[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642828":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":487,"collaborators":30,"id":489,"slug":490,"hasResults":491,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":491,"sex":497,"minAge":498,"maxAge":30,"enrollmentInfo":499,"targetDuration":30,"studyType":502,"phases":503,"briefSummary":505,"conditions":506,"keywords":515,"overallStatus":144,"whyStopped":30,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":528},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1","EXPERIMENTAL","Participants receive subcutaneous injections of PF-08653945 or placebo.",[13,14],"Drug: PF-08653945","Drug: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Cohort 2","Participants receive subcutaneous injections of PF-08653945 + PF-08653944 or placebo.",[13,19,14],"Drug: PF-08653944",{"label":21,"type":10,"description":22,"interventionNames":23},"Cohort 3","Participants receive subcutaneous injections of PF-08653945 + PF-08653944 , PF-08653944 , or placebo.",[13,19,14],[25,31,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","PF-08653945","Subcutaneous Injection",[9,16,21],null,{"type":26,"name":32,"description":28,"armGroupLabels":33,"otherNames":30},"PF-08653944",[16,21],{"type":26,"name":35,"description":28,"armGroupLabels":36,"otherNames":30},"Placebo",[9,16,21],[38],{"name":39,"affiliation":5,"role":40},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":30,"email":45},"CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[47,61,70,79,89,98,106,115,124,133,142,152,162,171,180,189,199,208,219,228,238,248,256,266,275,285,295,301,311,320,329,338,348,358,366,376,385,395,404,413,422,431,440,445,454,464,469,479],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":30},"Arizona Clinical Trials-Chandler","NOT_YET_RECRUITING","Chandler","Arizona","85225","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-111.84125,33.30616,{"lat":59,"lon":58},{"facility":62,"status":49,"city":63,"state":51,"zip":64,"country":53,"countryCode":54,"cosmosGeoPoint":65,"geoPoint":69,"contacts":30},"Clinical Research Institute of Arizona","Sun City West","85375",{"type":56,"coordinates":66},[67,68],-112.34127,33.66198,{"lat":68,"lon":67},{"facility":71,"status":49,"city":72,"state":51,"zip":73,"country":53,"countryCode":54,"cosmosGeoPoint":74,"geoPoint":78,"contacts":30},"Arizona Clinical Trials (ACT) - Tucson","Tucson","85711",{"type":56,"coordinates":75},[76,77],-110.92648,32.22174,{"lat":77,"lon":76},{"facility":80,"status":49,"city":81,"state":82,"zip":83,"country":53,"countryCode":54,"cosmosGeoPoint":84,"geoPoint":88,"contacts":30},"Ark Clinical Research","Fountain Valley","California","92708",{"type":56,"coordinates":85},[86,87],-117.95367,33.70918,{"lat":87,"lon":86},{"facility":90,"status":49,"city":91,"state":82,"zip":92,"country":53,"countryCode":54,"cosmosGeoPoint":93,"geoPoint":97,"contacts":30},"Paragon Rx Clinical","Garden Grove","92840",{"type":56,"coordinates":94},[95,96],-117.94145,33.77391,{"lat":96,"lon":95},{"facility":80,"status":49,"city":99,"state":82,"zip":100,"country":53,"countryCode":54,"cosmosGeoPoint":101,"geoPoint":105,"contacts":30},"Long