[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100491192":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":164,"collaborators":42,"id":166,"slug":167,"hasResults":168,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":42,"eligibilityCriteria":172,"healthyVolunteers":168,"sex":173,"minAge":174,"maxAge":42,"enrollmentInfo":175,"targetDuration":42,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":186,"overallStatus":51,"whyStopped":42,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult and pediatric patients who received an allogeneic stem cell transplant (allo-HCT)","ACTIVE_COMPARATOR","Participants are Allo-HCT recipients",[13],"Device: Photobiomodulation Therapy",{"label":15,"type":16,"description":11,"interventionNames":17},"Adult and pediatric patients who received a placebo treatment","PLACEBO_COMPARATOR",[18],"Other: Placebo sham device",[20,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Photobiomodulation Therapy","Participants with a history of allo-HCT and diagnosis with oral chronic GvHD randomized to the treatment arm will be treated with oral photobiomodulation\u002FPBM (via Thor LX2.3 system device) for 28 days",[9],[26,27],"PBM Therapy","Thor LX2.3 system device",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo sham device","Participants with a history of allo-HCT and diagnosis with oral chronic GvHD randomized to the placebo arm will be treated with a placebo sham device (via Thor LX2.3 sham device setting) for 28 days",[15],[33],"Thor LX2.3 sham device setting",[35],{"name":36,"affiliation":5,"role":37},"Alina Markova, MD","PRINCIPAL_INVESTIGATOR",[39,44],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","6466082342",null,"markovaa@mskcc.org",{"name":45,"role":40,"phone":46,"phoneExt":42,"email":47},"Doris Ponce, MD","646-608-3739","ponced@mskcc.org",[49,68,81,92,104,116,127,137,149],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"National Institute of Health (Data Collection AND Specimen Analysis)","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-77.10026,38.98067,{"lat":61,"lon":60},[64],{"name":65,"role":40,"phone":66,"phoneExt":42,"email":67},"Jacqueline Mays, DDS, MHSc, PhD","(301) 496-8800","jacqueline.mays@nih.gov",{"facility":69,"status":51,"city":70,"state":71,"zip":72,"country":55,"countryCode":56,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Memorial Sloan Kettering at Basking Ridge (Consent only)","Basking Ridge","New Jersey","07920",{"type":58,"coordinates":74},[75,76],-74.54932,40.70621,{"lat":76,"lon":75},[79],{"name":36,"role":40,"phone":80,"phoneExt":42,"email":42},"646-608-2342",{"facility":82,"status":51,"city":83,"state":71,"zip":84,"country":55,"countryCode":56,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Memorial Sloan Kettering Monmouth (Consent only)","Middletown","07748",{"type":58,"coordinates":86},[87,88],-74.11709,40.39428,{"lat":88,"lon":87},[91],{"name":36,"role":40,"phone":80,"phoneExt":42,"email":42},{"facility":93,"status":51,"city":94,"state":71,"zip":95,"country":55,"countryCode":56,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Memorial Sloan Kettering Cancer Center @ Bergen (Consent only)","Montvale","07645",{"type":58,"coordinates":97},[98,99],-74.02292,41.04676,{"lat":99,"lon":98},[102],{"name":103,"role":40,"phone":80,"phoneExt":42,"email":42},"Alina K Markova, MD",{"facility":105,"status":51,"city":106,"state":107,"zip":108,"country":55,"countryCode":56,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Memorial Sloan Kettering Cancer Center @ Commack (Consent only)","Commack","New York","11725",{"type":58,"coordinates":110},[111,112],-73.29289,40.84288,{"lat":112,"lon":111},[115],{"name":103,"role":40,"phone":80,"phoneExt":42,"email":42},{"facility":117,"status":51,"city":118,"state":107,"zip":119,"country":55,"countryCode":56,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Memorial