug, Multi-Center, Phase II Platform Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma (GEMINI-PeriOp GC)","Inclusion Criteria:\n\n* Histologically documented gastric, GEJ, or esophageal adenocarcinoma with resectable disease\n* Participants who are CLDN18.2-positive and HER2-negative in Sub-study 1 or HER2-positive in Sub-study 2; no specific requirements for Sub-study 3\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1\n* Adequate organ and bone marrow function\n* Body weight \\> 35 kg\n\nExclusion Criteria:\n\n* Participants had any prior anti-cancer treatment or surgery for the current gastric, GEJ, or esophageal cancer.\n* Active or prior documented autoimmune or inflammatory disorders requiring systemic treatment with steroids or other immunosuppressive treatment\n* Central nervous system (CNS) pathology\n* Uncontrolled infections\n* Participants with history of (non-infectious) interstitial lung disease (ILD)\u002Fpneumonitis, current ILD\u002Fpneumonitis, or suspected ILD\u002Fpneumonitis\n* History of another primary malignancy\n* Participants with any known or suspicious distant metastasis\n* Uncontrolled hepatitis B and\u002For chronic or active hepatitis B\n* Current or prior use of immunosuppressive medication within 14 days before the first dose of study intervention","ALL","18 Years",{"count":623,"type":624},100,"ESTIMATED","INTERVENTIONAL",[627],"PHASE2","GEMINI-PeriOp GC study will assess the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of novel agents or novel combinations as perioperative treatment in participants with locally advanced resectable gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma who have not received previous treatment for the disease.",[630],"Gastroesophageal Adenocarcinoma",[632,633,634,635,636,637,638],"Locally Advanced Resectable Gastroesophageal Adenocarcinoma","Gastroesophageal Junction","Neoadjuvant Treatment","Perioperative Treatment","Gastric cancer","Immune checkpoint inhibitors","Chemotherapy","2026-06-12",{"date":641,"type":642},"2026-06-15","ACTUAL",{"date":644,"type":642},"2025-07-17",{"date":646,"type":624},"2028-09-06",{"name":5,"class":6},70]