Beach","90815",{"type":56,"coordinates":102},[103,104],-118.18923,33.76696,{"lat":104,"lon":103},{"facility":107,"status":49,"city":108,"state":82,"zip":109,"country":53,"countryCode":54,"cosmosGeoPoint":110,"geoPoint":114,"contacts":30},"Collaborative Neuroscience Research, LLC","Los Alamitos","90720",{"type":56,"coordinates":111},[112,113],-118.07256,33.80307,{"lat":113,"lon":112},{"facility":116,"status":49,"city":117,"state":82,"zip":118,"country":53,"countryCode":54,"cosmosGeoPoint":119,"geoPoint":123,"contacts":30},"Paradigm Clinical Research-Modesto","Modesto","95355",{"type":56,"coordinates":120},[121,122],-120.99688,37.6391,{"lat":122,"lon":121},{"facility":125,"status":49,"city":126,"state":82,"zip":127,"country":53,"countryCode":54,"cosmosGeoPoint":128,"geoPoint":132,"contacts":30},"Paradigm Clinical Research Centers, LLC","San Diego","92108",{"type":56,"coordinates":129},[130,131],-117.16472,32.71571,{"lat":131,"lon":130},{"facility":134,"status":49,"city":135,"state":82,"zip":136,"country":53,"countryCode":54,"cosmosGeoPoint":137,"geoPoint":141,"contacts":30},"University Clinical Investigators, Incorporated","Tustin","92780",{"type":56,"coordinates":138},[139,140],-117.82617,33.74585,{"lat":140,"lon":139},{"facility":143,"status":144,"city":145,"state":82,"zip":146,"country":53,"countryCode":54,"cosmosGeoPoint":147,"geoPoint":151,"contacts":30},"Diablo Clinical Research, LLC dba Flourish Research","RECRUITING","Walnut Creek","94598",{"type":56,"coordinates":148},[149,150],-122.06496,37.90631,{"lat":150,"lon":149},{"facility":153,"status":49,"city":154,"state":155,"zip":156,"country":53,"countryCode":54,"cosmosGeoPoint":157,"geoPoint":161,"contacts":30},"AGA Clinical Trials","Hialeah","Florida","33012",{"type":56,"coordinates":158},[159,160],-80.27811,25.8576,{"lat":160,"lon":159},{"facility":163,"status":49,"city":164,"state":155,"zip":165,"country":53,"countryCode":54,"cosmosGeoPoint":166,"geoPoint":170,"contacts":30},"Westside Center for Clinical Research","Jacksonville","32205",{"type":56,"coordinates":167},[168,169],-81.65565,30.33218,{"lat":169,"lon":168},{"facility":172,"status":49,"city":173,"state":155,"zip":174,"country":53,"countryCode":54,"cosmosGeoPoint":175,"geoPoint":179,"contacts":30},"New Horizon Research Center","Miami","33165",{"type":56,"coordinates":176},[177,178],-80.19366,25.77427,{"lat":178,"lon":177},{"facility":181,"status":49,"city":182,"state":155,"zip":183,"country":53,"countryCode":54,"cosmosGeoPoint":184,"geoPoint":188,"contacts":30},"Charter Research","Orlando","32803",{"type":56,"coordinates":185},[186,187],-81.37924,28.53834,{"lat":187,"lon":186},{"facility":190,"status":49,"city":191,"state":192,"zip":193,"country":53,"countryCode":54,"cosmosGeoPoint":194,"geoPoint":198,"contacts":30},"Atlanta Diabetes Associates","Atlanta","Georgia","30318",{"type":56,"coordinates":195},[196,197],-84.38798,33.749,{"lat":197,"lon":196},{"facility":200,"status":49,"city":201,"state":192,"zip":202,"country":53,"countryCode":54,"cosmosGeoPoint":203,"geoPoint":207,"contacts":30},"Clinical Research Atlanta","Stockbridge","30281",{"type":56,"coordinates":204},[205,206],-84.23381,33.54428,{"lat":206,"lon":205},{"facility":209,"status":210,"city":211,"state":212,"zip":213,"country":53,"countryCode":54,"cosmosGeoPoint":214,"geoPoint":218,"contacts":30},"Koch