Sloan Kettering Westchester (Consent only)","Harrison","10604",{"type":58,"coordinates":121},[122,123],-73.71263,40.96899,{"lat":123,"lon":122},[126],{"name":36,"role":40,"phone":80,"phoneExt":42,"email":42},{"facility":128,"status":51,"city":107,"state":107,"zip":129,"country":55,"countryCode":56,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","10065",{"type":58,"coordinates":131},[132,133],-74.00597,40.71427,{"lat":133,"lon":132},[136],{"name":36,"role":40,"phone":80,"phoneExt":42,"email":42},{"facility":138,"status":51,"city":139,"state":107,"zip":140,"country":55,"countryCode":56,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Memorial Sloan Kettering Cancer Center @ Nassau (Consent only)","Uniondale","11553",{"type":58,"coordinates":142},[143,144],-73.59291,40.70038,{"lat":144,"lon":143},[147],{"name":148,"role":40,"phone":80,"phoneExt":42,"email":42},"Alina K Markova, MD, PhD",{"facility":150,"status":51,"city":151,"state":152,"zip":153,"country":55,"countryCode":56,"cosmosGeoPoint":154,"geoPoint":158,"contacts":159},"University of Pittsburgh Medical Center (Data Collection Only)","Pittsburgh","Pennsylvania","15213",{"type":58,"coordinates":155},[156,157],-79.99589,40.44062,{"lat":157,"lon":156},[160],{"name":161,"role":40,"phone":162,"phoneExt":42,"email":163},"Annie Im, MD","412-864-7764","imap@upmc.edu",{"type":165,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100491192","phase-2-a-study-of-photobiomodulation-pbm-therapy-in-people-with-oral-graft-versus-host-disease-gvhd-after-stem-cell-transplant-100491192",false,"NCT05675930","A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant","A Multi-Center, Phase II, Randomized Double-Blind Trial to Evaluate the Efficacy and Safety of Photobiomodulation for the Treatment of Oral Chronic Graft-Versus-Host Disease After Allogeneic Stem Cell Transplantation (the LIGHT Trial)","Inclusion Criteria:\n\n* Allo-HCT recipients\n* Age ≥ 4 years-old\n* Oral cGvHD with NIH-modified OMRS score ≥ 3 who have failed ≥ 1 line of therapy, including topical corticosteroids..\n* No change in systemic immunosuppressive therapy (type or intensity level) within 2 weeks prior to enrollment.\n* If a patient is currently using another oral topical treatment for mouth lesions\u002Fsymptoms, patient must be stable on this treatment for ≥2 weeks prior to study enrollment. Patient may continue same topical dose\u002Ffrequency during the study period.\n\nExclusion Criteria:\n\n* Presence of an active uncontrolled infection. Subjects with a controlled infection receiving definitive therapy for 48 hours prior to enrollment are eligible.\n* Personal history of mucosal head and neck cancer in the past 5 years.\n* Pregnant or breastfeeding.\n* The subject or guardian is unable to give informed consent or unable to comply with the treatment protocol including appropriate supportive care, follow-up, and research tests.\n* Any serious medical or psychiatric illness that could, in the Investigator's opinion, potentially interfere with the completion of treatment according to this protocol.","ALL","4 Years",{"count":176,"type":177},44,"ESTIMATED","INTERVENTIONAL",[180],"PHASE2","The purpose of this study is to find out whether photobiomodulation\u002FPBM therapy using the Thor LX2.3 therapy system is a safe and effective treatment for oral Graft-Versus-Host Disease\u002FGVHD.",[183,184,185],"Graft-Versus-Host Disease","GVHD","Undefined",[183,184,187,188,5,189],"Chronic Graft Versus Host Disease Oral","PhotobiomoduLatIon","22-271","2026-05-20",{"date":192,"type":193},"2026-05-22","ACTUAL",{"date":195,"type":193},"2022-12-22",{"date":197,"type":177},"2026-12-22",{"name":5,"class":6},9]