Family Medicine Clinical Research\u002FElite Research Network","ACTIVE_NOT_RECRUITING","Morton","Illinois","61550",{"type":56,"coordinates":215},[216,217],-89.45926,40.61282,{"lat":217,"lon":216},{"facility":220,"status":49,"city":221,"state":212,"zip":222,"country":53,"countryCode":54,"cosmosGeoPoint":223,"geoPoint":227,"contacts":30},"Bioluminux Clinical Research Illinois","Naperville","60540",{"type":56,"coordinates":224},[225,226],-88.14729,41.78586,{"lat":226,"lon":225},{"facility":229,"status":49,"city":230,"state":231,"zip":232,"country":53,"countryCode":54,"cosmosGeoPoint":233,"geoPoint":237,"contacts":30},"Johnson County Clinical Trials","Lenexa","Kansas","66219",{"type":56,"coordinates":234},[235,236],-94.73357,38.95362,{"lat":236,"lon":235},{"facility":239,"status":210,"city":240,"state":241,"zip":242,"country":53,"countryCode":54,"cosmosGeoPoint":243,"geoPoint":247,"contacts":30},"DelRicht Research","Mandeville","Louisiana","70471",{"type":56,"coordinates":244},[245,246],-90.06563,30.35825,{"lat":246,"lon":245},{"facility":239,"status":210,"city":249,"state":241,"zip":250,"country":53,"countryCode":54,"cosmosGeoPoint":251,"geoPoint":255,"contacts":30},"Prairieville","70769",{"type":56,"coordinates":252},[253,254],-90.97205,30.30297,{"lat":254,"lon":253},{"facility":257,"status":49,"city":258,"state":259,"zip":260,"country":53,"countryCode":54,"cosmosGeoPoint":261,"geoPoint":265,"contacts":30},"Patient First Clinical Trials (PFCTRIALS)","Lutherville","Maryland","21093",{"type":56,"coordinates":262},[263,264],-76.62608,39.42122,{"lat":264,"lon":263},{"facility":239,"status":210,"city":267,"state":268,"zip":269,"country":53,"countryCode":54,"cosmosGeoPoint":270,"geoPoint":274,"contacts":30},"Springfield","Missouri","65807",{"type":56,"coordinates":271},[272,273],-93.29824,37.21533,{"lat":273,"lon":272},{"facility":276,"status":144,"city":277,"state":278,"zip":279,"country":53,"countryCode":54,"cosmosGeoPoint":280,"geoPoint":284,"contacts":30},"Mercury Street Medical Group, PLLC","Butte","Montana","59701",{"type":56,"coordinates":281},[282,283],-112.53474,46.00382,{"lat":283,"lon":282},{"facility":286,"status":49,"city":287,"state":288,"zip":289,"country":53,"countryCode":54,"cosmosGeoPoint":290,"geoPoint":294,"contacts":30},"Alliance Clinical Research Las Vegas (Excel Clinical Research)","Las Vegas","Nevada","89109",{"type":56,"coordinates":291},[292,293],-115.13722,36.17497,{"lat":293,"lon":292},{"facility":296,"status":144,"city":287,"state":288,"zip":297,"country":53,"countryCode":54,"cosmosGeoPoint":298,"geoPoint":300,"contacts":30},"AB Clinical Trials","89119",{"type":56,"coordinates":299},[292,293],{"lat":293,"lon":292},{"facility":302,"status":49,"city":303,"state":304,"zip":305,"country":53,"countryCode":54,"cosmosGeoPoint":306,"geoPoint":310,"contacts":30},"Bioluminux Clinical Research","Hamilton","New Jersey","08690",{"type":56,"coordinates":307},[308,309],-74.08125,40.20706,{"lat":309,"lon":308},{"facility":239,"status":144,"city":312,"state":313,"zip":314,"country":53,"countryCode":54,"cosmosGeoPoint":315,"geoPoint":319,"contacts":30},"Charlotte","North Carolina","28210",{"type":56,"coordinates":316},[317,318],-80.84313,35.22709,{"lat":318,"lon":317},{"facility":321,"status":144,"city":322,"state":313,"zip":323,"country":53,"countryCode":54,"cosmosGeoPoint":324,"geoPoint":328,"contacts":30},"Monroe Biomedical Research","Monroe","28112",{"type":56,"coordinates":325},[326,327],-80.54951,34.98543,{"lat":327,"lon":326},{"facility":330,"status":144,"city":331,"state":313,"zip":332,"country":53,"countryCode":54,"cosmosGeoPoint":333,"geoPoint":337,"contacts":30},"Piedmont Healthcare","Statesville","28625",{"type":56,"coordinates":334},[335,336],-80.8873,35.78264,{"lat":336,"lon":335},{"facility":339,"status":210,"city":340,"state":341,"zip":342,"country":53,"countryCode":54,"cosmosGeoPoint":343,"geoPoint":347,"contacts":30},"Tekton Research, LLC.","Edmond","Oklahoma","73013",{"type":56,"coordinates":344},[345,346],-97.4781,35.65283,{"lat":346,"lon":345},{"facility":349,"status":49,"city":350,"state":351,"zip":352,"country":53,"countryCode":54,"cosmosGeoPoint":353,"geoPoint":357,"contacts":30},"Preferred Primary Care Physicians","Pittsburgh","Pennsylvania","15236",{"type":56,"coordinates":354},[355,356],-79.99589,40.44062,{"lat":356,"lon":355},{"facility":349,"status":49,"city":359,"state":351,"zip":360,"country":53,"countryCode":54,"cosmosGeoPoint":361,"geoPoint":365,"contacts":30},"Uniontown","15401",{"type":56,"coordinates":362},[363,364],-79.71643,39.90008,{"lat":364,"lon":363},{"facility":367,"status":49,"city":368,"state":369,"zip":370,"country":53,"countryCode":54,"cosmosGeoPoint":371,"geoPoint":375,"contacts":30},"TMA Headlands LLC (d\u002Fb\u002Fa Trial Management Associates)","Myrtle Beach","South Carolina","29572",{"type":56,"coordinates":372},[373,374],-78.88669,33.68906,{"lat":374,"lon":373},{"facility":239,"status":144,"city":377,"state":378,"zip":379,"country":53,"countryCode":54,"cosmosGeoPoint":380,"geoPoint":384,"contacts":30},"Hendersonville","Tennessee","37075",{"type":56,"coordinates":381},[382,383],-86.62,36.30477,{"lat":383,"lon":382},{"facility":386,"status":49,"city":387,"state":388,"zip":389,"country":53,"countryCode":54,"cosmosGeoPoint":390,"geoPoint":394,"contacts":30},"Cedar Health Research - Euless","Euless","Texas","76040",{"type":56,"coordinates":391},[392,393],-97.08195,32.83707,{"lat":393,"lon":392},{"facility":396,"status":144,"city":397,"state":388,"zip":398,"country":53,"countryCode":54,"cosmosGeoPoint":399,"geoPoint":403,"contacts":30},"JCCT-JUNO NW Houston","Houston","77040",{"type":56,"coordinates":400},[401,402],-95.36327,29.76328,{"lat":402,"lon":401},{"facility":405,"status":49,"city":406,"state":388,"zip":407,"country":53,"countryCode":54,"cosmosGeoPoint":408,"geoPoint":412,"contacts":30},"Activian Clinical Research","Kingwood","77339",{"type":56,"coordinates":409},[410,411],-95.18349,30.05691,{"lat":411,"lon":410},{"facility":414,"status":49,"city":415,"state":388,"zip":416,"country":53,"countryCode":54,"cosmosGeoPoint":417,"geoPoint":421,"contacts":30},"3A Research","Plano","75093",{"type":56,"coordinates":418},[419,420],-96.69889,33.01984,{"lat":420,"lon":419},{"facility":423,"status":210,"city":424,"state":388,"zip":425,"country":53,"countryCode":54,"cosmosGeoPoint":426,"geoPoint":430,"contacts":30},"DelRicht Research @ Zomnir Family Medicine","Prosper","75078",{"type":56,"coordinates":427},[428,429],-96.80111,33.23623,{"lat":429,"lon":428},{"facility":432,"status":49,"city":433,"state":388,"zip":434,"country":53,"countryCode":54,"cosmosGeoPoint":435,"geoPoint":439,"contacts":30},"Worldwide Clinical Trials","San Antonio","78217",{"type":56,"coordinates":436},[437,438],-98.49363,29.42412,{"lat":438,"lon":437},{"facility":339,"status":210,"city":433,"state":388,"zip":441,"country":53,"countryCode":54,"cosmosGeoPoint":442,"geoPoint":444,"contacts":30},"78258",{"type":56,"coordinates":443},[437,438],{"lat":438,"lon":437},{"facility":446,"status":144,"city":447,"state":388,"zip":448,"country":53,"countryCode":54,"cosmosGeoPoint":449,"geoPoint":453,"contacts":30},"DM Clinical Research","Tomball","77375",{"type":56,"coordinates":450},[451,452],-95.61605,30.09716,{"lat":452,"lon":451},{"facility":455,"status":49,"city":456,"state":457,"zip":458,"country":53,"countryCode":54,"cosmosGeoPoint":459,"geoPoint":463,"contacts":30},"Alpine Medical Group","Salt Lake City","Utah","84107",{"type":56,"coordinates":460},[461,462],-111.89105,40.76078,{"lat":462,"lon":461},{"facility":465,"status":49,"city":456,"state":457,"zip":458,"country":53,"countryCode":54,"cosmosGeoPoint":466,"geoPoint":468,"contacts":30},"Wasatch Clinical Research, LLC",{"type":56,"coordinates":467},[461,462],{"lat":462,"lon":461},{"facility":470,"status":49,"city":471,"state":472,"zip":473,"country":53,"countryCode":54,"cosmosGeoPoint":474,"geoPoint":478,"contacts":30},"Manassas Clinical Research Center","Manassas","Virginia","20110",{"type":56,"coordinates":475},[476,477],-77.47527,38.75095,{"lat":477,"lon":476},{"facility":239,"status":49,"city":480,"state":472,"zip":481,"country":53,"countryCode":54,"cosmosGeoPoint":482,"geoPoint":486,"contacts":30},"Vienna","22182",{"type":56,"coordinates":483},[484,485],-77.26526,38.90122,{"lat":485,"lon":484},{"type":488,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100642828","phase-2-a-study-of-pf-08653945-and-pf-08653944-in-adults-with-overweight-or-obesity-solis-1-100642828",false,"NCT07575932","A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)","A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)","SOLIS-1","Inclusion Criteria:\n\nEligible participants for this study include:\n\n* adults aged 18 years or older with\n* obesity (BMI of 30.0 kg\u002Fm2 to 50.0 kg\u002Fm2) or with\n* overweight (BMI of 27.0 kg\u002Fm2 to \\\u003C30.0 kg\u002Fm2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.\n\nExclusion Criteria:\n\nParticipants who are not eligible include those with diabetes mellitus, a body weight change of \\>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.","ALL","18 Years",{"count":500,"type":501},872,"ESTIMATED","INTERVENTIONAL",[504],"PHASE2","This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).",[507,508,509,510,511,512,513,514],"Overweight","Obesity","Overweight and\u002For Obesity","Overweight or Obesity","Overnutrition","Nutrition Disorders","Nutritional and Metabolic Diseases","Body Weight",[511,512,513,514,508,507,516,517,518],"GLP-1RA","Amylin","DACRA","2026-06-09",{"date":521,"type":522},"2026-06-10","ACTUAL",{"date":524,"type":522},"2026-05-11",{"date":526,"type":501},"2028-01-05",{"name":5,"class":6},48]